AU2165492A - Method of extracting sennosides a, b and a1 - Google Patents

Method of extracting sennosides a, b and a1

Info

Publication number
AU2165492A
AU2165492A AU21654/92A AU2165492A AU2165492A AU 2165492 A AU2165492 A AU 2165492A AU 21654/92 A AU21654/92 A AU 21654/92A AU 2165492 A AU2165492 A AU 2165492A AU 2165492 A AU2165492 A AU 2165492A
Authority
AU
Australia
Prior art keywords
sennosides
extracting
anthrone
glucosides
concerns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU21654/92A
Other versions
AU662343B2 (en
Inventor
Alfons Carcasona
Wolf Grimminger
Pentti Hietala
Klaus Witthohn
Helga Zaeske
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Madaus AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus AG filed Critical Madaus AG
Publication of AU2165492A publication Critical patent/AU2165492A/en
Application granted granted Critical
Publication of AU662343B2 publication Critical patent/AU662343B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention concerns a method of extracting sennosides A, B and A1. The method comprises the following steps: a sennoside mixture is reduced to the corresponding anthrone-8-glucosides, the aloe-emodin components are removed by liquid-liquid separation of the anthrone-8-glucosides, and the rheine-9-anthrone-8-glucoside obtained after the separation step is oxidized again to sennosides A, B and A1. The invention also concerns sennosides A, B and A1 obtained by this method and pharmaceutical agents containing them.
AU21654/92A 1991-06-25 1992-06-24 Method of extracting sennosides A, B and A1 Ceased AU662343B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4120991A DE4120991A1 (en) 1991-06-25 1991-06-25 PROCESS FOR OBTAINING SENNOSIDES A, B AND A1
DE4120991 1991-06-25
PCT/EP1992/001428 WO1993000350A1 (en) 1991-06-25 1992-06-24 METHOD OF EXTRACTING SENNOSIDES A, B and A1

Publications (2)

Publication Number Publication Date
AU2165492A true AU2165492A (en) 1993-01-25
AU662343B2 AU662343B2 (en) 1995-08-31

Family

ID=6434719

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21654/92A Ceased AU662343B2 (en) 1991-06-25 1992-06-24 Method of extracting sennosides A, B and A1

Country Status (18)

Country Link
EP (1) EP0544886B1 (en)
JP (1) JP2705733B2 (en)
AT (1) ATE157984T1 (en)
AU (1) AU662343B2 (en)
CA (1) CA2090340C (en)
CZ (1) CZ281687B6 (en)
DE (2) DE4120991A1 (en)
DK (1) DK0544886T3 (en)
ES (1) ES2110000T3 (en)
FI (1) FI104902B (en)
GR (1) GR3024842T3 (en)
HU (1) HU210198B (en)
IE (1) IE922048A1 (en)
PL (1) PL173870B1 (en)
RU (1) RU2104281C1 (en)
SK (1) SK23493A3 (en)
WO (1) WO1993000350A1 (en)
ZA (1) ZA924646B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI96692C (en) * 1993-12-17 1996-08-12 Leiras Oy Process for producing Sennocide A and B
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US5560913A (en) * 1995-01-27 1996-10-01 The Procter & Gamble Company Pharmaceutical compositions
ITRM20130294A1 (en) * 2013-05-16 2014-11-17 Aboca Spa Societa Agricola SENNA EXTRACTS AND THEIR USES
CN113624853A (en) * 2020-05-07 2021-11-09 厦门泓益检测有限公司 Method for simultaneously detecting cathartic components in weight-reducing product based on UPLC-MS/MS
CN117224419B (en) * 2023-11-14 2024-01-30 山东第一医科大学(山东省医学科学院) Application of sennoside C in preparing skin whitening and spot-fading skin care product and related product

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB555450A (en) * 1941-05-13 1943-08-24 Sandoz Ltd Process for the preparation of active glucosides of senna
GB832017A (en) * 1957-10-02 1960-04-06 Westminster Lab Ltd Senna preparations
DE1617667B1 (en) * 1966-09-08 1970-09-03 Nattermann A & Cie Process for the production of a sennosid-rich active ingredient concentrate from sennessee pods
JPS54149813U (en) * 1978-04-10 1979-10-18
DE3200131A1 (en) * 1982-01-05 1983-07-14 Madaus & Co Dr "METHOD FOR OBTAINING LAXATIVE COMPOUNDS FROM SENNADROGE"
FR2594337A1 (en) * 1986-02-17 1987-08-21 Oppag Sa Sennoside-based composition and process for preparing this composition

Also Published As

Publication number Publication date
DE4120991A1 (en) 1993-01-07
CZ37093A3 (en) 1996-12-11
HU210198B (en) 1995-02-28
EP0544886A1 (en) 1993-06-09
CZ281687B6 (en) 1996-12-11
FI104902B (en) 2000-04-28
HU9300506D0 (en) 1993-05-28
DK0544886T3 (en) 1997-10-13
DE59208889D1 (en) 1997-10-16
FI930790A (en) 1993-02-23
ATE157984T1 (en) 1997-09-15
HUT64007A (en) 1993-11-29
JP2705733B2 (en) 1998-01-28
IE922048A1 (en) 1992-12-30
AU662343B2 (en) 1995-08-31
ZA924646B (en) 1993-03-31
PL173870B1 (en) 1998-05-29
EP0544886B1 (en) 1997-09-10
CA2090340C (en) 1998-08-18
GR3024842T3 (en) 1998-01-30
RU2104281C1 (en) 1998-02-10
FI930790A0 (en) 1993-02-23
JPH06502191A (en) 1994-03-10
ES2110000T3 (en) 1998-02-01
PL298140A1 (en) 1993-11-02
CA2090340A1 (en) 1992-12-26
WO1993000350A1 (en) 1993-01-07
SK23493A3 (en) 1993-07-07

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired