AU2021101837A4 - A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof - Google Patents
A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof Download PDFInfo
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- AU2021101837A4 AU2021101837A4 AU2021101837A AU2021101837A AU2021101837A4 AU 2021101837 A4 AU2021101837 A4 AU 2021101837A4 AU 2021101837 A AU2021101837 A AU 2021101837A AU 2021101837 A AU2021101837 A AU 2021101837A AU 2021101837 A4 AU2021101837 A4 AU 2021101837A4
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- piglets
- feed additive
- serine
- powder
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- 239000003674 animal food additive Substances 0.000 title claims abstract description 54
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 230000012010 growth Effects 0.000 title claims abstract description 15
- 230000004083 survival effect Effects 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 53
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 44
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 244000068988 Glycine max Species 0.000 claims abstract description 23
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 23
- 241001465754 Metazoa Species 0.000 claims description 7
- 208000011580 syndromic disease Diseases 0.000 abstract description 8
- 208000035240 Disease Resistance Diseases 0.000 abstract description 5
- 238000009395 breeding Methods 0.000 abstract description 5
- 230000001488 breeding effect Effects 0.000 abstract description 5
- 230000036039 immunity Effects 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 34
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 15
- 102000004420 Creatine Kinase Human genes 0.000 description 9
- 108010042126 Creatine kinase Proteins 0.000 description 9
- 230000002354 daily effect Effects 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- 238000003756 stirring Methods 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
- 241000235646 Cyberlindnera jadinii Species 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 229920000392 Zymosan Polymers 0.000 description 4
- 238000005054 agglomeration Methods 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 4
- 239000000413 hydrolysate Substances 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 235000014590 basal diet Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 230000004129 fatty acid metabolism Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037257 muscle growth Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Birds (AREA)
- Physiology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a serine feed additive capable of improving the survival
rate and growth speed of piglets, and an application of the serine feed additive. The
feed additive comprises serine, a compound yeast powder and a carrier puffed
soybean powder, and preferably comprises in parts by weight: 20-80 parts of serine,
10-40 parts of the compound yeast powder, and 10-40 parts of the carrier puffed
soybean powder. The feed additive disclosed by the invention is suitable for being
added into daily ration of weaned piglets, and is used for helping to enhance disease
resistance and immunity of the piglets, improving a feed utilization rate and a survival
rate of the piglets, and promoting the healthy growth of the piglets and relieving
weaning syndromes of the piglets, so that the breeding benefit of the piglets is
improved.
Description
Specification
A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof
Technical Field The application belongs to the technical field of animal nutrition, in particular relates to a serine feed additive capable of improving the survival rate and growth speed of piglets, and an application of the serine feed additive.
Background Art With the large-scale development of the pig industry, the age of early weaning of piglets in production is getting earlier and earlier. However, piglets are susceptible to weaning emergency syndrome after weaning, and there will be problems such as decreased immune function, high mortality, and high morbidity. The use of antibiotics in the growth stage of piglets can enhance the disease resistance of piglets, but long-term use will reduce the immunity of piglets. How to effectively solve the piglet weaning emergency syndrome is still a difficult problem faced by farmers.
Summary of the Invention The invention aims to provide a serine feed additive capable of improving the survival rate and growth speed of piglets, and an application of the serine feed additive, the invention is used for improving a feed utilization rate in the process of piglet breeding, helping to enhance disease resistance and immunity of the piglets, improving a survival rate of the piglets, and promoting the healthy growth of the piglets and relieving weaning syndromes of the piglets. On the one hand, the invention provides a serine feed additive capable of improving the survival rate and growth speed of piglets, comprising serine, a compound yeast powder and a carrier puffed soybean powder. Preferably, the feed additive comprises in parts by weight: 20-80 parts of serine, -40 parts of the compound yeast powder, and 10-40 parts of the carrier puffed soybean powder. Preferably, the feed additive comprises in parts by weight: 20 parts of serine, 40 parts of the compound yeast powder, and 40 parts of the carrier puffed soybean powder. Preferably, the feed additive comprises in parts by weight: 45 parts of serine, 19
Specification
parts of the compound yeast powder, and 36 parts of the carrier puffed soybean powder. Preferably, the feed additive comprises in parts by weight: 62 parts of serine, 21 parts of the compound yeast powder, and 17 parts of the carrier puffed soybean powder. Preferably, the feed additive comprises in parts by weight: 80 parts of serine, 10 parts of the compound yeast powder, and 10 parts of the carrier puffed soybean powder. Preferably, theyeast content inthe compound yeast powder is >1.0x110 cfu/g. On the other hand, the invention provides the application of the feed additive, wherein the feed additive is suitable for being added into daily ration of animals before feeding. Preferably, the animals are weaned piglets. Preferably, the feed additive is incorporated into the daily ration of animals in an amount of 1 wt% of the daily ration. The invention is suitable for being added into daily ration of weaned piglets, and is used for helping to enhance disease resistance and immunity of the piglets, improving a feed utilization rate and a survival rate of the piglets, and promoting the healthy growth of the piglets and relieving weaning syndromes of the piglets, thereby the breeding benefit of the piglets is improved.
Specific Embodiments of the Invention The invention is described below in detail with reference to specific embodiments, thereby the advantages and features of the invention can be more easily understood by those skilled in the art, so as to make a clearer and clearer definition of the protection scope of the invention. Serine is a non-essential amino acid, which plays a role in fat and fatty acid metabolism and muscle growth. It is the precursor for the synthetic purine, thymine, and choline, and it is also one of the main components of phospholipids, which is very important for maintaining the health of animals. Compound yeast powder is rich in nutrients and physiological activator produced by yeast. The invention provides a feed additive for piglets that combines the nutrition of serine, the nutrition and physiological activator in the compound yeast powder, and at the same time uses the puffed soybean powder as a carrier. The invention is used for improving a feed
Specification
utilization rate in the process of piglet breeding, helping to enhance disease resistance and immunity of the piglets, improving a survival rate of the piglets, and promoting the healthy growth of the piglets and relieving weaning syndromes of the piglets, thereby the breeding benefit of the piglets is improved. The piglet feed additive of the invention is further described in combination with a specific embodiments below. Embodiment 1 The raw materials of the feed additive in the embodiment comprise in parts by weight: 20 parts of serine, 40 parts of the compound yeast powder, and 40 parts of the carrier puffed soybean powder. The compound yeast powder comprises candida utilis, beer yeast, yeast hydrolysate and zymosan, and the yeast content is >1.0x1010 cfu/g. Weighing serine, compound yeast powder and puffed soybean powder without mold or agglomeration, adding them to the mixing container in order under stirring, and stirring and mixing uniformly to obtain feed additive 1. Embodiment 2 The raw materials of the feed additive in the embodiment comprise in parts by weight: 45 parts of serine, 19 parts of the compound yeast powder, and 36 parts of the carrier puffed soybean powder. The compound yeast powder comprises candida utilis, beer yeast, yeast hydrolysate and zymosan, and the yeast content is >1.0x1010 cfu/g. Weighing serine, compound yeast powder and puffed soybean powder without mold or agglomeration, adding them to the mixing container in order under stirring, and stirring and mixing uniformly to obtain feed additive 2. Embodiment 3 The raw materials of the feed additive in the embodiment comprise in parts by weight: 62 parts of serine, 21 parts of the compound yeast powder, and 17 parts of the carrier puffed soybean powder. The compound yeast powder comprises candida utilis, beer yeast, yeast hydrolysate and zymosan, and the yeast content is >1.Ox10 10 cfu/g. Weighing serine, compound yeast powder and puffed soybean powder without mold or agglomeration, adding them to the mixing container in order under stirring, and stirring and mixing uniformly to obtain feed additive 3. Embodiment 4 The raw materials of the feed additive in the embodiment comprise in parts by weight: 80 parts of serine, 10 parts of the compound yeast powder, and 10 parts of the carrier puffed soybean powder. The compound yeast powder comprises candida utilis,
Specification
beer yeast, yeast hydrolysate and zymosan, and the yeast content is >1.Ox10 10 cfu/g. Weighing serine, compound yeast powder and puffed soybean powder without mold or agglomeration, adding them to the mixing container in order under stirring, and stirring and mixing uniformly to obtain feed additive 4. Test 1: The effect of feed additives on the growth and weaning stress syndromes of weaned piglets 150 piglets of 45-day-old DurocxLandracexYorkie with good development, strong appetite, health, similar genetic basis, and similar initial weight were selected and randomly divided into 5 groups, comprising a control group and 4 test groups, each group 3 repetitions, each with 10 piglets repetitions, half of male and female. Each group of piglets was fed with corresponding daily ration, the control group was fed with regular piglet basal diets, and the rations of 4 test groups were piglet basal diets mixed with lwt% of corresponding feed additives. The composition and nutritional level of the piglet's daily ration are formulated with reference to the nutritional requirements of 8-20kg weaned piglets in the pig feeding standard (NY/T65-2004). The piglets of each group are kept in the same pig house, separated from each other. Mixing the feed additives into the feed and feed them 3 times a day (7:00, 12:00, and 17:00), each repeated 10 piglets in the same pig house eat together, freely feed and drink water. The temperature in the pig house is kept at 26~32C, and the
temperature and relative humidity are measured and recorded at 7:00, 12:00 and 16:30 every day. Pre-feeding was carried out for 3 days, and then a 43-day formal test was carried out, all test piglets were weighed on an empty stomach on the first day and the end of the formal test. Observing and recording the health status of all test piglets every day, accurately recording the feed intake and death of each group of test piglets, and calculating the average daily gain, feed-to-weight ratio, diarrhea rate, and mortality of each group of piglets after the end of the test. The results are shown in Table 1. Table 1
Specification
Groups Average daily gain (g/d) Feed-to-weight ratio (%) Diarrhea rate (%) Mortality(%)
Feed additive 1 569.77 1.63 5.60 0 Feed additive 2 602.33 1.57 6.12 0 Feed additive 3 613.95 1.42 7.10 3.3
Feed additive 4 623.26 1.38 5.44 0 Control group 497.67 1.57 16.24 13.3
From the data in Table 1, it can be seen that compared with the control group, the average daily gain of the four groups of piglets fed with feed additives increased by 14.49%, 21.03%, 23.36%, and 25.24% respectively; the average feed-to-weight ratio respectively reduced by 6.85%, 10.29%, 18.86%, 21.14%; the average diarrhea rate was reduced by 65.52%, 62.32%, 56.28%, 66.50%, respectively; piglet mortality was reduced by 13.3%, 13.3%, 10%, 13.3%. What shows that the feed additives 1 to 4 prepared above can all promote the growth of weaned piglets, improve feed utilization, reduce the rate of piglet diarrhea, and thereby increasing the survival rate of piglets. On the day 14, 28, and 42 of the test, 3 piglets were randomly selected for each repetition to collect 8mL of blood from the anterior vena cava, after clotting, the blood was centrifuged at 4°C, 1400r/min for 10 minutes, and the serum was collected and stored at -20°C for later use. Determination of serum creatine kinase (CK) activity and glucose (GLU) content. The results are shown in Table 2. Table 2
Groups CK (U/mL) GLU (rnol/L) Day 14 Day 28 Day 42 Day 14 Day 28 Day 42 Feed additive 1 0.42+0.03 0.58+0.02 0.48+0.02 4.65+0.02 4.62+0.03 5.64+0.03 Feed additive 2 0.31±0.05 0.61±0.08 0.4610.01 4.61±0.01 4.55+0.01 5.57±0.02 Feed additive 3 0.32±0.02 0.56±0.03 0.43±0.01 4.76a0.02 4.60±0.02 5.72±0.03 Feed additive 4 0.30±0.03 0.54b0.00 0.41+0.02 4.58A0.03 4.53=0.02 5.66+0.02 Control group 0.65±0.01 0.74±0.02 0.68±0.01 4.57±0.01 4.60±0.02 5.80±0.01
It can be seen from the data in Table 2 that compared with the control group, the serum creatine kinase (CK) content of the 4 groups of piglets fed with feed additives was significantly reduced, however the glucose (GLU) content did not change significantly. Creatine kinase (CK) and glucose (GLU) are two important indicators of stress in weaned piglets. CK mainly exists in the myocardium, and the content of serum is less when the piglets are normal. Only when the body is diseased or the body tissue is damaged, it will increase. When the weaned piglets are under stress, the content of CK in the serum increases rapidly, the GLU produced by starch digestion is less, the serum GLU concentration will also decrease, and the energy utilization rate will decrease. The results in Table 2 show that the feed additives 1 to 4 prepared
Specification
above can all reduce the weaning stress response of the piglets, alleviate the weaning stress syndrome of the piglets, and promote the healthy growth of the weaned piglets. The above are only the embodiments of the invention, and do not limit the scope of the invention. Any equivalent structural transformation made by using the content of the invention, or directly or indirectly applied in other related technical fields, are included in the same way, should be included within the scope of patent protection of the invention.
Claims (9)
1. A serine feed additive capable of improving the survival rate and growth speed of piglets, comprising serine, a compound yeast powder and a carrier puffed soybean powder.
2. The feed additive of claim 1, wherein comprising in parts by weight: 20-80 parts of serine, 10-40 parts of the compound yeast powder, and 10-40 parts of the carrier puffed soybean powder.
3. The feed additive of claim 2, wherein comprising in parts by weight: 20 parts of serine, 40 parts of the compound yeast powder, and 40 parts of the carrier puffed soybean powder.
4. The feed additive of claim 2, wherein comprising in parts by weight: 45 parts of serine, 19 parts of the compound yeast powder, and 36 parts of the carrier puffed soybean powder.
5. The feed additive of claim 2, wherein comprising in parts by weight: 62 parts of serine, 21 parts of the compound yeast powder, and 17 parts of the carrier puffed soybean powder.
6. The feed additive of claim 2, wherein comprising in parts by weight: 80 parts of serine, 10 parts of the compound yeast powder, and 10 parts of the carrier puffed soybean powder.
7. The feed additive of claim 1 to 6, wherein the yeast content in the compound yeast powder is >1.0x10 10 cfu/g.
8. The application of the feed additive of claims 1 to 7, wherein the feed additive is suitable for being added into daily ration of animals before feeding.
9. The application of claim 8, the animals are weaned piglets. The application of claim 8, the feed additive is incorporated into the daily ration of animals in an amount of 1 wt% of the daily ration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021101837A AU2021101837A4 (en) | 2021-04-09 | 2021-04-09 | A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021101837A AU2021101837A4 (en) | 2021-04-09 | 2021-04-09 | A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2021101837A4 true AU2021101837A4 (en) | 2021-06-03 |
Family
ID=76132863
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021101837A Ceased AU2021101837A4 (en) | 2021-04-09 | 2021-04-09 | A Serine Feed Additive Capable Of Improving The Survival Rate And Growth Speed Of Piglets, And An Application Thereof |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2021101837A4 (en) |
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2021
- 2021-04-09 AU AU2021101837A patent/AU2021101837A4/en not_active Ceased
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