AU4580301A - Cephalotaxine alkaloid compositions and uses thereof - Google Patents
Cephalotaxine alkaloid compositions and uses thereofInfo
- Publication number
- AU4580301A AU4580301A AU4580301A AU4580301A AU4580301A AU 4580301 A AU4580301 A AU 4580301A AU 4580301 A AU4580301 A AU 4580301A AU 4580301 A AU4580301 A AU 4580301A AU 4580301 A AU4580301 A AU 4580301A
- Authority
- AU
- Australia
- Prior art keywords
- cephalotaxine
- agents
- hydroxy
- host
- proliferative disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YMNCVRSYJBNGLD-KURKYZTESA-N cephalotaxine Chemical class C([C@@]12C=C([C@H]([C@H]2C2=C3)O)OC)CCN1CCC2=CC1=C3OCO1 YMNCVRSYJBNGLD-KURKYZTESA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 230000001028 anti-proliverative effect Effects 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 2
- DSRNKUZOWRFQFO-UHFFFAOYSA-N cephalotaxine Natural products COC1=CC23CCCN2CCc4cc5OCOc5cc4C3=C1O DSRNKUZOWRFQFO-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 101710172711 Structural protein Proteins 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 230000001086 cytosolic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000138 intercalating agent Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 abstract 1
- 229960002230 omacetaxine mepesuccinate Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000002212 purine nucleoside Substances 0.000 abstract 1
- 239000002718 pyrimidine nucleoside Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18969900P | 2000-03-15 | 2000-03-15 | |
| PCT/US2001/008480 WO2001068098A2 (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid combination compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU4580301A true AU4580301A (en) | 2001-09-24 |
Family
ID=22698410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU4580301A Pending AU4580301A (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid compositions and uses thereof |
| AU2001245803A Ceased AU2001245803B8 (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid compositions and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001245803A Ceased AU2001245803B8 (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid compositions and uses thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6734178B2 (https=) |
| EP (1) | EP1263440B1 (https=) |
| JP (1) | JP4929436B2 (https=) |
| AT (1) | ATE330611T1 (https=) |
| AU (2) | AU4580301A (https=) |
| CA (1) | CA2402710A1 (https=) |
| DE (1) | DE60120928T2 (https=) |
| DK (1) | DK1263440T3 (https=) |
| ES (1) | ES2267741T3 (https=) |
| PT (1) | PT1263440E (https=) |
| WO (1) | WO2001068098A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1263440T3 (da) * | 2000-03-15 | 2006-10-23 | Chemgenex Pharmaceuticals Inc | Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf |
| US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US7135481B2 (en) | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| WO2002056872A2 (en) * | 2000-10-31 | 2002-07-25 | Chemgenex Therapeutics, Inc. | Antiproliferative colchicine compositions and uses thereof |
| DE60313754T2 (de) * | 2002-03-06 | 2008-01-24 | The Medical Research and Education Trust, San Diego | Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin |
| US20040082565A1 (en) * | 2002-07-17 | 2004-04-29 | Chemgenex Therapeutics, Inc. | Formulations and methods of administration of cephalotaxines including homoharringtonine |
| US7642252B2 (en) | 2002-07-22 | 2010-01-05 | Chemgenex Pharmaceuticals, Inc. | Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof |
| CN100396286C (zh) * | 2002-12-30 | 2008-06-25 | 北京大学第一医院 | 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用 |
| WO2005117893A2 (en) * | 2004-06-04 | 2005-12-15 | Chemgenex Pharmaceuticals, Inc. | Methods of treating cellular proliferative disease using naphthalimide and parp-1 inhibitors |
| CA2597323A1 (en) * | 2005-02-10 | 2006-08-17 | Chemgenex Pharmaceuticals, Inc. | Medical devices |
| JP5550546B2 (ja) * | 2007-04-13 | 2014-07-16 | ケムジェネックス・ファーマシューティカルズ・インコーポレイテッド | 経口セファロタキシン剤形 |
| EP2260041A4 (en) | 2008-03-03 | 2012-04-25 | Sloan Kettering Inst Cancer | CEPHALOTAXUS ESTERS, METHOD FOR THEIR SYNTHESIS AND USES THEREOF |
| CN118217301B (zh) * | 2024-03-28 | 2025-08-05 | 宁波大学附属人民医院 | 一种协同治疗aml的含有8-氯腺苷和高三尖杉酯碱的药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4675318A (en) * | 1985-05-28 | 1987-06-23 | Yaguang Liu | Safe antileukemia drug, SAL |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| DK1263440T3 (da) * | 2000-03-15 | 2006-10-23 | Chemgenex Pharmaceuticals Inc | Cephalotaxinalkaloidkombinationspræparater og anvendelser deraf |
| EP1274458B1 (en) * | 2000-04-12 | 2005-09-28 | ChemGenex Pharmaceuticals, Inc. | Compositions containing a naphthalmide and an antiproliferative agent |
-
2001
- 2001-03-15 DK DK01918763T patent/DK1263440T3/da active
- 2001-03-15 AU AU4580301A patent/AU4580301A/xx active Pending
- 2001-03-15 CA CA002402710A patent/CA2402710A1/en not_active Abandoned
- 2001-03-15 AT AT01918763T patent/ATE330611T1/de active
- 2001-03-15 ES ES01918763T patent/ES2267741T3/es not_active Expired - Lifetime
- 2001-03-15 AU AU2001245803A patent/AU2001245803B8/en not_active Ceased
- 2001-03-15 US US09/810,527 patent/US6734178B2/en not_active Expired - Lifetime
- 2001-03-15 PT PT01918763T patent/PT1263440E/pt unknown
- 2001-03-15 WO PCT/US2001/008480 patent/WO2001068098A2/en not_active Ceased
- 2001-03-15 EP EP01918763A patent/EP1263440B1/en not_active Expired - Lifetime
- 2001-03-15 DE DE60120928T patent/DE60120928T2/de not_active Expired - Lifetime
- 2001-03-15 JP JP2001566662A patent/JP4929436B2/ja not_active Expired - Fee Related
-
2004
- 2004-01-30 US US10/769,638 patent/US20040185117A1/en not_active Abandoned
-
2010
- 2010-04-15 US US12/761,251 patent/US20110008307A1/en not_active Abandoned
-
2011
- 2011-12-23 US US13/336,917 patent/US20120207855A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2402710A1 (en) | 2001-09-20 |
| HK1052138A1 (en) | 2003-09-05 |
| US20040185117A1 (en) | 2004-09-23 |
| US20110008307A1 (en) | 2011-01-13 |
| DE60120928D1 (de) | 2006-08-03 |
| PT1263440E (pt) | 2006-11-30 |
| DE60120928T2 (de) | 2007-02-08 |
| JP4929436B2 (ja) | 2012-05-09 |
| DK1263440T3 (da) | 2006-10-23 |
| AU2001245803B8 (en) | 2006-02-02 |
| EP1263440A2 (en) | 2002-12-11 |
| JP2003526667A (ja) | 2003-09-09 |
| US6734178B2 (en) | 2004-05-11 |
| WO2001068098A2 (en) | 2001-09-20 |
| ES2267741T3 (es) | 2007-03-16 |
| US20120207855A1 (en) | 2012-08-16 |
| EP1263440B1 (en) | 2006-06-21 |
| US20020032190A1 (en) | 2002-03-14 |
| WO2001068098A3 (en) | 2002-06-06 |
| ATE330611T1 (de) | 2006-07-15 |
| AU2001245803B2 (en) | 2005-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU4580301A (en) | Cephalotaxine alkaloid compositions and uses thereof | |
| WO2000072799A3 (en) | Method and compositions for treating the inflammatory response | |
| AP2001002319A0 (en) | Pyrimidine-2,4,6-trione metalloproteinase inhibitors. | |
| AU5348301A (en) | Naphthalimide compositions and uses thereof | |
| CA2400554A1 (en) | Pyrimidine-4-one derivatives as ldl-pla2 inhibitors | |
| NO20020662D0 (no) | Pyrimidin-2,4,6-trion metalloproteinase inhibitorer | |
| HUP0303016A3 (en) | Xanthine phosphodiesterase v inhibitors, process for their preparation and pharmaceutical compositions containing them and their use | |
| HUP0200410A3 (en) | Pharmaceutical compositions for improving fertility using inhibitors of dipeptidyl peptidase in | |
| AP1411A (en) | Pyrrolo[2,3d] pyrimidine compositions and their use. | |
| WO2004021979A3 (en) | PYRROLO[2, 3-d]PYRIMIDINE-4-YL AND PURIN-6-YL UREA COMPOUNDS | |
| ZA200104697B (en) | Compositions and methods for amelioration of human female sexual dysfunction. | |
| BR0010220A (pt) | Compostos de pirimidinona | |
| MY141651A (en) | Nep inhibitors for the treatment of female sexual dysfunction | |
| WO2002002560A3 (en) | Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv) | |
| BG102879A (en) | Carbolin derivatives | |
| WO2003022216A3 (en) | Biaryl substituted purine derivatives as potent antiproliferative agents | |
| SI1075477T1 (en) | Novel Benzonaphthyridine-N-oxides | |
| FR2792938B1 (fr) | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV | |
| EP1233951A4 (en) | 3,4-DIHYDRO (1H) CHINAZOLIN-2-ON COMPOUNDS AS CSBP / P38 KINASE INHIBITORS | |
| EA200400808A1 (ru) | СПОСОБ ИНДУЦИРОВАНИЯ ОВУЛЯЦИИ С ИСПОЛЬЗОВАНИЕМ НЕПОЛИПЕПТИДНОГО МОДУЛЯТОРА УРОВНЕЙ цАМФ | |
| AU2001261835A1 (en) | Method of treating vaginal dryness with nicotinic acetylcholine receptor agonists | |
| WO2001091741A3 (en) | Compositions containing hexitol and an antiproliferative agent | |
| BR0108454A (pt) | Métodos para identificação e uso de antagonistas de receptor de adenosina a(2b) papa mediar a proliferação celular em mamìferos | |
| EP1201765A3 (en) | Cellular kinases involved in cytomegalovirus infection and their inhibition | |
| EP1235814A4 (en) | 3,4-DIHYDRO- (1H) QUINAZOLINE-2-ONE COMPOUNDS FOR USE AS CSBP / p38 KINASE INHIBITORS |