JPS5265267A - Synthesis of spiro compounds - Google Patents

Synthesis of spiro compounds

Info

Publication number
JPS5265267A
JPS5265267A JP50141748A JP14174875A JPS5265267A JP S5265267 A JPS5265267 A JP S5265267A JP 50141748 A JP50141748 A JP 50141748A JP 14174875 A JP14174875 A JP 14174875A JP S5265267 A JPS5265267 A JP S5265267A
Authority
JP
Japan
Prior art keywords
synthesis
spiro compounds
spiro
substituent groups
indolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP50141748A
Other languages
English (en)
Inventor
Shunsaku Noguchi
Saburo Takei
Yasuhiko Kawano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP50141748A priority Critical patent/JPS5265267A/ja
Priority to US05/743,404 priority patent/US4105670A/en
Priority to DK526476A priority patent/DK526476A/da
Priority to AU19974/76A priority patent/AU499472B2/en
Priority to BE172720A priority patent/BE848766A/xx
Priority to NL7613187A priority patent/NL7613187A/xx
Priority to GB49179/76A priority patent/GB1570596A/en
Priority to DE19762653477 priority patent/DE2653477A1/de
Priority to CA266,565A priority patent/CA1091656A/en
Priority to SE7613218A priority patent/SE421692B/xx
Priority to FR7635469A priority patent/FR2362125A1/fr
Priority to CH1494276A priority patent/CH623811A5/de
Publication of JPS5265267A publication Critical patent/JPS5265267A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP50141748A 1975-11-26 1975-11-26 Synthesis of spiro compounds Pending JPS5265267A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP50141748A JPS5265267A (en) 1975-11-26 1975-11-26 Synthesis of spiro compounds
US05/743,404 US4105670A (en) 1975-11-26 1976-11-19 Spiro[cyclopropane-1,2'-indolin]-3'-ones
DK526476A DK526476A (da) 1975-11-26 1976-11-23 Fremgangsmade til fremstilling af apiro(cyklopropan-1,2i-indolin)-3i-oner
AU19974/76A AU499472B2 (en) 1975-11-26 1976-11-24 Spiro ( cyclopropane-1, 2- indolin)-3 ones
BE172720A BE848766A (fr) 1975-11-26 1976-11-25 Spiro (cyclopropane-1,2'-indolin)-3'-ones, leur preparation et leur utilisation
NL7613187A NL7613187A (nl) 1975-11-26 1976-11-25 Werkwijze ter bereiding van nieuwe spiroverbin- dingen, benevens werkwijze ter bereiding van farmaceutische preparaten.
GB49179/76A GB1570596A (en) 1975-11-26 1976-11-25 Spiro (cyclopropane-1,2'-indoline)-3'-ones
DE19762653477 DE2653477A1 (de) 1975-11-26 1976-11-25 Spiro eckige klammer auf cyclopropan- 1,2'-indolin eckige klammer zu -3'-one
CA266,565A CA1091656A (en) 1975-11-26 1976-11-25 Spiro¬cyclopropane-1,2'-indolin|-3'-ones
SE7613218A SE421692B (sv) 1975-11-26 1976-11-25 Analogiforfarande for framstellning av spiro(cyklopropan-1,2Ÿ-indolin)-3Ÿ-on-foreningar
FR7635469A FR2362125A1 (fr) 1975-11-26 1976-11-25 Spiro(cyclopropane-1,2'-indolin)-3'-ones
CH1494276A CH623811A5 (ja) 1975-11-26 1976-11-26

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50141748A JPS5265267A (en) 1975-11-26 1975-11-26 Synthesis of spiro compounds

Publications (1)

Publication Number Publication Date
JPS5265267A true JPS5265267A (en) 1977-05-30

Family

ID=15299270

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50141748A Pending JPS5265267A (en) 1975-11-26 1975-11-26 Synthesis of spiro compounds

Country Status (12)

Country Link
US (1) US4105670A (ja)
JP (1) JPS5265267A (ja)
AU (1) AU499472B2 (ja)
BE (1) BE848766A (ja)
CA (1) CA1091656A (ja)
CH (1) CH623811A5 (ja)
DE (1) DE2653477A1 (ja)
DK (1) DK526476A (ja)
FR (1) FR2362125A1 (ja)
GB (1) GB1570596A (ja)
NL (1) NL7613187A (ja)
SE (1) SE421692B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284644A (en) * 1977-01-12 1981-08-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
US4342779A (en) * 1977-12-27 1982-08-03 Takeda Chemical Industries, Ltd. 7-Acetylspirobenzofuranone compound
JPS5646879A (en) * 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder
US4330554A (en) * 1980-04-23 1982-05-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
FR2501676A1 (fr) * 1981-03-11 1982-09-17 Rhone Poulenc Spec Chim Procede de n-alkylation de composes organiques azotes
CA2589363A1 (en) * 2004-12-13 2006-06-22 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors

Also Published As

Publication number Publication date
SE421692B (sv) 1982-01-25
DE2653477A1 (de) 1977-06-08
NL7613187A (nl) 1977-05-31
BE848766A (fr) 1977-05-25
AU499472B2 (en) 1979-04-26
FR2362125A1 (fr) 1978-03-17
DK526476A (da) 1977-05-27
AU1997476A (en) 1978-06-01
CA1091656A (en) 1980-12-16
US4105670A (en) 1978-08-08
SE7613218L (sv) 1977-05-27
FR2362125B1 (ja) 1982-07-09
GB1570596A (en) 1980-07-02
CH623811A5 (ja) 1981-06-30

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