AU2020295485A1 - Structurally defined siRNA-dual variable domain immunoglobulin conjugates - Google Patents

Structurally defined siRNA-dual variable domain immunoglobulin conjugates Download PDF

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Publication number
AU2020295485A1
AU2020295485A1 AU2020295485A AU2020295485A AU2020295485A1 AU 2020295485 A1 AU2020295485 A1 AU 2020295485A1 AU 2020295485 A AU2020295485 A AU 2020295485A AU 2020295485 A AU2020295485 A AU 2020295485A AU 2020295485 A1 AU2020295485 A1 AU 2020295485A1
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Australia
Prior art keywords
conjugate
antisense strand
seq
dsrna
linker
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AU2020295485A
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English (en)
Inventor
Kevin Fitzgerald
Alexander V. KEL'IN
Alex R. NANNA
Justin PIERSON
Christoph Rader
Christopher THEILE
Zhi Xiang Voo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
University of Florida Research Foundation Inc
Original Assignee
University of Florida
Alnylam Pharmaceuticals Inc
University of Florida Research Foundation Inc
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Application filed by University of Florida, Alnylam Pharmaceuticals Inc, University of Florida Research Foundation Inc filed Critical University of Florida
Publication of AU2020295485A1 publication Critical patent/AU2020295485A1/en
Assigned to UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., ALNYLAM PHARMACEUTICALS, INC. reassignment UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. Request for Assignment Assignors: ALNYLAM PHARMACEUTICALS, INC., THE SCRIPPS RESEARCH INSTITUTE
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AU2020295485A 2019-06-21 2020-06-18 Structurally defined siRNA-dual variable domain immunoglobulin conjugates Pending AU2020295485A1 (en)

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US201962864755P 2019-06-21 2019-06-21
US62/864,755 2019-06-21
PCT/US2020/038475 WO2020257483A1 (en) 2019-06-21 2020-06-18 Structurally defined sirna-dual variable domain immunoglobulin conjugates

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EP (1) EP3986475A4 (https=)
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AU (1) AU2020295485A1 (https=)
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JP4851940B2 (ja) * 2004-11-19 2012-01-11 宮城県 がんまたは糖尿病治療のための医薬組成物
US20110223665A1 (en) * 2008-07-25 2011-09-15 Alnylam Pharmaceuticals, Inc. ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND
IL316808A (en) * 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
CN108025071B (zh) * 2015-09-17 2022-11-01 斯克利普斯研究院 双重可变结构域免疫缀合物及其用途
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