AU2022270089A1 - Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use - Google Patents

Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use Download PDF

Info

Publication number
AU2022270089A1
AU2022270089A1 AU2022270089A AU2022270089A AU2022270089A1 AU 2022270089 A1 AU2022270089 A1 AU 2022270089A1 AU 2022270089 A AU2022270089 A AU 2022270089A AU 2022270089 A AU2022270089 A AU 2022270089A AU 2022270089 A1 AU2022270089 A1 AU 2022270089A1
Authority
AU
Australia
Prior art keywords
certain embodiments
harness
formula
compound
stereoisomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022270089A
Other languages
English (en)
Inventor
Daisuke Kato
Joel Mcintosh
Jeffrey Mihalic
Ge Peng
Eric Wegrzyniak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nurix Therapeutics Inc
Original Assignee
Nurix Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nurix Therapeutics Inc filed Critical Nurix Therapeutics Inc
Publication of AU2022270089A1 publication Critical patent/AU2022270089A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2022270089A 2021-05-03 2022-05-03 Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use Pending AU2022270089A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163183619P 2021-05-03 2021-05-03
US63/183,619 2021-05-03
US202263304497P 2022-01-28 2022-01-28
US63/304,497 2022-01-28
PCT/US2022/027512 WO2022235698A1 (en) 2021-05-03 2022-05-03 Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use

Publications (1)

Publication Number Publication Date
AU2022270089A1 true AU2022270089A1 (en) 2023-11-16

Family

ID=81750420

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022270089A Pending AU2022270089A1 (en) 2021-05-03 2022-05-03 Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use

Country Status (6)

Country Link
US (1) US20230158151A1 (ja)
EP (1) EP4334302A1 (ja)
JP (1) JP2024517859A (ja)
AU (1) AU2022270089A1 (ja)
CA (1) CA3217892A1 (ja)
WO (1) WO2022235698A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3226118A1 (en) 2021-08-18 2023-02-23 Nurix Therapeutics, Inc. Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof
WO2023143249A1 (zh) * 2022-01-28 2023-08-03 上海齐鲁制药研究中心有限公司 靶向malt1的蛋白降解化合物
WO2023220640A1 (en) * 2022-05-10 2023-11-16 Biotheryx, Inc. Cdk protein degraders, pharmaceutical compositions, and therapeutic applications
CN116751186A (zh) * 2022-12-23 2023-09-15 南京知和医药科技有限公司 一种雌激素受体调节剂的制备及其用途
CN116283918A (zh) * 2023-03-16 2023-06-23 泰比棣医药科技(石家庄)有限公司 一种降解受体酪氨酸激酶的双功能化合物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299070B2 (en) * 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
LT3689868T (lt) * 2016-12-01 2023-12-27 Arvinas Operations, Inc. Tetrahidronaftaleno ir tetrahidroizochinolino dariniai kaip estrogenų receptorių destruktoriai
JP2022529339A (ja) * 2019-04-18 2022-06-21 ヒノバ ファーマシューティカルズ インコーポレイテッド アンドロゲン受容体を標的に分解する二官能性キメラ複素環式化合物及びその使用
US20220281876A1 (en) * 2019-07-26 2022-09-08 Beigene, Ltd. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
CN114521196A (zh) * 2019-09-16 2022-05-20 诺华股份有限公司 双官能团降解剂及其使用方法
JP2022552006A (ja) * 2019-10-17 2022-12-14 アルヴィナス・オペレーションズ・インコーポレイテッド Ｂｃｌ６標的化部分に連結されたｅ３ユビキチンリガーゼ結合部分を含有する二官能性分子

Also Published As

Publication number Publication date
EP4334302A1 (en) 2024-03-13
CA3217892A1 (en) 2022-11-10
JP2024517859A (ja) 2024-04-23
WO2022235698A1 (en) 2022-11-10
US20230158151A1 (en) 2023-05-25

Similar Documents

Publication Publication Date Title
US11820781B2 (en) Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
AU2019360928B2 (en) Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
AU2022270089A1 (en) Compounds for inhibiting or degrading target proteins, compositions, comprising the same, methods of their making, and methods of their use
US20230024442A1 (en) Bifunctional compounds for grading btk via ubiquitin proteosome pathway
EP3924350A1 (en) Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
KR20240039001A (ko) 향상된 imid 활성으로 btk를 분해하기 위한 이작용성 화합물
CA3225367A1 (en) Bifunctional compounds for degrading btk with diminished imid activity
AU2022269594A1 (en) Compounds for inhibiting or degrading itk, compositions, comprising the same methods of their making and methods of their use
CN117916231A (zh) 用于抑制或降解靶蛋白的化合物、包含其的组合物、其制备方法及其使用方法
WO2023069514A2 (en) Bifunctional compounds for degrading itk via ubiquitin proteosome pathway
BR122023025072A2 (pt) Usos de compostos bifuncionais para degradar btk por meio da via da ubiquitina-proteossoma