AU2020315878A1 - Immunomodulatory antibodies and methods of use thereof - Google Patents

Immunomodulatory antibodies and methods of use thereof Download PDF

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Publication number
AU2020315878A1
AU2020315878A1 AU2020315878A AU2020315878A AU2020315878A1 AU 2020315878 A1 AU2020315878 A1 AU 2020315878A1 AU 2020315878 A AU2020315878 A AU 2020315878A AU 2020315878 A AU2020315878 A AU 2020315878A AU 2020315878 A1 AU2020315878 A1 AU 2020315878A1
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AU
Australia
Prior art keywords
antibody
amino acid
acid sequence
cell
identity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2020315878A
Other languages
English (en)
Inventor
Mark E. Branum
Siddarth Chandrasekaran
Melissa L. CONERLY
Peter Probst
Kamal D. Puri
Randi M. SIMMONS
Tyrel T. SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OncoResponse Inc
Original Assignee
OncoResponse Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OncoResponse Inc filed Critical OncoResponse Inc
Publication of AU2020315878A1 publication Critical patent/AU2020315878A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2020315878A 2019-07-19 2020-07-17 Immunomodulatory antibodies and methods of use thereof Abandoned AU2020315878A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962876580P 2019-07-19 2019-07-19
US201962876579P 2019-07-19 2019-07-19
US62/876,580 2019-07-19
US62/876,579 2019-07-19
US201962878265P 2019-07-24 2019-07-24
US62/878,265 2019-07-24
PCT/US2020/042668 WO2021016128A1 (en) 2019-07-19 2020-07-17 Immunomodulatory antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
AU2020315878A1 true AU2020315878A1 (en) 2022-03-03

Family

ID=74193810

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020315878A Abandoned AU2020315878A1 (en) 2019-07-19 2020-07-17 Immunomodulatory antibodies and methods of use thereof

Country Status (14)

Country Link
US (6) US11634501B2 (https=)
EP (1) EP4004051A4 (https=)
JP (2) JP7852904B2 (https=)
KR (1) KR20220035452A (https=)
CN (1) CN114423787B (https=)
AU (1) AU2020315878A1 (https=)
BR (1) BR112022000876A2 (https=)
CA (1) CA3147103A1 (https=)
IL (1) IL289829A (https=)
MX (1) MX2022000726A (https=)
PH (1) PH12022550141A1 (https=)
TW (1) TW202116809A (https=)
UY (1) UY38797A (https=)
WO (1) WO2021016128A1 (https=)

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BR112023014418A2 (pt) * 2021-01-20 2023-10-31 Oncoresponse Inc Anticorpos imunomoduladores e usos dos mesmos
EP4281481A1 (en) * 2021-01-20 2023-11-29 Oncoresponse, Inc. Use of immunomodulatory antibodies to treat fibrotic diseases
EP4304647A1 (en) * 2021-03-08 2024-01-17 MedImmune, LLC Antibodies directed against gdf-15
US20250179191A1 (en) * 2021-08-30 2025-06-05 Ming-Tain Lai Bispecific dendritic cell engager and uses thereof
WO2023034963A2 (en) * 2021-09-03 2023-03-09 Oncoresponse, Inc. Combinations of immunotherapies and uses thereof
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WO2025114555A1 (en) 2023-11-30 2025-06-05 Oncospear Aps Anti-cd163 antibodies with improved adcc capabilities

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Also Published As

Publication number Publication date
WO2021016128A1 (en) 2021-01-28
TW202116809A (zh) 2021-05-01
UY38797A (es) 2021-01-29
US11634501B2 (en) 2023-04-25
US11034770B2 (en) 2021-06-15
US20260103535A1 (en) 2026-04-16
JP2026026087A (ja) 2026-02-16
US12195549B2 (en) 2025-01-14
JP2022540806A (ja) 2022-09-20
CN114423787B (zh) 2025-01-24
EP4004051A4 (en) 2023-08-23
US20210253733A1 (en) 2021-08-19
CN114423787A (zh) 2022-04-29
US20220289861A1 (en) 2022-09-15
KR20220035452A (ko) 2022-03-22
PH12022550141A1 (en) 2023-12-04
CA3147103A1 (en) 2021-01-28
US20240101696A1 (en) 2024-03-28
IL289829A (en) 2022-03-01
JP7852904B2 (ja) 2026-04-28
BR112022000876A2 (pt) 2022-04-26
US20240239914A1 (en) 2024-07-18
MX2022000726A (es) 2022-02-10
US20210047424A1 (en) 2021-02-18
EP4004051A1 (en) 2022-06-01
US11827715B2 (en) 2023-11-28

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