AU2020291936A1 - Dibenzylamines as amino acid transport inhibitors - Google Patents

Info

Publication number

AU2020291936A1

AU2020291936A1 AU2020291936A AU2020291936A AU2020291936A1 AU 2020291936 A1 AU2020291936 A1 AU 2020291936A1 AU 2020291936 A AU2020291936 A AU 2020291936A AU 2020291936 A AU2020291936 A AU 2020291936A AU 2020291936 A1 AU2020291936 A1 AU 2020291936A1

Authority

AU

Australia

Prior art keywords

amino

compound

benzyl

cancer

pharmaceutically acceptable

Prior art date

2019-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
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• 239000003112 inhibitor Substances 0.000 title abstract description 44
• 150000001413 amino acids Chemical class 0.000 title description 27
• BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical class C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 362
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 231
• 201000011510 cancer Diseases 0.000 claims abstract description 181
• -1 cyano, hydroxy, amino Chemical group 0.000 claims description 133
• 238000000034 method Methods 0.000 claims description 105
• 150000003839 salts Chemical class 0.000 claims description 94
• 239000012453 solvate Substances 0.000 claims description 90
• 239000003814 drug Substances 0.000 claims description 68
• 229910052739 hydrogen Inorganic materials 0.000 claims description 46
• 239000001257 hydrogen Substances 0.000 claims description 46
• 230000035772 mutation Effects 0.000 claims description 45
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 38
• 229940124597 therapeutic agent Drugs 0.000 claims description 37
• 239000012472 biological sample Substances 0.000 claims description 35
• 238000011282 treatment Methods 0.000 claims description 35
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 33
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 33
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 28
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 27
• 230000004797 therapeutic response Effects 0.000 claims description 27
• 239000003795 chemical substances by application Substances 0.000 claims description 25
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 18
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
• 239000008194 pharmaceutical composition Substances 0.000 claims description 18
• 230000001225 therapeutic effect Effects 0.000 claims description 18
• 230000002489 hematologic effect Effects 0.000 claims description 16
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 13
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 12
• 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 8
• 239000003937 drug carrier Substances 0.000 claims description 8
• 238000004519 manufacturing process Methods 0.000 claims description 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
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• 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
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• 230000000069 prophylactic effect Effects 0.000 claims description 3
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