AU3456099A - Methods and compositions for eliciting an immune response to a telomerase antigen - Google Patents

Methods and compositions for eliciting an immune response to a telomerase antigen

Info

Publication number
AU3456099A
AU3456099A AU34560/99A AU3456099A AU3456099A AU 3456099 A AU3456099 A AU 3456099A AU 34560/99 A AU34560/99 A AU 34560/99A AU 3456099 A AU3456099 A AU 3456099A AU 3456099 A AU3456099 A AU 3456099A
Authority
AU
Australia
Prior art keywords
eliciting
compositions
methods
immune response
telomerase antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU34560/99A
Other languages
English (en)
Inventor
Federico C.A. Gaeta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geron Corp
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of AU3456099A publication Critical patent/AU3456099A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4246—Telomerase or [telomerase reverse transcriptase [TERT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU34560/99A 1998-03-31 1999-03-30 Methods and compositions for eliciting an immune response to a telomerase antigen Abandoned AU3456099A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11200698P 1998-03-31 1998-03-31
US60112006 1998-03-31
PCT/US1999/006898 WO1999050392A1 (en) 1998-03-31 1999-03-30 Methods and compositions for eliciting an immune response to a telomerase antigen

Publications (1)

Publication Number Publication Date
AU3456099A true AU3456099A (en) 1999-10-18

Family

ID=22341634

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34560/99A Abandoned AU3456099A (en) 1998-03-31 1999-03-30 Methods and compositions for eliciting an immune response to a telomerase antigen

Country Status (6)

Country Link
US (1) US6440735B1 (enExample)
EP (1) EP1068296B1 (enExample)
JP (3) JP2002509716A (enExample)
AU (1) AU3456099A (enExample)
CA (1) CA2347067C (enExample)
WO (1) WO1999050392A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU781376B2 (en) * 1999-04-09 2005-05-19 Biomira Inc. Telomerase-specific cancer vaccine

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261836B1 (en) * 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6808880B2 (en) * 1996-10-01 2004-10-26 Geron Corporation Method for detecting polynucleotides encoding telomerase
US6475789B1 (en) * 1996-10-01 2002-11-05 University Technology Corporation Human telomerase catalytic subunit: diagnostic and therapeutic methods
US7585622B1 (en) 1996-10-01 2009-09-08 Geron Corporation Increasing the proliferative capacity of cells using telomerase reverse transcriptase
US6444650B1 (en) * 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
EP0841396B2 (en) * 1996-10-01 2012-04-11 Geron Corporation Human telomerase catalytic subunit
US6093809A (en) * 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US20050013825A1 (en) * 1997-04-18 2005-01-20 Geron Corporation Vaccine containing the catalytic subunit of telomerase for treating cancer
US7413864B2 (en) * 1997-04-18 2008-08-19 Geron Corporation Treating cancer using a telomerase vaccine
US7622549B2 (en) * 1997-04-18 2009-11-24 Geron Corporation Human telomerase reverse transcriptase polypeptides
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
US7402307B2 (en) 1998-03-31 2008-07-22 Geron Corporation Method for identifying and killing cancer cells
US6337200B1 (en) * 1998-03-31 2002-01-08 Geron Corporation Human telomerase catalytic subunit variants
US7030211B1 (en) 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
US20020142974A1 (en) * 1998-09-11 2002-10-03 Leonard D. Kohn Immune activation by double-stranded polynucleotides
WO2000025813A1 (en) 1998-10-29 2000-05-11 Dana-Farber Cancer Institute CANCER IMMUNOTHERAPHY AND DIAGNOSIS USING UNIVERSAL TUMOR ASSOCIATED ANTIGENS, INCLUDING hTERT
AU2001241533A1 (en) 2000-02-15 2001-08-27 The Regents Of The University Of California A universal vaccine and method for treating cancer employing telomerase reverse transcriptase
EP1257284A4 (en) * 2000-02-15 2005-12-21 Univ California UNIVERSAL VACCINE AND METHOD OF TREATING CANCER USING TELOMERASE REVERSE TRANSCRIPTASE
GB0031430D0 (en) 2000-12-22 2001-02-07 Norsk Hydro As Polypeptides
WO2004084936A2 (en) * 2003-02-06 2004-10-07 Cerus Corporation Modified free-living microbes, vaccine compositions and methods of use thereof
US7695725B2 (en) * 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
JP4545151B2 (ja) * 2003-02-06 2010-09-15 シーラス コーポレイション 非食細胞中への侵入について減弱化されているリステリア、そのリステリアを含むワクチン、およびそれらの使用法
US7842289B2 (en) * 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
JP2008507282A (ja) 2004-07-20 2008-03-13 アイソジェニス・インコーポレイテッド 自己免疫および自己抗原に関連する疾患の特異的阻害
CA2504451A1 (en) * 2004-08-10 2006-02-10 Geron Corporation Dendritic cell vaccines for treating cancer made from embryonic stem cells
EP1801202A4 (en) * 2004-09-03 2008-02-06 Medical & Biol Lab Co Ltd METHOD FOR PRODUCING A DENDRITIC CELL WITH ACQUIRED CTL-INDUCING SKILL
US20080064048A1 (en) * 2004-09-03 2008-03-13 Medical And Biological Laboratories, Co., Ltd. Methods for Selecting Proteins that are Readily Presented as Antigens on Dendritic Cells
WO2006072625A2 (en) 2005-01-06 2006-07-13 Novo Nordisk A/S Anti-kir combination treatments and methods
EP3312196B1 (en) 2005-03-23 2019-07-17 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
EP1748067A1 (en) * 2005-07-29 2007-01-31 Institut Pasteur Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes
RU2309753C1 (ru) * 2006-05-05 2007-11-10 ЗАО "РеМеТэкс" Комбинированный клеточный трансплантат на основе лимфокинактивированных киллеров и дендритных клеток, способ его получения и способ лечения и профилактики онкологических, инфекционных заболеваний и иммунодефицитных состояний
NZ576122A (en) 2006-09-26 2012-09-28 Genmab As Anti-cd38 plus corticosteroids plus a non-corticosteroid chemotherapeutic for treating tumors
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
US8858952B2 (en) 2009-02-19 2014-10-14 Mayo Foundation For Medical Education And Research Methods and materials for generating T cells
US8563307B2 (en) 2009-02-24 2013-10-22 James Wang Treatment of immunosuppression-related disorders
PL2536830T3 (pl) 2010-02-16 2020-02-28 Ultimovacs As Polipeptydy
ES2993335T3 (en) 2010-03-10 2024-12-27 Genmab As Monoclonal antibodies against c-met
US9714294B2 (en) 2010-05-27 2017-07-25 Genmab A/S Monoclonal antibodies against HER2 epitope
CA3051311A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
EP3613774A1 (en) 2010-06-09 2020-02-26 Genmab A/S Antibodies against human cd38
AU2011267106B2 (en) 2010-06-15 2015-05-14 Genmab A/S Human antibody drug conjugates against tissue factor
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
AU2012245116A1 (en) 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
JP6177231B2 (ja) 2011-04-20 2017-08-09 ゲンマブ エー／エス Ｈｅｒ２に対する二重特異性抗体
EP2699260B1 (en) 2011-04-20 2024-11-20 Genmab A/S Bispecifc antibodies against her2
TWI614340B (zh) 2011-09-28 2018-02-11 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
EP2929013B1 (en) 2012-12-06 2020-02-05 Stembios Technologies, Inc. Lgr5+ somatic stem cells
EP2746770A1 (en) 2012-12-21 2014-06-25 Stembios Technologies, Inc. Method for evaluating effect of action on subject based on stem celldynamics
US20170058043A1 (en) 2014-12-06 2017-03-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
UA120286C2 (uk) 2015-01-08 2019-11-11 Ґенмаб А/С Біспецифічне антитіло проти cd3 і cd20
US11020465B2 (en) 2016-03-04 2021-06-01 The Trustees Of Columbia University In The City Of New York Development of dual whole cell-based vaccine against pancreatic cancer
CN109906086A (zh) * 2016-08-02 2019-06-18 河谷细胞有限公司 树突细胞的转染及其方法
KR20220024974A (ko) * 2016-09-30 2022-03-03 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Tert 면역원성 조성물 및 이를 이용한 치료 방법
US11458169B2 (en) 2017-02-22 2022-10-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. TIM3-binding chimeric antigen receptors
KR20200027508A (ko) 2017-07-07 2020-03-12 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 돌연변이된 cd28 공동자극 도메인을 갖는 키메라 항원 수용체
AU2019205422B2 (en) 2018-01-08 2025-08-28 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods for targeting CD99-expressing cancers
JP7315244B2 (ja) 2018-01-09 2023-07-26 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Ｃｌｅｃ１２ａ発現癌を標的にするための組成物および方法
CN115315260A (zh) 2019-12-02 2022-11-08 新基公司 治疗癌症的疗法
US20230086675A1 (en) 2020-02-27 2023-03-23 H. Lee Moffitt Cancer Center And Research Institute, Inc Tumor-infiltrating lymphocytes with enhanced tumor reactivity
US11826386B2 (en) 2020-05-05 2023-11-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cancer
WO2024206155A1 (en) 2023-03-24 2024-10-03 Cornell University Utilizing t cells derived from tumor draining lymph nodes for chimeric antigen receptor (car) t cell therapy for the treatment of cancer

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0147689B1 (en) 1983-12-05 1990-09-19 Asahi Kasei Kogyo Kabushiki Kaisha A method of inducing antitumor immunocytes, and a process for producing antitumor immunocytes and antitumor immunocytes produced by the process
US6004807A (en) 1992-03-30 1999-12-21 Schering Corporation In vitro generation of human dendritic cells
WO1993020185A1 (en) 1992-04-01 1993-10-14 Steinman Ralph M Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
EP0633929B1 (en) 1992-04-01 2004-03-03 The Rockefeller University METHOD FOR $i(IN VITRO) PROLIFERATION OF DENDRITIC CELL PRECURSORS AND THEIR USE TO PRODUCE IMMUNOGENS
IL105503A (en) 1992-04-28 1999-05-09 Astra Ab Carbon peptide couplets capable of eliciting an immune response of T cells
US5639613A (en) 1992-05-13 1997-06-17 Board Of Regents, University Of Texas System Methods for cancer diagnosis and prognosis
US5645986A (en) * 1992-05-13 1997-07-08 Board Of Reagents, The University Of Texas System Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5629154A (en) 1993-11-12 1997-05-13 Geron Corporation Telomerase activity assays
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5648215A (en) 1992-05-13 1997-07-15 Board Of Regents, The University Of Texas System Telomerase diagnostic methods
US5587308A (en) 1992-06-02 1996-12-24 The United States Of America As Represented By The Department Of Health & Human Services Modified adeno-associated virus vector capable of expression from a novel promoter
AU4678993A (en) * 1992-07-16 1994-02-14 Board Of Trustees Of The Leland Stanford Junior University Methods for using dendritic cells to activate t cells
US6077519A (en) 1993-01-29 2000-06-20 University Of Pittsburgh Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients
CA2158281A1 (en) 1993-03-15 1994-09-29 Jay A. Berzofsky Peptide coated dendritic cells as immunogens
AU6816194A (en) * 1993-04-20 1994-11-08 Robinson, William S. Methods and materials for treatment of individuals infected with intracellular infectious agents
IT1264516B1 (it) 1993-05-31 1996-09-24 Biotop Sas Di Rita Cassarin Cellule dendritiche immortalizzate
DE4412794A1 (de) 1994-04-14 1995-12-14 Univ Ludwigs Albert Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens
AU710783B2 (en) 1994-06-14 1999-09-30 Board Of Trustees Of The Leland Stanford Junior University Methods for in vivo T cell activation by antigen-pulsed dendritic cells
US5972627A (en) 1994-06-15 1999-10-26 Systemix, Inc. Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby
JP3680219B2 (ja) 1994-06-28 2005-08-10 独立行政法人理化学研究所 癌細胞障害性ｔリンパ球の誘導培養方法
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5648219A (en) 1995-06-07 1997-07-15 Zymogenetics, Inc. Immortalized dendritic cells
US5643786A (en) 1995-01-27 1997-07-01 The United States Of America As Represented By The Department Of Health And Human Services Method for isolating dendritic cells
US6010905A (en) 1995-01-27 2000-01-04 The United States Of America As Represented By The Department Of Health & Human Services Method for inducing monocytes to exhibit the phenotype of activated myeloid dendritic cells
US5871728A (en) 1995-03-31 1999-02-16 University Of Pittsburgh Method of regulating dendritic cell maturation
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US6015554A (en) 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US5968506A (en) * 1995-08-04 1999-10-19 Geron Corporation Purified telomerase
AU7152296A (en) 1995-08-16 1997-03-12 Board Of Trustees Of The Leland Stanford Junior University Adult oligodendrocyte precursor cell compositions and methods
US5858777A (en) 1995-09-08 1999-01-12 Geron Corporation Methods and reagents for regulating telomere length and telomerase activity
AU1152397A (en) 1995-12-20 1997-07-14 Board Of Trustees Of The Leland Stanford Junior University Methods for in vivo t cell activation by antigen-pulsed dendritic cells
US6080409A (en) 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
JP2002515734A (ja) 1996-01-02 2002-05-28 カイロン コーポレイション 遺伝子改変された樹状細胞により媒介される免疫刺激
US6224870B1 (en) * 1997-01-24 2001-05-01 Genitrix, Ltd. Vaccine compositions and methods of modulating immune responses
ATE314462T1 (de) 1996-02-08 2006-01-15 Us Gov Health & Human Serv Verfahren zur transformation dendritischer zellen und aktivierung von t zellen
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
WO1997040182A1 (de) 1996-04-19 1997-10-30 Gabriele Pecher Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
US5770422A (en) 1996-07-08 1998-06-23 The Regents Of The University Of California Human telomerase
US5747317A (en) 1996-07-08 1998-05-05 Tularik Inc. Human telomerase RNA interacting protein gene
US6017527A (en) 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
JP2002514047A (ja) 1996-07-10 2002-05-14 イミュネックス・コーポレーション 樹状細胞を活性化する方法
WO1998007838A1 (en) 1996-08-21 1998-02-26 Mitsubishi Chemical Corporation Higher animal telomerase protein and gene encoding the same
CH689672A9 (de) 1996-10-01 2000-02-29 Geron Corp Katalytische Untereinheit menschlicher Telomerase.
US6261836B1 (en) * 1996-10-01 2001-07-17 Geron Corporation Telomerase
EP0841396B2 (en) 1996-10-01 2012-04-11 Geron Corporation Human telomerase catalytic subunit
US6093809A (en) 1996-10-01 2000-07-25 University Technology Corporation Telomerase
US5812477A (en) 1996-10-03 1998-09-22 Micron Technology, Inc. Antifuse detection circuit
WO1998014561A1 (en) 1996-10-04 1998-04-09 Becton Dickinson And Company Identification of a cd34+ bone marrow precursor for dendritic cells in blood and lymphoid tissues
AU4814997A (en) 1996-10-10 1998-05-05 Duke University Method of producing a thymic microenvironment that supports the development of dendritic cells
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
US5919656A (en) 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
US5962318A (en) 1996-11-15 1999-10-05 St. Jude Children's Research Hospital Cytotoxic T lymphocyte-mediated immunotherapy
WO1998023759A2 (en) 1996-11-26 1998-06-04 Baylor College Of Medicine Identification of inhibitors that prevent access of telomerase to chromosomal terminus
WO1998037181A2 (en) 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
US20010007659A1 (en) 1997-04-17 2001-07-12 The University Of California Use of lentiviral vectors for antigen presentation in dendritic cells
AUPO723097A0 (en) 1997-06-06 1997-07-03 Australian National University, The A method for culturing cells
CA2294646A1 (en) 1997-06-20 1998-12-30 Bayer Aktiengesellschaft Human catalytic telomerase sub-unit and its diagnostic and therapeutic use
AU750980B2 (en) 1997-06-25 2002-08-01 Regents Of The University Of California, The Rice beta-glucanase enzymes and genes
EP0917579A1 (en) 1997-07-01 1999-05-26 Cambia Biosystems LLC Vertebrate telomerase genes and proteins and uses thereof
AU1220599A (en) 1997-11-14 1999-06-07 Hemosol Inc. Method for the production and use of dendritic cells
CA2347067C (en) 1998-03-31 2013-09-17 Geron Corporation Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer
US6300131B1 (en) 1998-04-06 2001-10-09 Johns Hopkins University Telomerase-associated proteins
JP2002517409A (ja) 1998-06-02 2002-06-18 デンドレオン コーポレイション 抗原提示細胞組成物の調製およびインビボ投与のための方法
US6277613B1 (en) 1998-06-10 2001-08-21 The Rockefeller University TRF1 binding protein, methods of use thereof
WO1999063945A2 (en) 1998-06-12 1999-12-16 Sloan-Kettering Institute For Cancer Research Vaccination strategy to prevent and treat cancers
US7030211B1 (en) 1998-07-08 2006-04-18 Gemvax As Antigenic peptides derived from telomerase
GB9816781D0 (en) 1998-07-31 1998-09-30 Univ London Herpes virus vectors for dendritic cells
WO2000015264A1 (en) 1998-09-15 2000-03-23 University Of Pittsburgh Of The Commonwealth System Of Higher Education In situ injection of antigen-presenting cells with genetically enhanced cytokine expression
WO2000025813A1 (en) 1998-10-29 2000-05-11 Dana-Farber Cancer Institute CANCER IMMUNOTHERAPHY AND DIAGNOSIS USING UNIVERSAL TUMOR ASSOCIATED ANTIGENS, INCLUDING hTERT
GB9824306D0 (en) 1998-11-05 1998-12-30 Isis Innovation Method for producing dendritic dells
WO2000061766A2 (en) * 1999-04-09 2000-10-19 Biomira, Inc. Telomerase-specific cancer vaccine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU781376B2 (en) * 1999-04-09 2005-05-19 Biomira Inc. Telomerase-specific cancer vaccine

Also Published As

Publication number Publication date
CA2347067C (en) 2013-09-17
JP2002509716A (ja) 2002-04-02
EP1068296A1 (en) 2001-01-17
EP1068296A4 (en) 2003-06-04
CA2347067A1 (en) 1999-10-07
US6440735B1 (en) 2002-08-27
EP1068296B1 (en) 2011-08-10
JP2007137889A (ja) 2007-06-07
WO1999050392A1 (en) 1999-10-07
JP2006020648A (ja) 2006-01-26

Similar Documents

Publication Publication Date Title
AU3456099A (en) Methods and compositions for eliciting an immune response to a telomerase antigen
AU2001255196A1 (en) Compositions and methods for enhancing immunogenicity of antigens
IL122340A0 (en) Helicobacter pylori antigens and vaccine compositions
AU4518196A (en) Adjuvant-incorporated cellular antigens: conjugation and methods
AU3760100A (en) Immunostimulatory nucleic acids and antigens
AU5784100A (en) Method for enhancing an immune response
HUP9903770A3 (en) Method and composition for reconforming multi-epitopic antigens to initiate an immune response
AU3159499A (en) Antigen preparation and use
AU1940301A (en) Tick antigens and compositions and methods comprising them
AU2002215014A1 (en) Method and device for the preparation of fuels
AU2001261005A1 (en) Immune mediators and related methods
AU2247095A (en) Cellular immune response-specific antigens and uses therefor
AU2003204353A1 (en) Methods and compositions for enhancing immune response and for the production of in vitro mabs
AU2273397A (en) Methods and compositions for modulating an immune response
AU7308200A (en) Novel hev antigenic peptide and methods
AU1597001A (en) Compositions and methods for modifying an immune response against tropomyosin
CZ20011896A3 (cs) Imunogenní prostředek a protilátka
AU2002239441A1 (en) Methods and compositions for inducing cell-mediated immune responses
AU2001266845A1 (en) Modulation of immune response and methods based thereon
AU7585998A (en) Controlling immune response to specific antigens
AU7358098A (en) Radioisotope concentrator methods and compositions
AU8513698A (en) Methods and compositions for designing vaccines
AU2002248646A1 (en) Compositions and methods for modulating an immune response
GB2351905B (en) Eliciting improved immune responses
AU5072501A (en) Helicobacter pylori antigens: fusion of hpaa and hpa44

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase