AU3458401A - Compositions and methods for treatment of cancer - Google Patents
Compositions and methods for treatment of cancer Download PDFInfo
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- AU3458401A AU3458401A AU34584/01A AU3458401A AU3458401A AU 3458401 A AU3458401 A AU 3458401A AU 34584/01 A AU34584/01 A AU 34584/01A AU 3458401 A AU3458401 A AU 3458401A AU 3458401 A AU3458401 A AU 3458401A
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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Landscapes
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Applications Claiming Priority (5)
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| US17795100P | 2000-01-25 | 2000-01-25 | |
| US60177951 | 2000-01-25 | ||
| US19576100P | 2000-04-10 | 2000-04-10 | |
| US60195761 | 2000-04-10 | ||
| PCT/US2001/002622 WO2001055178A2 (en) | 2000-01-25 | 2001-01-25 | Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer |
Publications (1)
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| AU3458401A true AU3458401A (en) | 2001-08-07 |
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| EP (1) | EP1263780A2 (enExample) |
| JP (1) | JP2003523207A (enExample) |
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| WO (1) | WO2001055178A2 (enExample) |
| ZA (1) | ZA200205191B (enExample) |
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| US20040141983A1 (en) | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
| US6762020B1 (en) | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| US20030068636A1 (en) * | 2001-06-21 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions, kits and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
| CN100516211C (zh) | 2002-02-20 | 2009-07-22 | 希森美康株式会社 | 用于持家基因mRNA检测的核酸扩增用引物和使用该引物的检查方法 |
| EP1596806A4 (en) * | 2003-01-27 | 2007-08-29 | Biogen Idec Inc | COMPOSITIONS AND METHODS FOR TREATING CANCER USING IGSF9 AND LIV-1 |
| WO2004067564A2 (en) * | 2003-01-29 | 2004-08-12 | Protein Design Labs, Inc. | Compositions against cancer antigen liv-1 and uses thereof |
| EP1691836B1 (en) | 2003-11-13 | 2012-02-22 | Sutter West Bay Hospitals | Anti-pecam therapy for metastasis suppression |
| FR2863275B1 (fr) * | 2003-12-09 | 2007-08-10 | Biomerieux Sa | Procede pour le diagnostic/pronostic du cancer du sein |
| JPWO2005063301A1 (ja) * | 2003-12-26 | 2007-07-19 | 平野 俊夫 | Emt誘導剤 |
| US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
| JPWO2005095942A1 (ja) * | 2004-03-30 | 2008-02-21 | 独立行政法人理化学研究所 | レーザーアブレーションを用いた生体試料の分析方法およびその装置 |
| CN101128586A (zh) | 2004-12-22 | 2008-02-20 | 健泰科生物技术公司 | 制备可溶性多跨膜蛋白的方法 |
| BRPI0710616A2 (pt) * | 2006-04-13 | 2011-08-16 | Novartis Vaccines & Diagnostic | métodos para tratar, diagnosticar ou detectar cáncer |
| US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| US8097423B2 (en) * | 2007-07-30 | 2012-01-17 | Institute Of Virology | MN/CA IX and breast cancer therapy |
| US20100092894A1 (en) * | 2008-10-14 | 2010-04-15 | Weihong Liu | Bottom Antireflective Coating Compositions |
| MX2012005168A (es) | 2009-11-05 | 2012-06-08 | Genentech Inc | Metodos y composicion para secrecion de polipeptidos heterologos. |
| EP2606349A4 (en) * | 2010-08-20 | 2014-04-30 | Univ Jefferson | AGENTS FOR CANCER DIAGNOSIS AND CANCER THERAPY |
| CA2819038C (en) | 2010-12-06 | 2023-10-17 | Seattle Genetics, Inc. | Humanized antibodies to liv-1 and use of same to treat cancer |
| GB2523211B (en) | 2012-01-27 | 2020-03-18 | Univ Jefferson | MCT protein inhibitor-related prognostic and therapeutic methods |
| WO2014172627A1 (en) | 2013-04-19 | 2014-10-23 | Thomas Jefferson University | Caveolin-1 related methods for treating glioblastoma with temozolomide |
| MX2016011637A (es) | 2014-03-14 | 2017-04-13 | Genentech Inc | Metodos y composiciones para secrecion de polipeptidos heterologos. |
| MA45324A (fr) | 2016-03-15 | 2019-01-23 | Seattle Genetics Inc | Polythérapie utilisant un adc-liv1 et un agent chimiothérapeutique |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5720937A (en) * | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| WO1990014357A1 (en) | 1989-05-19 | 1990-11-29 | Genentech, Inc. | Her2 extracellular domain |
| CA2132500A1 (en) | 1994-09-20 | 1996-03-21 | David Lockwood Manning | Methods for predicting the behaviour of breast tumours |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ATE418536T1 (de) | 1996-08-12 | 2009-01-15 | Celgene Corp | Neue immunotherapeutische mittel und deren verwendung in der reduzierung von cytokinenspiegel |
| KR100628846B1 (ko) | 1996-10-18 | 2006-09-29 | 제넨테크, 인크. | 항-ErbB2 항체 |
| US5860935A (en) | 1996-10-29 | 1999-01-19 | Novid Inc. | Game apparatus and method for monitoring psycho-physiological responses to questions |
| CA2289116A1 (en) | 1997-05-06 | 1998-11-12 | Human Genome Sciences, Inc. | Enterococcus faecalis polynucleotides and polypeptides |
| WO1999006673A1 (en) | 1997-07-30 | 1999-02-11 | Eg & G Sealol, Inc. | Improved brush seal and method of making same |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| DE19813839A1 (de) | 1998-03-20 | 1999-09-23 | Metagen Gesellschaft Fuer Genomforschung Mbh | Menschliche Nukleinsäuresequenzen aus Brusttumorgewebe |
| IL138034A0 (en) | 1998-03-27 | 2001-10-31 | Genentech Inc | Apo-2 ligand-anti-her-2 antibody synergism |
| EP1121437B1 (en) | 1998-10-15 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Metastatic breast and colon cancer regulated genes |
| US6579973B1 (en) | 1998-12-28 | 2003-06-17 | Corixa Corporation | Compositions for the treatment and diagnosis of breast cancer and methods for their use |
| CA2296792A1 (en) | 1999-02-26 | 2000-08-26 | Genset S.A. | Expressed sequence tags and encoded human proteins |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US6649342B1 (en) * | 1999-03-15 | 2003-11-18 | Eos Biotechnology, Inc. | Methods of diagnosing breast cancer, compositions, and methods of screening for breast cancer modulators |
| AU3752700A (en) | 1999-03-15 | 2000-10-04 | Eos Biotechnology, Inc. | Novel methods of diagnosing and treating breast cancer, compositions, and methods of screening for breast cancer modulators |
| US6762020B1 (en) * | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| US20040141983A1 (en) * | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
| AU3632900A (en) | 1999-03-26 | 2000-10-16 | Human Genome Sciences, Inc. | 50 human secreted proteins |
| EP1212343A4 (en) | 1999-09-03 | 2004-11-03 | Human Genome Sciences Inc | 52 HUMAN SECRETED PROTEINS |
| US6780586B1 (en) * | 1999-11-29 | 2004-08-24 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| US6750013B2 (en) * | 1999-12-02 | 2004-06-15 | Protein Design Labs, Inc. | Methods for detection and diagnosing of breast cancer |
| WO2002016939A2 (en) * | 2000-08-18 | 2002-02-28 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer and screening for cancer modulators |
| JP2005503760A (ja) * | 2001-01-24 | 2005-02-10 | プロテイン デザイン ラブス, インコーポレイテッド | 乳癌の診断方法、組成物および乳癌のモジュレーターのスクリーニング方法 |
| WO2004067564A2 (en) | 2003-01-29 | 2004-08-12 | Protein Design Labs, Inc. | Compositions against cancer antigen liv-1 and uses thereof |
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- 2001-01-25 IL IL15059201A patent/IL150592A0/xx unknown
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- 2001-01-25 EP EP01906709A patent/EP1263780A2/en not_active Withdrawn
- 2001-01-25 CA CA002395832A patent/CA2395832A1/en not_active Abandoned
- 2001-01-25 KR KR1020027009510A patent/KR20020073181A/ko not_active Ceased
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| IL202332A0 (en) | 2011-08-01 |
| US20080138345A1 (en) | 2008-06-12 |
| US20030215457A1 (en) | 2003-11-20 |
| ZA200205191B (en) | 2003-07-28 |
| US7982015B2 (en) | 2011-07-19 |
| US20070264267A1 (en) | 2007-11-15 |
| CA2395832A1 (en) | 2001-08-02 |
| US7691566B2 (en) | 2010-04-06 |
| WO2001055178A2 (en) | 2001-08-02 |
| EP1263780A2 (en) | 2002-12-11 |
| IL150592A0 (en) | 2003-02-12 |
| MXPA02007190A (es) | 2003-02-12 |
| WO2001055178A9 (en) | 2002-04-04 |
| JP2003523207A (ja) | 2003-08-05 |
| KR20020073181A (ko) | 2002-09-19 |
| US7285382B2 (en) | 2007-10-23 |
| WO2001055178A3 (en) | 2002-03-07 |
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