AU2020325690A1 - CAR T-cells against BCMA for the treatment of Multiple myeloma - Google Patents

CAR T-cells against BCMA for the treatment of Multiple myeloma Download PDF

Info

Publication number
AU2020325690A1
AU2020325690A1 AU2020325690A AU2020325690A AU2020325690A1 AU 2020325690 A1 AU2020325690 A1 AU 2020325690A1 AU 2020325690 A AU2020325690 A AU 2020325690A AU 2020325690 A AU2020325690 A AU 2020325690A AU 2020325690 A1 AU2020325690 A1 AU 2020325690A1
Authority
AU
Australia
Prior art keywords
cells
cell
ari2m
domain
ari2h
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2020325690A
Other languages
English (en)
Inventor
Manel JUAN OTERO
Beatriz MARTÍN ANTONIO
Lorena PÉREZ AMILL
Guillermo SUÑE RODRIGUEZ
Álvaro URBANO ISPIZUA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat de Barcelona UB
Hospital Clinic de Barcelona
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Original Assignee
Universitat de Barcelona UB
Hospital Clinic de Barcelona
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat de Barcelona UB, Hospital Clinic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer filed Critical Universitat de Barcelona UB
Publication of AU2020325690A1 publication Critical patent/AU2020325690A1/en
Assigned to FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, UNIVERSITAT DE BARCELONA, HOSPITAL CLINIC DE BARCELONA, FUNDACIÓ DE RECERCA CLINIC BARCELONA-INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER reassignment FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA Request for Assignment Assignors: FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, HOSPITAL CLINIC DE BARCELONA, INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS), UNIVERSITAT DE BARCELONA
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
AU2020325690A 2019-08-02 2020-08-03 CAR T-cells against BCMA for the treatment of Multiple myeloma Pending AU2020325690A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382673.2 2019-08-02
EP19382673 2019-08-02
PCT/EP2020/071831 WO2021023721A1 (en) 2019-08-02 2020-08-03 Car t-cells against bcma for the treatment of multiple myeloma

Publications (1)

Publication Number Publication Date
AU2020325690A1 true AU2020325690A1 (en) 2022-03-03

Family

ID=67658496

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020325690A Pending AU2020325690A1 (en) 2019-08-02 2020-08-03 CAR T-cells against BCMA for the treatment of Multiple myeloma

Country Status (18)

Country Link
US (1) US12509525B2 (https=)
EP (2) EP4272837A3 (https=)
JP (1) JP7729561B2 (https=)
AU (1) AU2020325690A1 (https=)
CA (1) CA3148930A1 (https=)
DK (1) DK4007777T5 (https=)
ES (1) ES2971033T3 (https=)
FI (1) FI4007777T3 (https=)
HR (1) HRP20240037T1 (https=)
HU (1) HUE064890T2 (https=)
LT (1) LT4007777T (https=)
PL (1) PL4007777T3 (https=)
PT (1) PT4007777T (https=)
RS (1) RS65094B1 (https=)
SI (1) SI4007777T1 (https=)
SM (1) SMT202400013T1 (https=)
WO (1) WO2021023721A1 (https=)
ZA (1) ZA202201166B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250021397A (ko) * 2022-02-09 2025-02-12 하다지트 메디칼 리서치 써비시즈 앤드 디벨롭먼트 리미티드 면역 관련 질환을 표적으로 하는 항-bcma car, 조성물 및 이의 방법
EP4378953A1 (en) * 2022-12-02 2024-06-05 Universitat de Barcelona Cd229 targeting moiety for the tratment of cd229 positive cancer
WO2025141187A1 (en) * 2023-12-29 2025-07-03 Fundación Para La Investigación Biomédica Del Hospital Universitario 12 De Octubre T cells expressing anti-bcma/anti-cd3 bispecific antibodies and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5674704A (en) 1993-05-07 1997-10-07 Immunex Corporation Cytokine designated 4-IBB ligand
NO3051026T3 (https=) 2011-10-21 2018-07-28
WO2014068079A1 (en) 2012-11-01 2014-05-08 Max-Delbrück-Centrum für Molekulare Medizin An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases
ES2546743B1 (es) 2014-03-28 2016-07-07 Institut D'investigació Biomèdica De Bellvitge (Idibell) Marcadores mitocondriales de enfermedades neurodegenerativas
KR102526945B1 (ko) 2014-04-30 2023-04-27 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 Ｃｄ269에 대한 인간화 항체
KR20170066546A (ko) 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
SG10202012157QA (en) 2016-06-07 2021-01-28 Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
CN108004259B (zh) * 2016-11-02 2020-06-30 上海恒润达生生物科技有限公司 靶向b细胞成熟抗原的嵌合抗原受体及其用途
CN108285489A (zh) * 2017-01-09 2018-07-17 上海恒润达生生物科技有限公司 靶向BCMA-BBz-tEGFR的嵌合抗原受体及其用途
CN108395478A (zh) 2017-02-04 2018-08-14 上海恒润达生生物科技有限公司 靶向bcma的嵌合抗原受体并对其双重修饰的方法及其用途
MX2019013514A (es) * 2017-05-12 2020-01-20 Crispr Therapeutics Ag Materiales y metodos para modificar celulas por ingenieria genetica y usos de los mismos en inmunooncologia.
ES2953362T3 (es) 2018-03-13 2023-11-10 Sepsia Therapeutics S L Péptidos de unión bacteriana para el tratamiento de enfermedades infecciosas y procesos inflamatorios relacionados

Also Published As

Publication number Publication date
US20220267459A1 (en) 2022-08-25
ZA202201166B (en) 2022-10-26
DK4007777T5 (da) 2024-08-05
DK4007777T3 (da) 2024-01-15
PL4007777T3 (pl) 2024-03-11
SI4007777T1 (sl) 2024-03-29
JP7729561B2 (ja) 2025-08-26
EP4272837A3 (en) 2024-02-28
FI4007777T3 (fi) 2024-01-11
CA3148930A1 (en) 2021-02-11
US12509525B2 (en) 2025-12-30
SMT202400013T1 (it) 2024-03-13
EP4272837A2 (en) 2023-11-08
EP4007777A1 (en) 2022-06-08
WO2021023721A1 (en) 2021-02-11
HUE064890T2 (hu) 2024-04-28
HRP20240037T1 (hr) 2024-03-29
RS65094B1 (sr) 2024-02-29
JP2022542443A (ja) 2022-10-03
PT4007777T (pt) 2024-01-12
ES2971033T3 (es) 2024-06-03
LT4007777T (lt) 2024-02-12
EP4007777B1 (en) 2023-10-11

Similar Documents

Publication Publication Date Title
US20260116982A1 (en) Car t-cells for the treatment of cd1a-positive cancer
EP4007777B1 (en) Car t-cells against bcma for the treatment of multiple myeloma
JP2024526840A (ja) がんを処置するためのチェックポイント阻害剤と腫瘍溶解性ウイルスの組合せ
Kim et al. Current trends and innovative approaches in cancer immunotherapy
JP7545139B2 (ja) Ｂ細胞急性リンパ芽球性白血病（ｂ－ａｌｌ）の処置のためのｃｄ２２標的化部分
EP4378953A1 (en) Cd229 targeting moiety for the tratment of cd229 positive cancer
WO2022079270A1 (en) Anti-gpc4 single domain antibodies
EP4417623A1 (en) Ccr9 targeting moiety for the treatment of ccr9-positive cancer
HK40116152A (zh) 用於治疗cd1a阳性癌症的car t细胞
WO2025153636A1 (en) INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2 (IL13Ralpha2) TARGETING MOIETIES FOR THE TREATMENT AND PREVENTION OF IL13Ralpha2-POSITIVE CANCER
HK40120698A (zh) 用於治疗cd1a阳性癌症的人源化cd1a靶向部分

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Free format text: FORMER APPLICANT(S): FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA; HOSPITAL CLINIC DE BARCELONA; INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS); UNIVERSITAT DE BARCELONA

Owner name: FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Free format text: FORMER APPLICANT(S): FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA; HOSPITAL CLINIC DE BARCELONA; INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS); UNIVERSITAT DE BARCELONA

Owner name: HOSPITAL CLINIC DE BARCELONA

Free format text: FORMER APPLICANT(S): FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA; HOSPITAL CLINIC DE BARCELONA; INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS); UNIVERSITAT DE BARCELONA

Owner name: UNIVERSITAT DE BARCELONA

Free format text: FORMER APPLICANT(S): FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA; HOSPITAL CLINIC DE BARCELONA; INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (IDIBAPS); UNIVERSITAT DE BARCELONA