AU2022223203A1 - Methods of producing haemogenic endothelial cells from pluripotent stem cells - Google Patents

Methods of producing haemogenic endothelial cells from pluripotent stem cells Download PDF

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AU2022223203A1
AU2022223203A1 AU2022223203A AU2022223203A AU2022223203A1 AU 2022223203 A1 AU2022223203 A1 AU 2022223203A1 AU 2022223203 A AU2022223203 A AU 2022223203A AU 2022223203 A AU2022223203 A AU 2022223203A AU 2022223203 A1 AU2022223203 A1 AU 2022223203A1
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cells
induction medium
mesoderm
population
hecs
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AU2022223203A
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Eva GARCIA-ALEGRIA
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Adaptimmune Ltd
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Adaptimmune Ltd
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
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AU2022223203A 2021-02-18 2022-02-17 Methods of producing haemogenic endothelial cells from pluripotent stem cells Abandoned AU2022223203A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2102297.5 2021-02-18
GBGB2102297.5A GB202102297D0 (en) 2021-02-18 2021-02-18 Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
PCT/EP2022/053985 WO2022175401A1 (en) 2021-02-18 2022-02-17 Methods of producing haemogenic endothelial cells from pluripotent stem cells

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AU2022223203A1 true AU2022223203A1 (en) 2023-09-07

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AU2022223203A Abandoned AU2022223203A1 (en) 2021-02-18 2022-02-17 Methods of producing haemogenic endothelial cells from pluripotent stem cells

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US (1) US20240124841A1 (https=)
EP (1) EP4294911A1 (https=)
JP (1) JP2024507472A (https=)
CN (1) CN116917465A (https=)
AU (1) AU2022223203A1 (https=)
CA (1) CA3208416A1 (https=)
GB (1) GB202102297D0 (https=)
IL (1) IL305018A (https=)
WO (1) WO2022175401A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201911958D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of t cell production
GB202205572D0 (en) 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
CN115247152B (zh) * 2022-09-21 2022-12-27 呈诺再生医学科技(北京)有限公司 制备造血干细胞或造血干祖细胞的方法及培养长期再生造血干细胞的方法
CN118360247A (zh) * 2023-01-19 2024-07-19 中国科学院动物研究所 一种iSCLP细胞及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5777115B2 (ja) * 2010-03-18 2015-09-09 国立大学法人京都大学 多能性幹細胞から中胚葉細胞への分化誘導法
JP6677631B2 (ja) * 2013-03-13 2020-04-08 ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 定義された条件下におけるヒト多能性幹細胞の造血内皮分化のための方法及び材料
CA2925774A1 (en) * 2013-10-01 2015-04-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human ipsc-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings
WO2015199127A1 (ja) * 2014-06-24 2015-12-30 国立大学法人京都大学 中胚葉細胞および造血細胞の製造方法
AU2016211671B2 (en) * 2015-01-26 2022-05-26 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CA3003152A1 (en) * 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
SG11202006731VA (en) * 2018-01-18 2020-08-28 Agency Science Tech & Res Method for differentiation of human pluripotent stem cell lines in suspension culture
IL282563B2 (en) * 2018-10-24 2025-05-01 Hebecell Corp Methods and systems for producing lineage cells involved in the formation of blood cells
AU2020333918A1 (en) * 2019-08-20 2022-03-24 Adaptimmune Limited Culture medium for haematopoietic induction
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells

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IL305018A (en) 2023-10-01
GB202102297D0 (en) 2021-04-07
JP2024507472A (ja) 2024-02-20
EP4294911A1 (en) 2023-12-27
WO2022175401A1 (en) 2022-08-25
CN116917465A (zh) 2023-10-20
US20240124841A1 (en) 2024-04-18
CA3208416A1 (en) 2022-08-25

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