AU2020345915A1 - Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept - Google Patents

Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept Download PDF

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Publication number
AU2020345915A1
AU2020345915A1 AU2020345915A AU2020345915A AU2020345915A1 AU 2020345915 A1 AU2020345915 A1 AU 2020345915A1 AU 2020345915 A AU2020345915 A AU 2020345915A AU 2020345915 A AU2020345915 A AU 2020345915A AU 2020345915 A1 AU2020345915 A1 AU 2020345915A1
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Australia
Prior art keywords
eye
unit dose
raav particles
weeks
administration
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Pending
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AU2020345915A
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English (en)
Inventor
Mehdi Gasmi
Szilard Kiss
Aaron Osborne
Adam TURPCU
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Adverum Biotechnologies Inc
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Adverum Biotechnologies Inc
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Priority claimed from PCT/US2019/062066 external-priority patent/WO2021050094A1/en
Application filed by Adverum Biotechnologies Inc filed Critical Adverum Biotechnologies Inc
Publication of AU2020345915A1 publication Critical patent/AU2020345915A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
    • C12N2710/14144Chimeric viral vector comprising heterologous viral elements for production of another viral vector
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    • C12N2750/14011Parvoviridae
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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AU2020345915A 2019-09-11 2020-09-10 Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept Pending AU2020345915A1 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201962899070P 2019-09-11 2019-09-11
US62/899,070 2019-09-11
US201962913648P 2019-10-10 2019-10-10
US62/913,648 2019-10-10
AUPCT/US2019/062066 2019-11-18
PCT/US2019/062066 WO2021050094A1 (en) 2019-09-11 2019-11-18 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
US202062959784P 2020-01-10 2020-01-10
US62/959,784 2020-01-10
US202062971835P 2020-02-07 2020-02-07
US62/971,835 2020-02-07
US202063019190P 2020-05-01 2020-05-01
US63/019,190 2020-05-01
US202063030819P 2020-05-27 2020-05-27
US63/030,819 2020-05-27
US202063063203P 2020-08-07 2020-08-07
US63/063,203 2020-08-07
PCT/US2020/050079 WO2021050649A1 (en) 2019-09-11 2020-09-10 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Publications (1)

Publication Number Publication Date
AU2020345915A1 true AU2020345915A1 (en) 2022-03-24

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ID=72644941

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AU2020345915A Pending AU2020345915A1 (en) 2019-09-11 2020-09-10 Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept

Country Status (10)

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EP (1) EP4027983A1 (ja)
JP (1) JP2022547541A (ja)
KR (1) KR20220062353A (ja)
CN (1) CN114375195A (ja)
AU (1) AU2020345915A1 (ja)
BR (1) BR112022004027A2 (ja)
CA (1) CA3148376A1 (ja)
IL (1) IL291182A (ja)
MX (1) MX2022002961A (ja)
WO (1) WO2021050649A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112023019056A2 (pt) 2021-04-27 2024-01-16 Adverum Biotechnologies Inc Métodos para tratar doenças oculares usando variantes de aav2 que codificam aflibercepte
TW202313096A (zh) * 2021-05-28 2023-04-01 大陸商江蘇恆瑞醫藥股份有限公司 衣殼變異的重組腺相關病毒及其應用
WO2023028457A1 (en) * 2021-08-23 2023-03-02 Duke University Compositions for and methods of long-term integration of circuits using connexins
WO2023158990A1 (en) * 2022-02-16 2023-08-24 Adverum Biotechnologies, Inc. Method of reducing cst fluctuation in neovascular amd by a recombinant adeno-associated virus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3693025B1 (en) 2011-04-22 2021-10-13 The Regents of The University of California Adeno-associated virus virions with variant capsid and methods of use thereof
CN109641065A (zh) * 2016-06-16 2019-04-16 阿德夫拉姆生物技术股份有限公司 使用aav2变体和阿柏西普治疗amd
AU2018234918B2 (en) 2017-03-17 2023-11-02 Adverum Biotechnologies, Inc. Compositions and methods for enhanced gene expression

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Publication number Publication date
KR20220062353A (ko) 2022-05-16
CN114375195A (zh) 2022-04-19
WO2021050649A1 (en) 2021-03-18
IL291182A (en) 2022-05-01
EP4027983A1 (en) 2022-07-20
BR112022004027A2 (pt) 2022-05-31
MX2022002961A (es) 2022-04-06
CA3148376A1 (en) 2021-03-18
JP2022547541A (ja) 2022-11-14

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