AU3516899A - Method and probes for the detection of chromosome aberrations - Google Patents

Method and probes for the detection of chromosome aberrations

Info

Publication number
AU3516899A
AU3516899A AU35168/99A AU3516899A AU3516899A AU 3516899 A AU3516899 A AU 3516899A AU 35168/99 A AU35168/99 A AU 35168/99A AU 3516899 A AU3516899 A AU 3516899A AU 3516899 A AU3516899 A AU 3516899A
Authority
AU
Australia
Prior art keywords
probes
detection
chromosome aberrations
aberrations
chromosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU35168/99A
Other languages
English (en)
Inventor
Kim Adelhorst
Kirsten Vang Nielsen
Karl-Johan Pluzek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dako Denmark ApS
Original Assignee
Dako AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dako AS filed Critical Dako AS
Publication of AU3516899A publication Critical patent/AU3516899A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6841In situ hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
AU35168/99A 1998-05-04 1999-05-04 Method and probes for the detection of chromosome aberrations Abandoned AU3516899A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK61598 1998-05-04
DK615/98 1998-05-04
PCT/DK1999/000245 WO1999057309A1 (en) 1998-05-04 1999-05-04 Method and probes for the detection of chromosome aberrations

Publications (1)

Publication Number Publication Date
AU3516899A true AU3516899A (en) 1999-11-23

Family

ID=8095582

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35168/99A Abandoned AU3516899A (en) 1998-05-04 1999-05-04 Method and probes for the detection of chromosome aberrations

Country Status (6)

Country Link
US (3) US7105294B2 (US20060160106A1-20060720-C00005.png)
EP (1) EP1078098A1 (US20060160106A1-20060720-C00005.png)
JP (1) JP2002513587A (US20060160106A1-20060720-C00005.png)
AU (1) AU3516899A (US20060160106A1-20060720-C00005.png)
CA (1) CA2327542C (US20060160106A1-20060720-C00005.png)
WO (1) WO1999057309A1 (US20060160106A1-20060720-C00005.png)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0878552A1 (en) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
WO1999057309A1 (en) * 1998-05-04 1999-11-11 Dako A/S Method and probes for the detection of chromosome aberrations
US6613567B1 (en) * 2000-09-15 2003-09-02 Isis Pharmaceuticals, Inc. Antisense inhibition of Her-2 expression
US20030129626A1 (en) 2001-09-24 2003-07-10 Nielsen Kirsten Vang Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
CA2724638C (en) 2008-05-27 2020-02-18 Dako Denmark A/S Hybridization compositions and methods comprising a polar aprotic solvent
US8352194B1 (en) 2008-06-17 2013-01-08 University Of South Florida Method to identify cancer fusion genes
US20100068701A1 (en) * 2008-09-12 2010-03-18 Yamada N Alice Chromosome labeling method
EP2401395A1 (en) 2009-02-26 2012-01-04 Dako Denmark A/S Compositions and methods for rna hybridization applications
US20130040294A1 (en) 2009-12-02 2013-02-14 Steen H. Matthiesen Compositions and methods for performing hybridizations with no denaturation
WO2011134474A1 (en) * 2010-04-30 2011-11-03 Exiqon A/S In situ hybridization method and buffer
EP2458365B1 (en) * 2010-11-24 2019-04-10 Milestone S.r.l. A two-step method and system for cold formalin fixation of organic tissue samples
US10662465B2 (en) 2011-09-30 2020-05-26 Agilent Technologies, Inc. Hybridization compositions and methods using formamide
US11118226B2 (en) 2011-10-21 2021-09-14 Agilent Technologies, Inc. Hybridization compositions and methods
KR20170007181A (ko) 2015-07-10 2017-01-18 3스캔 인크. 조직학적 염색제의 공간 다중화
DK3350343T3 (da) 2015-09-16 2020-07-20 Petaomics Inc Fremgangsmåder og sammensætninger til genommålberigelse og selektiv dna-sekventering
WO2021207062A1 (en) * 2020-04-07 2021-10-14 Advanced Cell Diagnostics, Inc. Methods for detecting target nucleic acids by in situ hybridization and a kit thereof

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260433A (en) 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
USRE35491E (en) 1982-11-04 1997-04-08 The Regents Of The University Of California Methods and compositions for detecting human tumors
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4681840A (en) 1984-01-18 1987-07-21 The United States Of America As Represented By The Secretary Of Commerce Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US4849505A (en) 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4843122A (en) 1984-01-30 1989-06-27 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4849208A (en) 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US4785086A (en) 1985-01-17 1988-11-15 Integrated Genetics, Inc. Test for Campylobacter
US6083709A (en) 1985-08-21 2000-07-04 Osi Pharmaceuticals, Inc. Immunoassay for detection of mutant P53 polypeptide in serum
GB8529014D0 (en) 1985-11-25 1986-01-02 Biogen Nv Enhanced secretion of heterologous proteins
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US6872817B1 (en) * 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US6344315B1 (en) * 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5721098A (en) 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
US4912034A (en) 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US4892817A (en) 1987-09-21 1990-01-09 Biogenex Laboratories Stable phosphatase substrate composition
US6203977B1 (en) * 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US5079147A (en) 1989-03-13 1992-01-07 The Wistar Institute Of Anatomy And Biology Diagnostic probes and methods for using same to detect breast cancer
US5198338A (en) 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5242795A (en) 1989-07-03 1993-09-07 Temple University TCL-5 gene rearrangement involved in T-cell leukemia and melanoma
US8592155B2 (en) * 1989-07-19 2013-11-26 The Regents Of The University Of California Method of detecting genetic deletions identified with chromosomal abnormalities
US5149628A (en) 1989-11-15 1992-09-22 Temple University Methods for detecting bcl-3 gene in human leukemias
US5695976A (en) 1989-12-18 1997-12-09 Novo Nordisk A/S Stable integration of DNA in bacterial genomes
US5955367A (en) 1989-12-18 1999-09-21 Abbott Laboratories Production of bacillus thuringiensis integrants
CA2037349C (en) 1990-03-26 2008-06-17 James G. Wetmur Branch migration of nucleotides
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US5506350A (en) 1990-09-20 1996-04-09 Bittner; Michael L. Production of chromosome region specific DNA sequences and transamination
US6277569B1 (en) * 1990-09-20 2001-08-21 Vysis, Inc. Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
US5789161A (en) 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
US5258507A (en) 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
US5512433A (en) 1990-11-08 1996-04-30 Vysis, Inc. Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes
JP3122821B2 (ja) 1990-11-21 2001-01-09 ピカー インターナショナル インコーポレイテッド 垂直格納コリメーターを備えた核医学カメラ用ガントリ装置
US5538869A (en) 1990-12-13 1996-07-23 Board Of Regents, The University Of Texas System In-situ hybridization probes for identification and banding of specific human chromosomes and regions
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
JPH06507785A (ja) 1991-03-20 1994-09-08 ザ ソールク インスチチュート フォア バイオロジカル スタディズ 染色体異常を確認する分析方法
WO1992021032A1 (en) 1991-05-24 1992-11-26 The Regents Of The University Of California Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
ATE191512T1 (de) 1991-07-31 2000-04-15 Vysis Inc Nukleinsäure sonden welche bei nachweis von shigellabakterien verwendbar sind
US6025126A (en) 1991-10-28 2000-02-15 Arch Development Corporation Methods and compositions for the detection of chromosomal aberrations
WO1993012136A1 (en) 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
US6040140A (en) 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
US5633135A (en) 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
ATE205542T1 (de) 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US5965362A (en) * 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
FR2691475B1 (fr) 1992-05-20 1995-03-24 Centre Nat Rech Scient Séquence d'ADN des produits de fusion résultant de la translocation chromosomique récurrente t(11;22) (q24;q12) associée au développement d'un groupe de tumeurs cancéreuses.
DE4216949C2 (de) 1992-05-22 1997-07-24 Christoph Prof Dr Dr Cremer Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben
US6121419A (en) 1992-06-17 2000-09-19 Arch Development Corp. Compositions and methods for detecting gene rearrangements and translocations
US5487970A (en) 1992-06-17 1996-01-30 Arch Development Corp. Compositions and methods for detecting gene rearrangements and translocations
US5538846A (en) 1992-09-17 1996-07-23 Meeker; Timothy C. BCL-1 locus nucleic acid probes and assay methods
US5547838A (en) 1992-10-01 1996-08-20 Life Technologies, Inc. Method for the rapid and ultra-sensitive detection of leukemic cells
WO1994009022A1 (en) 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
US5492837A (en) 1993-08-27 1996-02-20 Biogenex Laboratories Mounting medium for microscope slide preparations
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US6136540A (en) * 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
WO1995011313A1 (en) 1993-10-18 1995-04-27 Amoco Corporation Control compositions for determination of molecular cytogenetic abnormalities with dna probes
WO1995013398A1 (en) * 1993-11-12 1995-05-18 Oncor, Inc. Detection of bladder cancer
US5529925A (en) * 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5622829A (en) 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5846749A (en) 1994-10-12 1998-12-08 The Regents Of The University Of California Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
GB9501386D0 (en) 1995-01-23 1995-03-15 Hsc Res Dev Lp Sequence of a af1q cdna
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
EP0727487A1 (en) * 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multiple-tumor aberrant growth genes
IT1275862B1 (it) 1995-03-03 1997-10-24 Consiglio Nazionale Ricerche Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento
US5567586A (en) 1995-05-18 1996-10-22 Thomas Jefferson University Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region
US5684142A (en) 1995-06-07 1997-11-04 Oncor, Inc. Modified nucleotides for nucleic acid labeling
US6218529B1 (en) * 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5801032A (en) 1995-08-03 1998-09-01 Abbott Laboratories Vectors and process for producing high purity 6,12-dideoxyerythromycin A by fermentation
US5756294A (en) 1995-09-25 1998-05-26 Oncormed, Inc. Susceptibility mutation for breast and ovarian cancer
EP0870055B1 (en) * 1995-10-12 2007-05-16 LANSDORP, Peter, M. Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule
US5801021A (en) * 1995-10-20 1998-09-01 The Regents Of The University Of California Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
US5892010A (en) 1996-07-15 1999-04-06 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
AU7210196A (en) * 1995-11-16 1997-06-05 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US5888733A (en) 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US5700921A (en) 1995-11-27 1997-12-23 Vector Laboratories Labeling nucleic acids
US6007994A (en) * 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US5759781A (en) 1995-12-22 1998-06-02 Yale University Multiparametric fluorescence in situ hybridization
US5654155A (en) 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
DE19610255B4 (de) 1996-03-15 2004-11-04 Universität Heidelberg Verfahren zur Herstellung von Nukleinsäuresequenzen und Verfahren zum Nachweis von Translokationen zwischen Chromosomen
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5925519A (en) * 1996-06-03 1999-07-20 The Regents Of The University Of California Genetic alterations associated with prostate cancer
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
EP0825198A1 (en) * 1996-08-22 1998-02-25 K.U. Leuven Research & Development Plag gene family and tumorigenesis
WO1998020143A1 (en) 1996-11-05 1998-05-14 Abbott Laboratories Reagents and methods useful for detecting diseases of the lung
US5804384A (en) 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
GB9626074D0 (en) * 1996-12-16 1997-02-05 Cytocell Ltd Nucleic acids amplification assay
US5837466A (en) 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
US20030096255A1 (en) * 1997-02-19 2003-05-22 Felix Carolyn A. Methods and kits for analysis of chromosomal rearrangements associated with cancer
US6368791B1 (en) * 1997-02-19 2002-04-09 The Children's Hospital Of Philadelphia Methods and kits for analysis of chromosomal rearrangements associated with leukemia
GB9704054D0 (en) * 1997-02-27 1997-04-16 Univ Cambridge Tech Assay
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
EP0878552A1 (en) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6686165B2 (en) * 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
US6352829B1 (en) * 1997-05-21 2002-03-05 Clontech Laboratories, Inc. Methods of assaying differential expression
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6358682B1 (en) * 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
WO1999057309A1 (en) * 1998-05-04 1999-11-11 Dako A/S Method and probes for the detection of chromosome aberrations
US6037129A (en) 1998-05-28 2000-03-14 Medical University Of South Carolina Multi-marker RT-PCR panel for detecting metastatic breast cancer
US6573043B1 (en) * 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6414133B1 (en) * 1998-10-13 2002-07-02 Ventana Medical Systems, Inc. Multiple fusion probes
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6174681B1 (en) * 1999-03-05 2001-01-16 Mayo Foundation For Medical Education And Research Method and probe set for detecting cancer
WO2000062804A2 (en) * 1999-04-15 2000-10-26 The Regents Of The University Of California Identification of sortase gene
US6689875B1 (en) * 1999-06-09 2004-02-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Molecular characterization of chromosome translocation t(11;18)(q21;q21) and its correlation to carcinogenesis
US20030021813A1 (en) * 1999-08-04 2003-01-30 Chovan Linda E. Essential bacteria genes and genome scanning in Haemophilus influenzae for the identification of 'essential genes'
EP1218547A4 (en) * 1999-10-15 2005-04-20 Ventana Med Syst Inc METHOD FOR DETECTING UNIQUE GENE IN SITU COPIES
DE10002803A1 (de) * 2000-01-24 2001-08-02 Conbio Lizenzverwertungsgesell System zur internen qualitativen und quantitativen Validierung von Markerindices
JP2004512012A (ja) * 2000-04-04 2004-04-22 メディカル リサーチ カウンシル 細胞検出法
AU2001266915A1 (en) * 2000-06-14 2001-12-24 Case Western Reserve University Probes for chondrogenesis
US6903187B1 (en) * 2000-07-21 2005-06-07 Allergan, Inc. Leucine-based motif and clostridial neurotoxins
US20030039658A1 (en) * 2000-08-18 2003-02-27 Mario Estable MCEF, a novel transcription factor
UA83458C2 (uk) * 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
US6391592B1 (en) * 2000-12-14 2002-05-21 Affymetrix, Inc. Blocker-aided target amplification of nucleic acids
EP1362124B1 (en) * 2001-02-20 2011-07-06 Vysis, Inc. Methods and probes for the detection of cancer
EP1417297A4 (en) * 2001-07-13 2007-08-22 Whitehead Biomedical Inst LEUCEMIGENES TRANSCRIPTION FACTORS
EP1451318A4 (en) * 2001-10-12 2007-06-27 Perkinelmer Las Inc NUCLEIC ACID COMPILATIONS, NETWORKS AND METHODS OF USE THEREOF
US20040029142A1 (en) * 2002-02-11 2004-02-12 Schon Eric A. Concatenation-based nucleic acid detection compositions and methods
US20040110227A1 (en) * 2002-03-19 2004-06-10 Erez Levanon Methods and systems for identifying putative fusion transcripts, polypeptides encoded therefrom and polynucleotide sequences related thereto and methods and kits utilizing same

Also Published As

Publication number Publication date
US7642057B2 (en) 2010-01-05
CA2327542C (en) 2011-11-22
US20060160106A1 (en) 2006-07-20
CA2327542A1 (en) 1999-11-11
US7105294B2 (en) 2006-09-12
US7368245B2 (en) 2008-05-06
US20080187934A1 (en) 2008-08-07
WO1999057309A1 (en) 1999-11-11
US20040043383A1 (en) 2004-03-04
EP1078098A1 (en) 2001-02-28
JP2002513587A (ja) 2002-05-14

Similar Documents

Publication Publication Date Title
AU5778000A (en) System and method for molecular sample measurement
AU1821201A (en) System and method for determining whether wagers have been altered
AU3516899A (en) Method and probes for the detection of chromosome aberrations
AU2733700A (en) Method and apparatus for measurement of microtome performance
AU5039399A (en) Method and arrangement for measuring fluid
AU7349198A (en) Nucleic acid probes for the detection and identification of fungi
AU2457299A (en) Advertising device and method for use at point of sale
AU1817500A (en) Protective sheath and method for ultrasonic probes
AU6737600A (en) System and method for displaying results of search
AU4388099A (en) Non-contact test method and apparatus
AU3294897A (en) Method and apparatus for sensing the presence of microbes
AU3606799A (en) Method and arrangement for measuring the structures of an object
AU6061100A (en) Object inspection and/or modification system and method
HK1046047A1 (zh) 用於交易工具的系統和方法
AU4221700A (en) Method and apparatus for determining signal path
AU1501697A (en) Improved method for the detection of protein
AU4994399A (en) System for testing properties of materials
AU5583400A (en) Method for performing radar measurements and use of the method for calibrating the radar system
AU5008996A (en) Method for the qualitative and quantitative detection of dna damage
AU5072199A (en) Method and instrument for level measurements
AU2261601A (en) Method for the simultaneous analysis and detection of multiple analytes by microidentification
AU5925300A (en) Post-seal inspection system and method
AU4456297A (en) Oligonucleotide probes for the detection of bifidobacteria
AU5366296A (en) Methods for the detection of paracoccidioides
AU3087699A (en) Method and apparatus for testing surfaces

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase