AU4665193A - A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein - Google Patents

A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein

Info

Publication number
AU4665193A
AU4665193A AU46651/93A AU4665193A AU4665193A AU 4665193 A AU4665193 A AU 4665193A AU 46651/93 A AU46651/93 A AU 46651/93A AU 4665193 A AU4665193 A AU 4665193A AU 4665193 A AU4665193 A AU 4665193A
Authority
AU
Australia
Prior art keywords
protein
recovering
solution containing
biologically active
active form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU46651/93A
Other languages
English (en)
Inventor
Eunkyu Lee
Doreen A Svihla
Ren-Der Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Veterinary Inc
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Publication of AU4665193A publication Critical patent/AU4665193A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU46651/93A 1992-07-02 1993-07-01 A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein Abandoned AU4665193A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90814692A 1992-07-02 1992-07-02
US908146 1992-07-02
PCT/US1993/006351 WO1994001453A1 (en) 1992-07-02 1993-07-01 A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein

Publications (1)

Publication Number Publication Date
AU4665193A true AU4665193A (en) 1994-01-31

Family

ID=25425274

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46651/93A Abandoned AU4665193A (en) 1992-07-02 1993-07-01 A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein

Country Status (7)

Country Link
EP (1) EP0650497A1 (xx)
CN (1) CN1039330C (xx)
AU (1) AU4665193A (xx)
PL (1) PL306858A1 (xx)
TW (1) TW235965B (xx)
WO (1) WO1994001453A1 (xx)
ZA (1) ZA934780B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
CN1269805A (zh) 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US7270809B2 (en) 1997-07-14 2007-09-18 Bolder Biotechnology, Inc. Cysteine variants of alpha interferon-2
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
AU739394B2 (en) * 1998-08-27 2001-10-11 Lg Chemical Limited Process for the preparation of active somatotropin from inclusion bodies
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
EP1284987B1 (en) 2000-05-16 2007-07-18 Bolder Biotechnology, Inc. Methods for refolding proteins containing free cysteine residues
EP2102355B1 (en) 2006-12-14 2016-03-02 Bolder Biotechnology, Inc. Long acting proteins and peptides and methods of making and using the same
US10633414B2 (en) * 2015-07-27 2020-04-28 Purdue Research Foundation Tandem folding methods to improve protein folding yield
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
CN111610324B (zh) * 2020-06-06 2022-10-14 北京均大检测科技有限公司 一种ripa裂解液及其制备方法
CN114878728A (zh) * 2022-05-06 2022-08-09 浙江大学 一种新型的抗体肽图检测还原方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
AU2257488A (en) * 1987-07-29 1989-03-01 Schering Biotech Corporation Purification of human interleukin-4 expressed in escherichia coli
JPH01132598A (ja) * 1987-10-14 1989-05-25 Pitman Moore Inc 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法
US5064943A (en) * 1988-12-16 1991-11-12 American Cyanamid Company Method for solubilization and naturation of somatotropin
DE69129747T2 (de) * 1990-09-05 1998-11-12 Southern Cross Biotech Pty. Ltd., Toorak, Victoria In lösung bringen von proteinen in aktiver form

Also Published As

Publication number Publication date
EP0650497A1 (en) 1995-05-03
TW235965B (xx) 1994-12-11
PL306858A1 (en) 1995-04-18
CN1083071A (zh) 1994-03-02
ZA934780B (en) 1994-03-17
CN1039330C (zh) 1998-07-29
WO1994001453A1 (en) 1994-01-20

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