AU2383984A - Substituted pyrrolidine derivatives (lactam peptides) - Google Patents

Substituted pyrrolidine derivatives (lactam peptides)

Info

Publication number
AU2383984A
AU2383984A AU23839/84A AU2383984A AU2383984A AU 2383984 A AU2383984 A AU 2383984A AU 23839/84 A AU23839/84 A AU 23839/84A AU 2383984 A AU2383984 A AU 2383984A AU 2383984 A AU2383984 A AU 2383984A
Authority
AU
Australia
Prior art keywords
pyrrolidine derivatives
substituted pyrrolidine
lactam peptides
lactam
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU23839/84A
Other languages
English (en)
Inventor
William Bencze
Bruno Kamber
Angelo Storni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU2383984A publication Critical patent/AU2383984A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU23839/84A 1983-01-27 1984-01-26 Substituted pyrrolidine derivatives (lactam peptides) Abandoned AU2383984A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH454/83 1983-01-27
CH45483 1983-01-27

Publications (1)

Publication Number Publication Date
AU2383984A true AU2383984A (en) 1984-08-02

Family

ID=4187392

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23839/84A Abandoned AU2383984A (en) 1983-01-27 1984-01-26 Substituted pyrrolidine derivatives (lactam peptides)

Country Status (12)

Country Link
EP (1) EP0115473A3 (enrdf_load_stackoverflow)
JP (1) JPS59141544A (enrdf_load_stackoverflow)
KR (1) KR840007570A (enrdf_load_stackoverflow)
AU (1) AU2383984A (enrdf_load_stackoverflow)
DD (1) DD215539A5 (enrdf_load_stackoverflow)
DK (1) DK35984A (enrdf_load_stackoverflow)
FI (1) FI840261A7 (enrdf_load_stackoverflow)
GR (1) GR81747B (enrdf_load_stackoverflow)
IL (1) IL70791A0 (enrdf_load_stackoverflow)
NO (1) NO840311L (enrdf_load_stackoverflow)
PT (1) PT78008B (enrdf_load_stackoverflow)
ZA (1) ZA84595B (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190378B (it) * 1985-06-21 1988-02-16 Isf Spa Derivati pirrolidonici
JPH03500534A (ja) * 1988-04-22 1991-02-07 ２　モスコフスキ　ゴスダルストベンニ　メディツィンスキ　インスティテュト　イメニ　エヌー．イー．ピロゴバ ラクタム‐１‐酢酸カルボアルコキシメチルエステル及びその製造方法
JP2997488B2 (ja) * 1989-12-25 2000-01-11 興研株式会社 腫瘍細胞増殖抑制剤
JP2024538670A (ja) * 2021-09-30 2024-10-23 プロティニ ビー．ブイ． プロテアーゼ阻害剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT360980B (de) * 1976-01-14 1981-02-10 Pliva Pharm & Chem Works Verfahren zur herstellung von n-alkylamiden des 2-oxo-1-pyrrolidins
GB1539817A (en) * 1976-10-22 1979-02-07 Ucb Sa N-substituted lactams
US4254107A (en) * 1979-11-27 1981-03-03 Merck & Co., Inc. Long-lasting agonists of enkephalin

Also Published As

Publication number Publication date
EP0115473A3 (de) 1987-01-21
IL70791A0 (en) 1984-04-30
FI840261A7 (fi) 1984-07-28
GR81747B (enrdf_load_stackoverflow) 1984-12-12
DD215539A5 (de) 1984-11-14
DK35984D0 (da) 1984-01-26
KR840007570A (ko) 1984-12-08
ZA84595B (en) 1984-11-28
EP0115473A2 (de) 1984-08-08
DK35984A (da) 1984-07-28
NO840311L (no) 1984-07-30
FI840261A0 (fi) 1984-01-23
PT78008A (en) 1984-02-01
PT78008B (en) 1986-06-18
JPS59141544A (ja) 1984-08-14

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