AU5150093A - Pure enantiomers of phosphoric-acid esters as phospholipase-a2 inhibitors - Google Patents

Pure enantiomers of phosphoric-acid esters as phospholipase-a2 inhibitors

Info

Publication number
AU5150093A
AU5150093A AU51500/93A AU5150093A AU5150093A AU 5150093 A AU5150093 A AU 5150093A AU 51500/93 A AU51500/93 A AU 51500/93A AU 5150093 A AU5150093 A AU 5150093A AU 5150093 A AU5150093 A AU 5150093A
Authority
AU
Australia
Prior art keywords
phospholipase
inhibitors
phosphoric
acid esters
pure enantiomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU51500/93A
Other languages
English (en)
Inventor
Hansjorg Eibl
Ulrich Massing
Clemens Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of AU5150093A publication Critical patent/AU5150093A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU51500/93A 1992-10-09 1993-10-08 Pure enantiomers of phosphoric-acid esters as phospholipase-a2 inhibitors Abandoned AU5150093A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4234130A DE4234130A1 (de) 1992-10-09 1992-10-09 Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen
DE4234130 1992-10-09
PCT/EP1993/002762 WO1994009014A1 (de) 1992-10-09 1993-10-08 Enantiomerenreine phosphorsaureestern als phospholipase a2-inhibitoren

Publications (1)

Publication Number Publication Date
AU5150093A true AU5150093A (en) 1994-05-09

Family

ID=6470117

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51500/93A Abandoned AU5150093A (en) 1992-10-09 1993-10-08 Pure enantiomers of phosphoric-acid esters as phospholipase-a2 inhibitors

Country Status (5)

Country Link
EP (1) EP0663918A1 (de)
JP (1) JPH08502735A (de)
AU (1) AU5150093A (de)
DE (1) DE4234130A1 (de)
WO (1) WO1994009014A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2065855B1 (es) * 1993-05-31 1995-09-01 Menarini Lab Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos.
WO2006024675A1 (de) * 2004-09-03 2006-03-09 Forschungszentrum Karlsruhe Gmbh Verwendung von alkylphospholipiden zur behandlung solider tumore
EP1745788A1 (de) 2005-07-22 2007-01-24 KTB Tumorforschungsgesellschaft mbH Acylglycerophospholipide zur Behandlung von Krebs und Tumorkachexie
JP2015120665A (ja) * 2013-12-24 2015-07-02 日油株式会社 アルキニル基含有ホスホリルコリン化合物及びその製造方法、並びにアジド基含有化合物修飾剤
EP3895709A1 (de) 2020-04-17 2021-10-20 Andreas Hettich GmbH & Co. KG Phospholipide und phospholipid-metaboliten zur behandlung von viralen und bakteriellen lungenentzündungen und sepsis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562179A (en) * 1982-04-19 1985-12-31 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, and pharmaceutical composition of the same
US4585762A (en) * 1982-07-30 1986-04-29 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same
US4640913A (en) * 1983-01-10 1987-02-03 American Cyanamid Company Phosphocholine derivatives having antihypertensive action
DE3304870A1 (de) * 1983-02-12 1984-08-16 Boehringer Mannheim Gmbh, 6800 Mannheim Neue phospholipide, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3307925A1 (de) * 1983-03-05 1984-09-06 A. Nattermann & Cie GmbH, 5000 Köln Neue 0-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4659859A (en) * 1984-07-02 1987-04-21 Eli Lilly And Company 2-alkoxy-1-alkoxy phosphoryl dichlorides
US5144045A (en) * 1990-11-13 1992-09-01 American Cyanamid Company Phosphocholine derivative inhibitors of phospholipase A2

Also Published As

Publication number Publication date
WO1994009014A1 (de) 1994-04-28
DE4234130A1 (de) 1994-04-14
EP0663918A1 (de) 1995-07-26
JPH08502735A (ja) 1996-03-26

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