AU2021308208A1 - SARS-CoV-2 inhibitors - Google Patents

SARS-CoV-2 inhibitors Download PDF

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Publication number
AU2021308208A1
AU2021308208A1 AU2021308208A AU2021308208A AU2021308208A1 AU 2021308208 A1 AU2021308208 A1 AU 2021308208A1 AU 2021308208 A AU2021308208 A AU 2021308208A AU 2021308208 A AU2021308208 A AU 2021308208A AU 2021308208 A1 AU2021308208 A1 AU 2021308208A1
Authority
AU
Australia
Prior art keywords
amino acid
acid sequence
polypeptide
seq
nos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021308208A
Other languages
English (en)
Inventor
David Baker
John Bowen
Scott BOYKEN
Longxing CAO
Lauren Carter
James Brett CASE
Brian COVENTRY
Michael Diamond
Natasha EDMAN
Inna GORESHNIK
Andrew Hunt
Michael Christopher Jewett
Lisa KOZODOY
Lauren Miller
Cassandra Jean OGOHARA
Young-Jun Park
Rashmi RAVICHANDRAN
Lance Joseph STEWART
George Ueda
David VEESLER
Bastian VOGELI
Alexandra C. WALLS
Kejia WU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Northwestern University
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Northwestern University
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Northwestern University, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of AU2021308208A1 publication Critical patent/AU2021308208A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
  • Immunology (AREA)
AU2021308208A 2020-07-14 2021-05-25 SARS-CoV-2 inhibitors Pending AU2021308208A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063051474P 2020-07-14 2020-07-14
US63/051,474 2020-07-14
US202063067593P 2020-08-19 2020-08-19
US63/067,593 2020-08-19
PCT/US2021/034069 WO2022015418A1 (en) 2020-07-14 2021-05-25 Sars-cov-2 inhibitors

Publications (1)

Publication Number Publication Date
AU2021308208A1 true AU2021308208A1 (en) 2023-01-05

Family

ID=76808129

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021308208A Pending AU2021308208A1 (en) 2020-07-14 2021-05-25 SARS-CoV-2 inhibitors

Country Status (7)

Country Link
US (1) US20230250134A1 (https=)
EP (1) EP4182027A1 (https=)
JP (2) JP2023542453A (https=)
KR (1) KR20230038485A (https=)
CN (1) CN116209672A (https=)
AU (1) AU2021308208A1 (https=)
WO (1) WO2022015418A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202317599A (zh) * 2021-07-07 2023-05-01 國立大學法人東京醫科齒科大學 具有抗病毒活性之胜肽、包含該胜肽之抗病毒劑、該抗病毒劑之製造方法
KR20240177843A (ko) * 2023-06-20 2024-12-30 주식회사 엔큐라젠 SARS-CoV-2스파이크 단백질에 특이적으로 결합하는 펩타이드 및 이의 용도
WO2025101453A1 (en) * 2023-11-07 2025-05-15 University Of Washington De novo design of potent minibinder antagonists of il-6r, gp130, and il1-r1
WO2025221716A1 (en) * 2024-04-17 2025-10-23 University Of Washington Smart mhc: a de-novo designed platform for soluble expression of peptide-receptive class-i mhc in e. coli

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900033B2 (en) * 2001-06-04 2005-05-31 Human Genome Sciences, Inc. Methods and compositions for modulating ACE-2 activity
CA3178016A1 (en) * 2020-05-27 2021-12-02 University Of Washington Modular and generalizable biosensor platform based on de novo designed protein switches

Also Published As

Publication number Publication date
KR20230038485A (ko) 2023-03-20
JP2023542453A (ja) 2023-10-10
JP2025170319A (ja) 2025-11-18
US20230250134A1 (en) 2023-08-10
EP4182027A1 (en) 2023-05-24
WO2022015418A1 (en) 2022-01-20
CN116209672A (zh) 2023-06-02

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