AU2020320171B2 - YAP inhibition for wound healing - Google Patents

YAP inhibition for wound healing Download PDF

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Publication number
AU2020320171B2
AU2020320171B2 AU2020320171A AU2020320171A AU2020320171B2 AU 2020320171 B2 AU2020320171 B2 AU 2020320171B2 AU 2020320171 A AU2020320171 A AU 2020320171A AU 2020320171 A AU2020320171 A AU 2020320171A AU 2020320171 B2 AU2020320171 B2 AU 2020320171B2
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AU
Australia
Prior art keywords
wound
enfs
days
yap
skin
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AU2020320171A
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English (en)
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AU2020320171A1 (en
Inventor
Mimi BORRELLI
Michael Francis DAVITT
Heather Elizabeth DESJARDINS-PARK
Michael T. Longaker
Shamik MASCHARAK
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020320171A 2019-07-26 2020-07-24 YAP inhibition for wound healing Active AU2020320171B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962879369P 2019-07-26 2019-07-26
US62/879,369 2019-07-26
PCT/US2020/043420 WO2021021607A2 (en) 2019-07-26 2020-07-24 Yap inhibition for wound healing

Publications (2)

Publication Number Publication Date
AU2020320171A1 AU2020320171A1 (en) 2022-02-17
AU2020320171B2 true AU2020320171B2 (en) 2025-05-29

Family

ID=74229013

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020320171A Active AU2020320171B2 (en) 2019-07-26 2020-07-24 YAP inhibition for wound healing

Country Status (10)

Country Link
US (1) US20220313658A1 (enExample)
EP (1) EP4003334A4 (enExample)
JP (1) JP2022541572A (enExample)
KR (1) KR20220041154A (enExample)
CN (1) CN114401718A (enExample)
AU (1) AU2020320171B2 (enExample)
BR (1) BR112022001196A2 (enExample)
CA (1) CA3144185A1 (enExample)
IL (1) IL289923A (enExample)
WO (1) WO2021021607A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102550631B1 (ko) * 2021-03-16 2023-07-03 (주)파인헬스케어 인공지능을 이용한 욕창 단계 평가 및 치료 추천을 제공하는 장치 및 방법
CA3220398A1 (en) * 2021-07-30 2023-02-02 Geoffrey Gurtner Mechanotransduction disruption mediation in skin grafting methods and compositions for use in practicing the same
US20240366565A1 (en) * 2021-09-09 2024-11-07 The Board Of Trustees Of The Leland Stanford Junior University Use of Verteporfin to Modulate Wound Healing After an Ocular Surgical Procedure or Ocular Injury
CN114288474A (zh) * 2021-12-27 2022-04-08 湖北中部医疗科技有限公司 一种促毛囊再生用真皮层、人工皮肤及其制备方法
EP4514393A4 (en) * 2022-04-28 2026-04-01 Univ Leland Stanford Junior PIEZO-ELECTRIC INHIBITION FOR Wound Healing
CN116694089B (zh) * 2022-09-19 2024-03-26 广州贝奥吉因生物科技股份有限公司 一种用于抑制瘢痕的水凝胶及其制备方法和应用
CN116602265B (zh) * 2023-05-25 2024-05-14 北京工业大学 一种用于建立瘢痕疙瘩动物模型的智能控制系统及方法
CN117679393A (zh) * 2023-12-04 2024-03-12 中山大学附属第一医院 一种负载维替泊芬治疗增生性瘢痕的生物粘性纳米缓释颗粒
US20260115352A1 (en) 2024-10-28 2026-04-30 Cilag Gmbh International Verteporfin Containing Silicone Topical Skin Adhesive for Wound Closure and Reduced Scarring

Family Cites Families (9)

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US20060140984A1 (en) * 2002-10-25 2006-06-29 Foamix Ltd. Cosmetic and pharmaceutical foam
GB0823265D0 (en) * 2008-12-20 2009-01-28 Convatec Technologies Inc Antimicrobial Composition
DE102010009572A1 (de) * 2010-02-26 2011-09-01 Euroderm Gmbh Verfahren zum Begünstigen der Heilung von Hautwunden unter Verwendung der Zellen der Haarwurzelscheide, Präparat und Herstellverfahren
JP2014500275A (ja) * 2010-12-06 2014-01-09 フォリカ，インコーポレイテッド 禿頭症を治療するため、および毛髪の成長を促進するための方法
US9655967B2 (en) * 2011-12-09 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of focal adhesion kinase for control of scar tissue formation
KR101385196B1 (ko) * 2012-05-17 2014-04-14 주식회사 유니크메디케어 광 조사를 이용한 광감각제―펩타이드를 유효성분으로 포함하는 발모 개선 또는 촉진용 조성물 및 이를 이용한 방법
US20150157584A1 (en) * 2012-06-11 2015-06-11 The J. David Gladstone Institutes Inhibitors of hippo-yap signaling pathway
EP2897689A4 (en) * 2012-09-24 2016-03-30 Cormatrix Cardiovascular Inc COMPOSITIONS AND METHODS OF TREATING ALOPEZIA
IL248468A0 (en) * 2016-10-13 2017-01-31 Technion Res & Dev Foundation Use of caspase-3 inhibitors and caspase-3 activators in the manufacture of medicament for treating cancer and wound healing

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Barnes, L.D.; et al. "The effect of photodynamic therapy on squamous cell carcinoma in a murine model: Evaluation of time between intralesional injection to laser irradiation." Vet. J. 2009, 180, 60-65. *
Oku, Y.; et al. "Small molecules inhibiting the nuclear localization of YAP/TAZfor chemotherapeutics and chemosensitizers against breast cancers." FEBS Open Bio 2015, 5, 1, 542-549. DOI: 10.1016/j.fob.2015.06.007 *
Scott, L.J. & Goa, K.L. "Verteporfin" Drugs & Aging 2000, 16, 2, 139-146. *
Shamik, M.; et al. Conference Abstract, PLASTIC SURGERY RESEARCH COUNCIL, 64th Annual Meeting, 2 May 2019. https://ps-rc.org/meeting/abstracts/2019/5.cgi# *

Also Published As

Publication number Publication date
IL289923A (en) 2022-03-01
BR112022001196A2 (pt) 2022-03-15
US20220313658A1 (en) 2022-10-06
KR20220041154A (ko) 2022-03-31
EP4003334A2 (en) 2022-06-01
CA3144185A1 (en) 2021-02-04
CN114401718A (zh) 2022-04-26
AU2020320171A1 (en) 2022-02-17
WO2021021607A3 (en) 2021-04-08
EP4003334A4 (en) 2023-08-16
WO2021021607A2 (en) 2021-02-04
JP2022541572A (ja) 2022-09-26

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