AU2020351698A1 - IL-15 fusion peptides used to treat cancer - Google Patents
IL-15 fusion peptides used to treat cancer Download PDFInfo
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- AU2020351698A1 AU2020351698A1 AU2020351698A AU2020351698A AU2020351698A1 AU 2020351698 A1 AU2020351698 A1 AU 2020351698A1 AU 2020351698 A AU2020351698 A AU 2020351698A AU 2020351698 A AU2020351698 A AU 2020351698A AU 2020351698 A1 AU2020351698 A1 AU 2020351698A1
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- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
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- 229940069338 potassium sorbate Drugs 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
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- 238000011321 prophylaxis Methods 0.000 description 1
- 238000012342 propidium iodide staining Methods 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
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- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1913804.9 | 2019-09-25 | ||
| GB201913804A GB201913804D0 (en) | 2019-09-25 | 2019-09-25 | Fusion polypeptides |
| PCT/GB2020/052328 WO2021058973A1 (en) | 2019-09-25 | 2020-09-25 | Il-15 fusion peptides used to treat cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2020351698A1 true AU2020351698A1 (en) | 2022-03-31 |
Family
ID=68425465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020351698A Abandoned AU2020351698A1 (en) | 2019-09-25 | 2020-09-25 | IL-15 fusion peptides used to treat cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220372097A1 (enExample) |
| EP (1) | EP4034552A1 (enExample) |
| JP (1) | JP2023502843A (enExample) |
| CN (1) | CN114651014A (enExample) |
| AU (1) | AU2020351698A1 (enExample) |
| CA (1) | CA3155100A1 (enExample) |
| GB (1) | GB201913804D0 (enExample) |
| IL (1) | IL291560A (enExample) |
| WO (1) | WO2021058973A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| GB202304385D0 (en) | 2023-03-24 | 2023-05-10 | Prostate Cancer Res | Combinatorial IL-15 therapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| GB9614871D0 (en) | 1996-07-15 | 1996-09-04 | Smithkline Beecham Plc | Compounds |
| US20070160578A1 (en) * | 2005-12-14 | 2007-07-12 | The Gov. Of The Usa As Represented By The Secretary Of The Dep. Of Health And Human Services | Expansion of natural killer and CD8 T-cells with IL-15R/ligand activator complexes |
| GB0915519D0 (en) | 2009-09-04 | 2009-10-07 | King S College London | Ntithrombotic compounds |
| WO2012054509A2 (en) * | 2010-10-22 | 2012-04-26 | Dana-Farber Cancer Institute, Inc. | Discovery of regulatory t cells programmed to suppress an immune response |
| WO2018161026A1 (en) * | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
| WO2019006472A1 (en) * | 2017-06-30 | 2019-01-03 | Xencor, Inc. | TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS |
| CA3086040A1 (en) * | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| AU2019228381B2 (en) * | 2018-02-28 | 2021-12-16 | Pfizer Inc. | IL-15 variants and uses thereof |
| CA3090407A1 (en) * | 2018-03-01 | 2019-09-06 | Glycotope Gmbh | Fusion protein constructs comprising an anti-muc1 antibody and il-15 |
-
2019
- 2019-09-25 GB GB201913804A patent/GB201913804D0/en not_active Ceased
-
2020
- 2020-09-25 CA CA3155100A patent/CA3155100A1/en active Pending
- 2020-09-25 AU AU2020351698A patent/AU2020351698A1/en not_active Abandoned
- 2020-09-25 US US17/762,358 patent/US20220372097A1/en not_active Abandoned
- 2020-09-25 WO PCT/GB2020/052328 patent/WO2021058973A1/en not_active Ceased
- 2020-09-25 CN CN202080067412.0A patent/CN114651014A/zh active Pending
- 2020-09-25 JP JP2022519139A patent/JP2023502843A/ja active Pending
- 2020-09-25 EP EP20793045.4A patent/EP4034552A1/en not_active Withdrawn
-
2022
- 2022-03-21 IL IL291560A patent/IL291560A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220372097A1 (en) | 2022-11-24 |
| EP4034552A1 (en) | 2022-08-03 |
| CN114651014A (zh) | 2022-06-21 |
| IL291560A (en) | 2022-05-01 |
| CA3155100A1 (en) | 2021-04-01 |
| JP2023502843A (ja) | 2023-01-26 |
| WO2021058973A1 (en) | 2021-04-01 |
| GB201913804D0 (en) | 2019-11-06 |
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| HB | Alteration of name in register |
Owner name: KING'S COLLEGE LONDON Free format text: FORMER NAME(S): KING'S COLLEGE LONDON; PROSTATE CANCER RESEARCH CENTRE Owner name: PROSTATE CANCER RESEARCH Free format text: FORMER NAME(S): KING'S COLLEGE LONDON; PROSTATE CANCER RESEARCH CENTRE |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |