AU2021308344B2 - Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same - Google Patents

Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same Download PDF

Info

Publication number
AU2021308344B2
AU2021308344B2 AU2021308344A AU2021308344A AU2021308344B2 AU 2021308344 B2 AU2021308344 B2 AU 2021308344B2 AU 2021308344 A AU2021308344 A AU 2021308344A AU 2021308344 A AU2021308344 A AU 2021308344A AU 2021308344 B2 AU2021308344 B2 AU 2021308344B2
Authority
AU
Australia
Prior art keywords
mmol
methyl
compound
triazol
difluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2021308344A
Other languages
English (en)
Other versions
AU2021308344A1 (en
Inventor
Younghue HAN
Jin Kyung IN
Bomi JEON
Hyunjin Michael KIM
Yi Hyun Kim
Jae Kwang Lee
Jaeki Min
Hong Ju Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chong Kun Dang Corp
Original Assignee
Chong Kun Dang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chong Kun Dang Corp filed Critical Chong Kun Dang Corp
Publication of AU2021308344A1 publication Critical patent/AU2021308344A1/en
Application granted granted Critical
Publication of AU2021308344B2 publication Critical patent/AU2021308344B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2021308344A 2020-07-14 2021-07-13 Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same Active AU2021308344B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20200087126 2020-07-14
KR10-2020-0087126 2020-07-14
PCT/IB2021/056282 WO2022013728A1 (fr) 2020-07-14 2021-07-13 Nouveaux composés utilisés en tant qu'inhibiteurs de l'histone désacétylase 6 et composition pharmaceutique les comprenant

Publications (2)

Publication Number Publication Date
AU2021308344A1 AU2021308344A1 (en) 2023-03-09
AU2021308344B2 true AU2021308344B2 (en) 2024-03-14

Family

ID=79555104

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021308344A Active AU2021308344B2 (en) 2020-07-14 2021-07-13 Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same

Country Status (11)

Country Link
US (1) US20230257372A1 (fr)
EP (1) EP4185586A1 (fr)
JP (1) JP2023533783A (fr)
KR (1) KR102504830B1 (fr)
CN (1) CN116133658A (fr)
AU (1) AU2021308344B2 (fr)
BR (1) BR112023000560A2 (fr)
CA (1) CA3185923A1 (fr)
MX (1) MX2023000625A (fr)
TW (1) TWI794880B (fr)
WO (1) WO2022013728A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018165520A1 (fr) 2017-03-10 2018-09-13 Vps-3, Inc. Composés inhibiteurs de métalloenzymes
WO2022029041A1 (fr) * 2020-08-07 2022-02-10 Italfarmaco S.P.A. Dérivés de 2-(4-((5-(benzo[b]thiophén-3-yl)-1h-tétrazol-1-yl)méthyl)phényl)-5-(difluorométhyl)-1,3,4-oxadiazole et composés similaires en tant qu'inhibiteurs sélectifs de l'histone désacétylase 6 (hdac6) pour une utilisation dans le traitement, par exemple, de la neuropathie périphérique
WO2024013690A1 (fr) * 2022-07-15 2024-01-18 Chong Kun Dang Pharmaceutical Corp. Composés de 1,3,4-oxadiazole triazole utilisés en tant qu'inhibiteurs de l'histone désacétylase 6, et composition pharmaceutique les comprenant
WO2024017897A1 (fr) * 2022-07-19 2024-01-25 Italfarmaco S.P.A. Dérivés de 1,3,4-oxadiazole utilisés en tant qu'inhibiteurs sélectifs de l'histone désacétylase 6
WO2024033293A1 (fr) 2022-08-08 2024-02-15 Italfarmaco S.P.A. Hydrazides difluoro- et trifluoro-acétyle utilisés en tant qu'inhibiteurs sélectifs de hdac6

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2009119880A1 (fr) * 2008-03-26 2009-10-01 Takeda Pharmaceutical Company Limited Dérivés pyrazole substitués et leur utilisation
TWI511732B (zh) 2010-01-22 2015-12-11 Acetylon Pharmaceuticals Inc 作為蛋白質去乙醯酶抑制劑之反式醯胺化合物及其使用方法
WO2013066838A1 (fr) * 2011-10-31 2013-05-10 Glaxosmithkline Llc Composés et procédés
EP2822926A4 (fr) 2012-03-07 2015-11-04 H Lee Moffitt Cancer Ct & Res Inhibiteurs sélectifs d'histone désacétylase 6
PT3328844T (pt) * 2015-07-27 2020-03-04 Chong Kun Dang Pharmaceutical Corp Derivados de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e composição farmacêutica compreendendo os mesmos
WO2017222951A1 (fr) * 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 5-trifluorométhyl-oxadiazoles substitués en 3-aryle et hétéroaryle en tant qu'inhibiteurs de l'histone désacétylase 6 (hdac6)
CN113473860A (zh) * 2018-12-21 2021-10-01 拜耳公司 作为新的抗真菌剂的1，3，4-噁二唑及其衍生物
US20220213084A1 (en) * 2019-04-17 2022-07-07 Quimatryx, S.L. 1,3,4-oxadiazole derivatives as histone deacetylase inhibitors

Also Published As

Publication number Publication date
EP4185586A1 (fr) 2023-05-31
JP2023533783A (ja) 2023-08-04
US20230257372A1 (en) 2023-08-17
AU2021308344A1 (en) 2023-03-09
BR112023000560A2 (pt) 2023-01-31
CN116133658A (zh) 2023-05-16
KR102504830B1 (ko) 2023-03-02
TW202208351A (zh) 2022-03-01
KR20220008787A (ko) 2022-01-21
TWI794880B (zh) 2023-03-01
CA3185923A1 (fr) 2022-01-20
MX2023000625A (es) 2023-02-22
WO2022013728A1 (fr) 2022-01-20

Similar Documents

Publication Publication Date Title
AU2021308344B2 (en) Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same
CN110352188B (zh) 氟代烯丙胺衍生物及其用途
EP2991982B1 (fr) Nouveaux composés pour inhibiteurs sélectifs d'histone désacétylases et composition pharmaceutique les comprenant
EP2800565B1 (fr) Composés de carbamate et leur préparation et utilisation
EP3634958B1 (fr) Agonistes du récepteur 2 du peptide formylé et agonistes du récepteur 1 du peptide formylé à base de cyclopropyle d'urée
US8623898B2 (en) Glycine transporter inhibiting substances
AU2021337217B2 (en) Novel compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same
JP7492597B2 (ja) Ｇｐｒ５２モジュレーター化合物
KR20180091876A (ko) 피페리디논 포르밀 펩티드 2 수용체 및 포르밀 펩티드 1 수용체 효능제
CN111484491B (zh) 取代吡啶并环化合物、其制备方法和用途
WO2012036278A1 (fr) Inhibiteur de transporteur de glycine
US20230092890A1 (en) 1, 3, 4-Oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
KR20200078591A (ko) 키나제 억제제로서의 아미노이미다조피리다진
JP2021500334A (ja) Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法
CN115991706A (zh) Pim激酶抑制剂
JP7428833B2 (ja) ヒストン脱アセチル化酵素６阻害剤としての１，３，４－オキサジアゾール誘導体化合物、およびそれを含む医薬組成物
JP2023516824A (ja) ヒストン脱アセチル化酵素６阻害剤としての１，３，４－オキサジアゾール誘導体化合物、およびそれを含む医薬組成物
AU2022253373B2 (en) 1,3,4-oxadiazole thiocarbonyl compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same
RU2817736C1 (ru) Новые соединения в качестве ингибитора гистондеацетилазы 6 и фармацевтическая композиция, содержащая их
US20230278995A1 (en) 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
RU2810081C1 (ru) Производные 1,3,4-оксадиазола в качестве ингибитора гистондеацетилазы 6 и содержащая их фармацевтическая композиция
WO2024079682A1 (fr) Composés de sulfoximine utilisés en tant qu'inhibiteur de l'histone désacétylase 6, et composition pharmaceutique les comprenant
KR20240035172A (ko) 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도
KR20240093844A (ko) Gpr39 단백질의 길항제