AU2023318846A1 - Multi-specific polypeptide complexes - Google Patents

Multi-specific polypeptide complexes Download PDF

Info

Publication number
AU2023318846A1
AU2023318846A1 AU2023318846A AU2023318846A AU2023318846A1 AU 2023318846 A1 AU2023318846 A1 AU 2023318846A1 AU 2023318846 A AU2023318846 A AU 2023318846A AU 2023318846 A AU2023318846 A AU 2023318846A AU 2023318846 A1 AU2023318846 A1 AU 2023318846A1
Authority
AU
Australia
Prior art keywords
pair
polypeptide
domain
amino acid
psr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2023318846A
Other languages
English (en)
Inventor
Gong WANG
Jie Zhang
Zhenhao ZHOU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Kaijin Biotechnology Ltd
Chimagen Biosciences Ltd
Original Assignee
Shanghai Kaijin Biotechnology Ltd
Chimagen Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Kaijin Biotechnology Ltd, Chimagen Biosciences Ltd filed Critical Shanghai Kaijin Biotechnology Ltd
Publication of AU2023318846A1 publication Critical patent/AU2023318846A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2023318846A 2022-08-05 2023-02-07 Multi-specific polypeptide complexes Pending AU2023318846A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2022/110697 2022-08-05
CN2022110697 2022-08-05
PCT/CN2023/074836 WO2024027120A1 (en) 2022-08-05 2023-02-07 Multi-specific polypeptide complexes

Publications (1)

Publication Number Publication Date
AU2023318846A1 true AU2023318846A1 (en) 2025-02-27

Family

ID=89848477

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2023318846A Pending AU2023318846A1 (en) 2022-08-05 2023-02-07 Multi-specific polypeptide complexes

Country Status (6)

Country Link
EP (1) EP4565620A1 (https=)
JP (1) JP2025528101A (https=)
CN (1) CN119998329A (https=)
AU (1) AU2023318846A1 (https=)
CA (1) CA3263920A1 (https=)
WO (1) WO2024027120A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3177643B1 (en) * 2014-08-04 2019-05-08 F.Hoffmann-La Roche Ag Bispecific t cell activating antigen binding molecules
WO2017055392A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Anti-cd3xcd44v6 bispecific t cell activating antigen binding molecules
WO2017055314A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific anti-cd19xcd3 t cell activating antigen binding molecules
KR102692708B1 (ko) * 2016-12-20 2024-08-07 에프. 호프만-라 로슈 아게 항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법
CR20210330A (es) * 2018-12-21 2021-07-20 Hoffmann La Roche ANTICUERPOS QUE SE UNEN A CD3 (Divisional 2021-0325)
CA3124688A1 (en) * 2018-12-31 2020-07-09 Merus N.V. Truncated multivalent multimers
WO2020156405A1 (en) * 2019-01-28 2020-08-06 Wuxi Biologics (Shanghai) Co. Ltd. Novel bispecific cd3/cd20 polypeptide complexes
IL302412A (en) * 2020-11-06 2023-06-01 Novartis Ag Anti-CD19 and B-cell targeting agent combination therapy for the treatment of B-cell malignancies

Also Published As

Publication number Publication date
CN119998329A (zh) 2025-05-13
JP2025528101A (ja) 2025-08-26
WO2024027120A1 (en) 2024-02-08
EP4565620A1 (en) 2025-06-11
CA3263920A1 (en) 2024-02-08

Similar Documents

Publication Publication Date Title
JP7579795B2 (ja) ＮＫｐ３０に結合する抗体分子およびその使用
JP2023061969A (ja) Ｓｉｒｐ－アルファドメインまたはそのバリアントを有する構築物
TWI874613B (zh) 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法
WO2019057099A1 (en) NOVEL ANTI-CD3EPSILON ANTIBODIES
CN106397598A (zh) 多价多特异性抗体及免疫杂合蛋白的表达和制备方法
CN116917316A (zh) 与NKp30结合的抗体分子及其用途
WO2020192709A1 (en) Novel bispecific polypeptide complexes
US20240182576A1 (en) Heterodimeric antibodies and antigen-binding fragment thereof
JP2023547661A (ja) Ｃｄ３に結合するポリペプチド構築物
JP2023548345A (ja) クリッピング率の低減した抗原結合ドメイン
CN114340668A (zh) 结合于cd38和cd3的异源二聚抗体
WO2024027120A1 (en) Multi-specific polypeptide complexes
WO2024149381A1 (en) Multi-specific polypeptide complexes
WO2025026282A1 (en) Modified type e multi-specific antibodies
WO2024027828A1 (en) Multi-specific antibodies targeting a dimerizable tumor antigen and an immunostimulatory antigen
WO2022156687A1 (en) Polypeptide complexes with improved stability and expression
WO2025092987A9 (zh) 基于Fc区的异二聚体分子及其用途
WO2024131731A1 (zh) "κ/λ"Fab-Fab串联多特异性结合蛋白及其制备和应用