AU499472B2 - Spiro ( cyclopropane-1, 2- indolin)-3 ones - Google Patents

Spiro ( cyclopropane-1, 2- indolin)-3 ones

Info

Publication number
AU499472B2
AU499472B2 AU19974/76A AU1997476A AU499472B2 AU 499472 B2 AU499472 B2 AU 499472B2 AU 19974/76 A AU19974/76 A AU 19974/76A AU 1997476 A AU1997476 A AU 1997476A AU 499472 B2 AU499472 B2 AU 499472B2
Authority
AU
Australia
Prior art keywords
spiro
compound
indolin
namely
cyclopropane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU19974/76A
Other languages
English (en)
Other versions
AU1997476A (en
Inventor
S. Takei S. & Kawano Y Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of AU1997476A publication Critical patent/AU1997476A/en
Application granted granted Critical
Publication of AU499472B2 publication Critical patent/AU499472B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU19974/76A 1975-11-26 1976-11-24 Spiro ( cyclopropane-1, 2- indolin)-3 ones Expired AU499472B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP141748/7 1975-11-26
JP50141748A JPS5265267A (en) 1975-11-26 1975-11-26 Synthesis of spiro compounds

Publications (2)

Publication Number Publication Date
AU1997476A AU1997476A (en) 1978-06-01
AU499472B2 true AU499472B2 (en) 1979-04-26

Family

ID=15299270

Family Applications (1)

Application Number Title Priority Date Filing Date
AU19974/76A Expired AU499472B2 (en) 1975-11-26 1976-11-24 Spiro ( cyclopropane-1, 2- indolin)-3 ones

Country Status (12)

Country Link
US (1) US4105670A (enExample)
JP (1) JPS5265267A (enExample)
AU (1) AU499472B2 (enExample)
BE (1) BE848766A (enExample)
CA (1) CA1091656A (enExample)
CH (1) CH623811A5 (enExample)
DE (1) DE2653477A1 (enExample)
DK (1) DK526476A (enExample)
FR (1) FR2362125A1 (enExample)
GB (1) GB1570596A (enExample)
NL (1) NL7613187A (enExample)
SE (1) SE421692B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284644A (en) * 1977-01-12 1981-08-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
US4342779A (en) * 1977-12-27 1982-08-03 Takeda Chemical Industries, Ltd. 7-Acetylspirobenzofuranone compound
JPS5646879A (en) * 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder
US4330554A (en) * 1980-04-23 1982-05-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
FR2501676A1 (fr) * 1981-03-11 1982-09-17 Rhone Poulenc Spec Chim Procede de n-alkylation de composes organiques azotes
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors

Also Published As

Publication number Publication date
GB1570596A (en) 1980-07-02
BE848766A (fr) 1977-05-25
SE7613218L (sv) 1977-05-27
FR2362125A1 (fr) 1978-03-17
AU1997476A (en) 1978-06-01
DE2653477A1 (de) 1977-06-08
US4105670A (en) 1978-08-08
CH623811A5 (enExample) 1981-06-30
SE421692B (sv) 1982-01-25
CA1091656A (en) 1980-12-16
JPS5265267A (en) 1977-05-30
NL7613187A (nl) 1977-05-31
DK526476A (da) 1977-05-27
FR2362125B1 (enExample) 1982-07-09

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