AU2050483A - 1,1,2-triphenyl-but-i-ene derivatives - Google Patents

1,1,2-triphenyl-but-i-ene derivatives

Info

Publication number
AU2050483A
AU2050483A AU20504/83A AU2050483A AU2050483A AU 2050483 A AU2050483 A AU 2050483A AU 20504/83 A AU20504/83 A AU 20504/83A AU 2050483 A AU2050483 A AU 2050483A AU 2050483 A AU2050483 A AU 2050483A
Authority
AU
Australia
Prior art keywords
triphenyl
group
ene derivatives
atoms
corresponds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU20504/83A
Other versions
AU558994B2 (en
Inventor
Helmut Grill
Roland Loser
Helmut Schickaneder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of AU2050483A publication Critical patent/AU2050483A/en
Application granted granted Critical
Publication of AU558994B2 publication Critical patent/AU558994B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Epoxy Compounds (AREA)

Abstract

1. 1,1,2-triphenyl-but-1-en-derivatives represented by general formula (1), the configuration of which corresponds to E form see diagramm : EP0107208,P11,F2 in which R in position 3' or 4' is a methyl group, methoxy group, hydroxy group or a halogen atom and R**1 is an alkyl group with 1 to 4 C atoms, and the therapeutically acceptable salts thereof.
AU20504/83A 1982-10-26 1983-10-24 1,1,2-triphenyl-but-i-ene derivatives Ceased AU558994B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3239610 1982-10-26
DE19823239610 DE3239610A1 (en) 1982-10-26 1982-10-26 NEW 1,1,2-TRIPHENYL-BUT-L-EN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
AU2050483A true AU2050483A (en) 1984-05-03
AU558994B2 AU558994B2 (en) 1987-02-19

Family

ID=6176636

Family Applications (1)

Application Number Title Priority Date Filing Date
AU20504/83A Ceased AU558994B2 (en) 1982-10-26 1983-10-24 1,1,2-triphenyl-but-i-ene derivatives

Country Status (7)

Country Link
EP (1) EP0107208B1 (en)
JP (1) JPS59104349A (en)
AT (1) ATE17570T1 (en)
AU (1) AU558994B2 (en)
CA (1) CA1220787A (en)
DE (2) DE3239610A1 (en)
IE (1) IE56152B1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3781546D1 (en) * 1987-04-21 1992-10-08 Heumann Pharma Gmbh & Co STABLE SOLVENT ADDUCTS OF Z-1- (P-BETA-DIMETHYLAMINO-ETHOXYPHENYL) -1- (P-HYDROXYPHENYL) -2-PHENYLBUT-1-EN.
JP4572407B2 (en) * 2005-03-04 2010-11-04 学校法人東京理科大学 Method for producing droloxifene
CN106810460A (en) * 2016-12-30 2017-06-09 苏州诚和医药化学有限公司 A kind of preparation method of 4 [2 (dimethylamino) ethyoxyl] benzylamines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1099093A (en) * 1965-09-03 1968-01-17 Ici Ltd Alkene derivatives
EP0002097B1 (en) * 1977-08-22 1981-08-05 Imperial Chemical Industries Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
US4206234A (en) * 1977-08-22 1980-06-03 Imperial Chemical Industries Limited Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
DE2964736D1 (en) * 1978-11-07 1983-03-17 Ici Plc 1-acyloxyphenyl-1,2-diphenylalkene derivatives, processes for their manufacture and a pharmaceutical composition containing these derivatives
DE3046719C2 (en) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-ene derivatives, processes for their preparation and pharmaceuticals

Also Published As

Publication number Publication date
JPS6241704B2 (en) 1987-09-04
DE3361936D1 (en) 1986-03-06
CA1220787A (en) 1987-04-21
EP0107208B1 (en) 1986-01-22
AU558994B2 (en) 1987-02-19
IE832495L (en) 1984-04-26
ATE17570T1 (en) 1986-02-15
JPS59104349A (en) 1984-06-16
DE3239610A1 (en) 1984-04-26
IE56152B1 (en) 1991-05-08
EP0107208A1 (en) 1984-05-02

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