AU4406096A - Paramagnetic complexes of N-alkyl-N-hydroxylamides of organicacids and emulsions containing same for magnetic resonance imaging (MRI) - Google Patents

Paramagnetic complexes of N-alkyl-N-hydroxylamides of organicacids and emulsions containing same for magnetic resonance imaging (MRI)

Info

Publication number
AU4406096A
AU4406096A AU44060/96A AU4406096A AU4406096A AU 4406096 A AU4406096 A AU 4406096A AU 44060/96 A AU44060/96 A AU 44060/96A AU 4406096 A AU4406096 A AU 4406096A AU 4406096 A AU4406096 A AU 4406096A
Authority
AU
Australia
Prior art keywords
emulsion
group
subject
complex
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU44060/96A
Other languages
English (en)
Inventor
William P. Cacheris
Raymond C Grabiak
Albert C Lee
Thomas J. Richard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemagen PFC LP
Original Assignee
Hemagen PFC LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemagen PFC LP filed Critical Hemagen PFC LP
Publication of AU4406096A publication Critical patent/AU4406096A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/93—MRI contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AU44060/96A 1994-11-30 1995-11-09 Paramagnetic complexes of N-alkyl-N-hydroxylamides of organicacids and emulsions containing same for magnetic resonance imaging (MRI) Abandoned AU4406096A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/346,885 US5614170A (en) 1994-11-30 1994-11-30 Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
US346885 1994-11-30
PCT/US1995/014508 WO1996016679A1 (en) 1994-11-30 1995-11-09 Paramagnetic complexes of n-alkyl-n-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (mri)

Publications (1)

Publication Number Publication Date
AU4406096A true AU4406096A (en) 1996-06-19

Family

ID=23361430

Family Applications (1)

Application Number Title Priority Date Filing Date
AU44060/96A Abandoned AU4406096A (en) 1994-11-30 1995-11-09 Paramagnetic complexes of N-alkyl-N-hydroxylamides of organicacids and emulsions containing same for magnetic resonance imaging (MRI)

Country Status (6)

Country Link
US (1) US5614170A (ja)
EP (1) EP0794801A1 (ja)
JP (1) JPH11500413A (ja)
AU (1) AU4406096A (ja)
CA (1) CA2205232A1 (ja)
WO (1) WO1996016679A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028108A (en) * 1998-10-22 2000-02-22 America Home Products Corporation Propofol composition comprising pentetate
EP1572639A4 (en) 2002-01-24 2006-08-09 Barnes Jewish Hospital IMAGING AGENTS TARGETING INTEGRINS
US7279150B2 (en) * 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
US6869591B2 (en) * 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
CA2569461A1 (en) 2004-06-09 2005-12-29 Kereos, Inc. Lipophilic derivatives of chelate monoamides
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
LU503039B1 (en) * 2022-11-11 2024-05-13 Teresa Carlomagno Novel photocleavable spin-labels
CN115947672B (zh) * 2023-01-04 2024-02-27 成都威斯津生物医药科技有限公司 用于递送药物的化合物、脂质体及药物载体

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
JPS5331209B2 (ja) * 1973-10-05 1978-09-01
US4110474A (en) * 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4187252A (en) * 1977-08-26 1980-02-05 Suntech, Inc. Tetramethylpentane blood substitutes
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
CA1187882A (en) * 1981-11-27 1985-05-28 Kazumasa Yokoyama Perfluoro compound and emulsion thereof
US4443480A (en) * 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
EP0103358B1 (en) * 1982-08-07 1986-10-08 Green Cross Corporation Perfluoro-1-azatricyclic amine compound
US4534978A (en) * 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
CA1257828A (en) * 1984-04-16 1989-07-25 William Mccormick Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4686024A (en) * 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5064636A (en) * 1989-10-19 1991-11-12 Li King C P Paramagnetic oil emulsions as enteric MRI contrast agents
US5120527A (en) * 1989-10-19 1992-06-09 King Chuen Peter Li Paramagnetic oil emulsions as mri contrast agents
US5154914A (en) * 1990-03-12 1992-10-13 Research Corporation Technologies, Inc. Methods of diagnostic image analysis using lipophilic contrast agents
US5217706A (en) * 1990-11-21 1993-06-08 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).

Also Published As

Publication number Publication date
JPH11500413A (ja) 1999-01-12
WO1996016679A1 (en) 1996-06-06
CA2205232A1 (en) 1996-06-06
EP0794801A1 (en) 1997-09-17
US5614170A (en) 1997-03-25

Similar Documents

Publication Publication Date Title
US5571498A (en) Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
US5439669A (en) Biological imaging emulsions containing alkyl- or alkylglycerophosphoryl choline surfactants and methods of use
US5980936A (en) Multiple emulsions comprising a hydrophobic continuous phase
DE69934827T2 (de) Amphipatische polycarboxylchelate und komplexe mit paramagnetischen metallen als mri kontrastmittel
US5679459A (en) Perfluorinated amphiphilic phosphorous compounds: liposomal compositions
US5833948A (en) Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
US5762910A (en) Liposoluble compounds useful as magnetic resonance imaging agents
DE3785054T2 (de) Stabile emulsionen von stark fluorierten, organischen verbindungen.
EP0956853B1 (de) Verwendung von Nanodispersionen in pharmazeutischen Endformulierungen
EP0594707A1 (en) COMPOSITIONS CONTAINING A FLUOROCOLE HYDROGEN AND A LIPOPHILE / FLUOROPHILE ORGANIC COMPOUND AND THEIR USE.
JPH0667468B2 (ja) 過フツ素化炭化水素の水中油型エマルシヨンおよびその安定化方法
WO1994009625A2 (en) Stabilization of fluorocarbon emulsions
Decato et al. Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery
WO1998005301A1 (en) Multiple emulsions comprising a hydrophobic continuous phase
WO1994021303A1 (en) Fluorocarbon compositions containing a visible or fluorescent label
US5614170A (en) Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
US5635539A (en) Stable emulsions of highly fluorinated organic compounds
US5582813A (en) Iodine-containing fluorocarbon contrast agents
EP0841896B1 (en) Reverse gels comprising a continuous fluorinated phase
EP0451103B1 (de) Parenteral applizierbare Liposomenformulierung aus synthetischen Lipiden
WO1995028146A1 (en) Fluorochemical emulsions containing 1,3-dialkylglycerophosphoryl choline surfactants and methods of use
EP0494616A1 (de) Kontrastmittel für die MR-Diagnostik
JP2583066B2 (ja) Ａｒａ−Ｃ誘導体の新規な医療用製剤
AU710142B2 (en) Fluorocarbon emulsions with reduced pulmonary gas-trapping properties
CA2156922C (en) Fluorocarbon emulsions with reduced pulmonary gas-trapping properties