AU2022335128A1 - Human transferrin receptor-binding antibody-peptide conjugate - Google Patents

Human transferrin receptor-binding antibody-peptide conjugate Download PDF

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Publication number
AU2022335128A1
AU2022335128A1 AU2022335128A AU2022335128A AU2022335128A1 AU 2022335128 A1 AU2022335128 A1 AU 2022335128A1 AU 2022335128 A AU2022335128 A AU 2022335128A AU 2022335128 A AU2022335128 A AU 2022335128A AU 2022335128 A1 AU2022335128 A1 AU 2022335128A1
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AU
Australia
Prior art keywords
amino acid
peptide
seq
antibody
residue
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Pending
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AU2022335128A
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English (en)
Inventor
Saki FUJIYAMA
Hidehiko Hashimoto
Shinnosuke INABA
Masaki Ohuchi
Naoki Sawai
Kenichi Takahashi
Eiji Yoden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Peptidream Inc
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JCR Pharmaceuticals Co Ltd
Peptidream Inc
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Application filed by JCR Pharmaceuticals Co Ltd, Peptidream Inc filed Critical JCR Pharmaceuticals Co Ltd
Publication of AU2022335128A1 publication Critical patent/AU2022335128A1/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
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    • C07K—PEPTIDES
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    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Psychology (AREA)
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  • Cardiology (AREA)
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  • Virology (AREA)
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AU2022335128A 2021-08-24 2022-08-24 Human transferrin receptor-binding antibody-peptide conjugate Pending AU2022335128A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021136682 2021-08-24
JP2021-136682 2021-08-24
PCT/JP2022/031933 WO2023027125A1 (ja) 2021-08-24 2022-08-24 ヒトトランスフェリンレセプター結合抗体－ペプチドコンジュゲート

Publications (1)

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AU2022335128A1 true AU2022335128A1 (en) 2024-03-07

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AU2022335128A Pending AU2022335128A1 (en) 2021-08-24 2022-08-24 Human transferrin receptor-binding antibody-peptide conjugate

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US (1) US20240366775A1 (https=)
EP (1) EP4393959A1 (https=)
JP (1) JPWO2023027125A1 (https=)
CN (1) CN118201966A (https=)
AU (1) AU2022335128A1 (https=)
CA (1) CA3229962A1 (https=)
IL (1) IL311025A (https=)
WO (1) WO2023027125A1 (https=)

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WO2025140565A1 (zh) * 2023-12-27 2025-07-03 苏州瑞博生物技术股份有限公司 一种载体肽、含有该载体肽的缀合物、组合物及制备方法和用途

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WO2021054370A1 (ja) 2019-09-18 2021-03-25 国立大学法人東京医科歯科大学 核酸複合体
WO2021167107A1 (ja) 2020-02-22 2021-08-26 Ｊｃｒファーマ株式会社 ヒトトランスフェリンレセプター結合ペプチド

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