AU2435199A - Farnesyl transferase inhibitors - Google Patents

Farnesyl transferase inhibitors

Info

Publication number
AU2435199A
AU2435199A AU24351/99A AU2435199A AU2435199A AU 2435199 A AU2435199 A AU 2435199A AU 24351/99 A AU24351/99 A AU 24351/99A AU 2435199 A AU2435199 A AU 2435199A AU 2435199 A AU2435199 A AU 2435199A
Authority
AU
Australia
Prior art keywords
transferase inhibitors
farnesyl transferase
farnesyl
inhibitors
transferase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU24351/99A
Other languages
English (en)
Inventor
David John Drake
James Michael Wardleworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
AstraZeneca UK Ltd
Original Assignee
Zeneca Pharma SA
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Pharma SA, Zeneca Ltd filed Critical Zeneca Pharma SA
Publication of AU2435199A publication Critical patent/AU2435199A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU24351/99A 1998-02-10 1999-02-04 Farnesyl transferase inhibitors Abandoned AU2435199A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98400294 1998-02-10
EP98400294 1998-02-10
PCT/GB1999/000369 WO1999041235A1 (fr) 1998-02-10 1999-02-04 Inhibiteurs de la farnesyle transferase

Publications (1)

Publication Number Publication Date
AU2435199A true AU2435199A (en) 1999-08-30

Family

ID=8235269

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24351/99A Abandoned AU2435199A (en) 1998-02-10 1999-02-04 Farnesyl transferase inhibitors

Country Status (5)

Country Link
EP (1) EP1054865A1 (fr)
JP (1) JP2002503650A (fr)
AU (1) AU2435199A (fr)
WO (1) WO1999041235A1 (fr)
ZA (1) ZA991032B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5772698A (en) * 1997-01-29 1998-08-18 Zeneca Limited Inhibitors of farnesyl protein transferase
WO2001014314A1 (fr) * 1999-08-20 2001-03-01 Nippon Kayaku Kabushiki Kaisha Derives de benzene a substituants aromatiques et procedes de preparation de ceux-ci
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
AU784813B2 (en) 2000-01-17 2006-06-29 Bayer Aktiengesellschaft Substituted aryl ketones
US6271418B1 (en) 2000-02-22 2001-08-07 Nippon Kayaku Co., Ltd. Process for preparing (hetero) aromatic substituted benzene derivatives
EP1680109A4 (fr) 2003-10-07 2009-05-06 Renovis Inc Derives d'amide utilises comme ligands du canal ionique et compositions pharmaceutiques et methodes d'utilisation de ces derives
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
JP2011500783A (ja) * 2007-10-22 2011-01-06 オーキッド リサーチ ラボラトリーズ リミテッド ヒストンデアセチラーゼ阻害剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2155448A1 (fr) * 1994-08-11 1996-02-12 Katerina Leftheris Inhibiteurs de la farnesyl-proteine-transferase
GB9515975D0 (en) * 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
JP2002503650A (ja) 2002-02-05
EP1054865A1 (fr) 2000-11-29
WO1999041235A1 (fr) 1999-08-19
ZA991032B (en) 1999-10-27

Similar Documents

Publication Publication Date Title
AU6622396A (en) 4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors
PL337697A1 (en) Farnesil-proteinous transferase inhibitors
HU9602516D0 (en) Isoprenyl transferase inhibitors
AU5772698A (en) Inhibitors of farnesyl protein transferase
AU1844497A (en) Inhibitors of farnesyl-protein transferase
AU2253097A (en) Inhibitors of farnesyl-protein transferase
AU2430197A (en) Inhibitors of farnesyl-protein transferase
IL143409A0 (en) Farnesyl protein transferase inhibitors
AU2555997A (en) Inhibitors of farnesyl-protein transferase
AU2552497A (en) Inhibitors of farnesyl-protein transferase
AU2001252147A1 (en) Farnesyl protein transferase inhibitor combinations
AU1851697A (en) Inhibitors of farnesyl-protein transferase
AU2477400A (en) Inhibitors of prenyl-protein transferase
AU4020897A (en) 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
AU2432597A (en) Inhibitors of farnesyl-protein transferase
AU2432697A (en) Inhibitors of farnesyl-protein transferase
AU2430397A (en) Inhibitors of farnesyl-protein transferase
AU4685799A (en) Telomerase inhibitors
AU2554897A (en) Inhibitors of farnesyl-protein transferase
AU2435199A (en) Farnesyl transferase inhibitors
AU8253398A (en) Benzo(5,6)cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors
HUP0202152A2 (en) Tricyclyc farnesyl protein transferase inhibitors
EP1056450A4 (fr) Inhibiteurs de farnesyl proteine transferase
PL355887A1 (en) Farnesyl transferase inhibitors
AU6678398A (en) Inhibitors of isoprenyl transferase

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase