AU2021225870A1 - Materials and methods for modulating an immune response - Google Patents

Materials and methods for modulating an immune response Download PDF

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Publication number
AU2021225870A1
AU2021225870A1 AU2021225870A AU2021225870A AU2021225870A1 AU 2021225870 A1 AU2021225870 A1 AU 2021225870A1 AU 2021225870 A AU2021225870 A AU 2021225870A AU 2021225870 A AU2021225870 A AU 2021225870A AU 2021225870 A1 AU2021225870 A1 AU 2021225870A1
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AU
Australia
Prior art keywords
amino acid
acid sequence
antibody
seq
cdr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2021225870A
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English (en)
Inventor
Rajkumar Ganesan
Iqbal S. Grewal
Sanjaya Singh
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Janssen Biotech Inc
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Janssen Biotech Inc
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Filing date
Publication date
Priority claimed from PCT/US2020/031749 external-priority patent/WO2020227457A1/en
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of AU2021225870A1 publication Critical patent/AU2021225870A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2021225870A 2020-02-27 2021-02-26 Materials and methods for modulating an immune response Abandoned AU2021225870A1 (en)

Applications Claiming Priority (91)

Application Number Priority Date Filing Date Title
US202062982669P 2020-02-27 2020-02-27
US202062982462P 2020-02-27 2020-02-27
US202062982664P 2020-02-27 2020-02-27
US202062982469P 2020-02-27 2020-02-27
US202062982374P 2020-02-27 2020-02-27
US202062982602P 2020-02-27 2020-02-27
US202062982492P 2020-02-27 2020-02-27
US202062982525P 2020-02-27 2020-02-27
US202062982574P 2020-02-27 2020-02-27
US202062982591P 2020-02-27 2020-02-27
US202062982535P 2020-02-27 2020-02-27
US202062982505P 2020-02-27 2020-02-27
US202062982478P 2020-02-27 2020-02-27
US202062982548P 2020-02-27 2020-02-27
US62/982,669 2020-02-27
US62/982,505 2020-02-27
US62/982,525 2020-02-27
US62/982,374 2020-02-27
US62/982,664 2020-02-27
US62/982,535 2020-02-27
US62/982,574 2020-02-27
US62/982,492 2020-02-27
US62/982,548 2020-02-27
US62/982,591 2020-02-27
US62/982,478 2020-02-27
US60/982,469 2020-02-27
US62/982,602 2020-02-27
US62/982,462 2020-02-27
US202062989042P 2020-03-13 2020-03-13
US202062989045P 2020-03-13 2020-03-13
US202062989006P 2020-03-13 2020-03-13
US202062989010P 2020-03-13 2020-03-13
US202062989075P 2020-03-13 2020-03-13
US202062989052P 2020-03-13 2020-03-13
US202062989002P 2020-03-13 2020-03-13
US202062989036P 2020-03-13 2020-03-13
US202062989024P 2020-03-13 2020-03-13
US202062989057P 2020-03-13 2020-03-13
US202062988996P 2020-03-13 2020-03-13
US202062989027P 2020-03-13 2020-03-13
US202062989068P 2020-03-13 2020-03-13
US202062989018P 2020-03-13 2020-03-13
US62/989,045 2020-03-13
US62/989,052 2020-03-13
US62/989,036 2020-03-13
US62/989,024 2020-03-13
US62/989,075 2020-03-13
US62/989,006 2020-03-13
US62/989,027 2020-03-13
US62/989,018 2020-03-13
US62/988,996 2020-03-13
US62/989,010 2020-03-13
US62/989,068 2020-03-13
US62/989,057 2020-03-13
US62/989,002 2020-03-13
US62/989,042 2020-03-13
PCT/US2020/031749 WO2020227457A1 (en) 2019-05-08 2020-05-07 Materials and methods for modulating t cell mediated immunity
AUPCT/US2020/031749 2020-05-07
US202063074655P 2020-09-04 2020-09-04
US202063074946P 2020-09-04 2020-09-04
US202063074676P 2020-09-04 2020-09-04
US202063074893P 2020-09-04 2020-09-04
US202063074903P 2020-09-04 2020-09-04
US202063074925P 2020-09-04 2020-09-04
US202063074749P 2020-09-04 2020-09-04
US202063074854P 2020-09-04 2020-09-04
US202063074735P 2020-09-04 2020-09-04
US202063074759P 2020-09-04 2020-09-04
US202063074962P 2020-09-04 2020-09-04
US202063074839P 2020-09-04 2020-09-04
US202063074937P 2020-09-04 2020-09-04
US202063074700P 2020-09-04 2020-09-04
US63/074,962 2020-09-04
US63/074,749 2020-09-04
US63/074,854 2020-09-04
US63/074,839 2020-09-04
US63/074,937 2020-09-04
US63/074,946 2020-09-04
US63/074,655 2020-09-04
US63/074,735 2020-09-04
US63/074,676 2020-09-04
US63/074,700 2020-09-04
US63/074,893 2020-09-04
US63/074,759 2020-09-04
US63/074,903 2020-09-04
US63/074,925 2020-09-04
US202063112475P 2020-11-11 2020-11-11
US202063112462P 2020-11-11 2020-11-11
US63/112,475 2020-11-11
US63/112,462 2020-11-11
PCT/US2021/019766 WO2021173896A1 (en) 2020-02-27 2021-02-26 Materials and methods for modulating an immune response

Publications (1)

Publication Number Publication Date
AU2021225870A1 true AU2021225870A1 (en) 2022-10-20

Family

ID=77492135

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AU2021225870A Abandoned AU2021225870A1 (en) 2020-02-27 2021-02-26 Materials and methods for modulating an immune response

Country Status (10)

Country Link
US (1) US20220306739A1 (https=)
JP (1) JP2023515199A (https=)
KR (1) KR20220147631A (https=)
CN (1) CN115484981A (https=)
AU (1) AU2021225870A1 (https=)
CA (1) CA3173268A1 (https=)
IL (1) IL295897A (https=)
MX (1) MX2022010664A (https=)
TW (1) TW202144415A (https=)
WO (1) WO2021173896A1 (https=)

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US10501541B2 (en) 2015-01-27 2019-12-10 Lava Therapeutics B.V. Single domain antibodies targeting CD1d
AU2019344300A1 (en) 2018-09-19 2021-04-22 LAVA Therapeutics N.V. Dual acting CD1D immunoglobulin
MX2021010857A (es) 2019-03-11 2021-12-15 Janssen Biotech Inc Anticuerpos biespecificos anti-v(beta17)/anti-cd123.
MA55903A (fr) 2019-05-08 2022-03-16 Janssen Biotech Inc Matières et méthodes pour moduler l'immunité médiée par les lymphocytes t
CN115443150A (zh) 2019-12-17 2022-12-06 德克萨斯大学系统董事会 新型ddr1抗体和其用途
KR20230042035A (ko) 2020-07-08 2023-03-27 라바 테라퓨틱스 엔.브이. Psma와 감마-델타 t 세포 수용체에 결합할 수 있는 항체
WO2022056197A1 (en) 2020-09-11 2022-03-17 Janssen Biotech, Inc. Immune targeting molecules and uses thereof
US20220089737A1 (en) * 2020-09-11 2022-03-24 Janssen Biotech, Inc. Multi-specific immune targeting molecules and uses thereof
TW202227495A (zh) 2020-09-11 2022-07-16 美商健生生物科技公司 用於調節β鏈介導之免疫的方法及組成物
EP4237003A4 (en) 2020-10-28 2025-07-09 Janssen Biotech Inc COMPOSITIONS AND METHODS FOR MODULATING GAMMA DELTA CHAIN-MEDIATED IMMUNITY
CN120076829A (zh) 2022-10-18 2025-05-30 明治制果药业株式会社 T细胞肿瘤的治疗剂
AU2023411024A1 (en) * 2022-12-23 2025-08-07 The Wistar Institute Of Anatomy And Biology Siglec 9 inhibitors and methods of use thereof for enhancing immunotherapy efficacy
TW202537974A (zh) * 2023-11-15 2025-10-01 大陸商上海盛迪醫藥有限公司 Ｔｒｇｖ９結合蛋白及其醫藥用途
WO2025220690A1 (ja) * 2024-04-17 2025-10-23 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｔ細胞腫瘍以外の悪性腫瘍患者に有効な二重特異性抗体

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AU2002351208A1 (en) * 2001-12-03 2003-06-17 Abgenix, Inc. Antibodies against carbonic anhydrase IX (CA IX) tumor antigen
EP1790664A1 (en) * 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
JP2012505654A (ja) * 2008-10-14 2012-03-08 ヤンセン バイオテツク，インコーポレーテツド 抗体をヒト化及び親和性成熟する方法
DK3129404T3 (da) * 2014-04-10 2026-04-20 Lava Therapeutics N V Immunglobuliner, der binder humane vgamma9vdelta2-t-cellereceptorer
CA3297793A1 (en) * 2016-12-26 2026-03-02 Kagoshima University Antibody which binds to myelin oligodendrocyte glycoprotein
EP3743081A4 (en) * 2018-01-23 2021-12-01 New York University SPECIFIC ANTIBODIES OF THE DELTA 1 CHAIN OF THE T-LYMPHOCYTE RECEPTOR
JOP20190116A1 (ar) * 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
CA3101271A1 (en) * 2018-05-24 2019-11-28 Janssen Biotech, Inc. Anti-cd3 antibodies and uses thereof
MA55903A (fr) * 2019-05-08 2022-03-16 Janssen Biotech Inc Matières et méthodes pour moduler l'immunité médiée par les lymphocytes t
JP2023517660A (ja) * 2020-03-13 2023-04-26 ヤンセン バイオテツク，インコーポレーテツド シグレック３／ｃｄ３３に結合させるための材料及び方法

Also Published As

Publication number Publication date
IL295897A (en) 2022-10-01
MX2022010664A (es) 2022-11-30
US20220306739A1 (en) 2022-09-29
JP2023515199A (ja) 2023-04-12
KR20220147631A (ko) 2022-11-03
WO2021173896A1 (en) 2021-09-02
WO2021173896A8 (en) 2022-10-06
TW202144415A (zh) 2021-12-01
CN115484981A (zh) 2022-12-16
CA3173268A1 (en) 2021-09-02

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