AU2020287620B2 - Compositions and methods relating to erythrocytes with adhered particles - Google Patents

Compositions and methods relating to erythrocytes with adhered particles

Info

Publication number
AU2020287620B2
AU2020287620B2 AU2020287620A AU2020287620A AU2020287620B2 AU 2020287620 B2 AU2020287620 B2 AU 2020287620B2 AU 2020287620 A AU2020287620 A AU 2020287620A AU 2020287620 A AU2020287620 A AU 2020287620A AU 2020287620 B2 AU2020287620 B2 AU 2020287620B2
Authority
AU
Australia
Prior art keywords
composition
plga
cell
erythrocytes
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020287620A
Other languages
English (en)
Other versions
AU2020287620A1 (en
Inventor
Samir Mitragotri
Anvay Ashish UKIDVE
Zongmin ZHAO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of AU2020287620A1 publication Critical patent/AU2020287620A1/en
Application granted granted Critical
Publication of AU2020287620B2 publication Critical patent/AU2020287620B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A61K47/6937—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol the polymer being PLGA, PLA or polyglycolic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2020287620A 2019-06-07 2020-06-04 Compositions and methods relating to erythrocytes with adhered particles Active AU2020287620B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962858478P 2019-06-07 2019-06-07
US62/858,478 2019-06-07
PCT/US2020/036040 WO2020247576A1 (en) 2019-06-07 2020-06-04 Compositions and methods relating to erythrocytes with adhered particles

Publications (2)

Publication Number Publication Date
AU2020287620A1 AU2020287620A1 (en) 2022-01-06
AU2020287620B2 true AU2020287620B2 (en) 2025-12-18

Family

ID=73652929

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020287620A Active AU2020287620B2 (en) 2019-06-07 2020-06-04 Compositions and methods relating to erythrocytes with adhered particles

Country Status (8)

Country Link
US (1) US20220323603A1 (https=)
EP (1) EP3979994A4 (https=)
JP (1) JP7561146B2 (https=)
CN (1) CN114222564A (https=)
AU (1) AU2020287620B2 (https=)
CA (1) CA3140681A1 (https=)
IL (1) IL288743B2 (https=)
WO (1) WO2020247576A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3180060A1 (en) * 2020-05-29 2021-12-02 Zongmin ZHAO Living cells engineered with polyphenol-functionalized biologically active nanocomplexes
WO2023288046A1 (en) 2021-07-15 2023-01-19 President And Fellows Of Harvard College Compositions and methods relating to cells with adhered particles
CN118871571A (zh) * 2022-03-11 2024-10-29 西湖生物医药科技(上海)有限公司 一种靶向pd-1的工程化红细胞
WO2026046110A1 (zh) * 2024-08-26 2026-03-05 西湖生物医药科技(杭州)有限公司 一种基于工程化红细胞的新型药物递送系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032970A2 (en) * 2002-10-10 2004-04-22 Samir Mitragotri Carriers attached to blood cells

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998393B2 (en) * 2000-06-23 2006-02-14 Biopharm Solutions, Inc. Aquespheres, their preparation and uses thereof
WO2007084460A2 (en) * 2006-01-18 2007-07-26 Qps, Llc Pharmaceutical compositions with enhanced stability
EP2714017B1 (en) 2011-06-02 2018-08-01 The Regents of The University of California Membrane encapsulated nanoparticles and method of use
US11400114B2 (en) * 2016-03-15 2022-08-02 Massachusetts Institute Of Technology Synthetically functionalized living cells for targeted drug delivery
JP6888239B2 (ja) 2017-06-28 2021-06-16 株式会社 ＳＥＮＴＡＮ Ｐｈａｒｍａ 腫瘍治療用腫瘍免疫活性促進剤及び腫瘍治療用医薬組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004032970A2 (en) * 2002-10-10 2004-04-22 Samir Mitragotri Carriers attached to blood cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRENNER JACOB S., PAN DANIEL C., MYERSON JACOB W., MARCOS-CONTRERAS OSCAR A., VILLA CARLOS H., PATEL PRIYAL, HEKIERSKI HUGH, CHATT: "Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude", NATURE COMMUNICATIONS, vol. 9, no. 1, 1 December 2018 (2018-12-01), XP055843924, DOI: 10.1038/s41467-018-05079-7 *
ZELEPUKIN I. V., YAREMENKO A. V., SHIPUNOVA V. O., BABENYSHEV A. V., BALALAEVA I. V., NIKITIN P. I., DEYEV S. M., NIKITIN M. P.: "Nanoparticle-based drug delivery via RBC-hitchhiking for the inhibition of lung metastases growth", NANOSCALE, ROYAL SOCIETY OF CHEMISTRY, vol. 11, no. 4, 23 January 2019 (2019-01-23), pages 1636 - 1646, XP093057906, ISSN: 2040-3364, DOI: 10.1039/C8NR07730D *

Also Published As

Publication number Publication date
JP7561146B2 (ja) 2024-10-03
EP3979994A1 (en) 2022-04-13
IL288743B1 (en) 2024-10-01
IL288743A (en) 2022-02-01
EP3979994A4 (en) 2023-08-09
US20220323603A1 (en) 2022-10-13
AU2020287620A1 (en) 2022-01-06
IL288743B2 (en) 2025-02-01
CN114222564A (zh) 2022-03-22
CA3140681A1 (en) 2020-12-10
WO2020247576A1 (en) 2020-12-10
JP2022534796A (ja) 2022-08-03

Similar Documents

Publication Publication Date Title
AU2020287620B2 (en) Compositions and methods relating to erythrocytes with adhered particles
JP7208492B2 (ja) 併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法
US10314854B2 (en) Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
US20230414540A1 (en) Combination of immunotherapy with local chemotherapy for the treatment of malignancies
JP2020183413A (ja) Ｔｅｃファミリーキナーゼ阻害剤アジュバント療法
KR20210013184A (ko) 비스플루오로알킬-1,4-벤조디아제피논 화합물과 면역요법제를 포함하는 조성물 및 이의 사용 방법
US12383575B2 (en) Polyinosinic—polycytidylic acid compositions
US20220000872A1 (en) Method of enhancing immune-based therapy
CN105828834A (zh) 检查点抑制剂和治疗剂的组合以治疗癌症
JP7061134B2 (ja) 薬剤負荷ナノ粒子が表面に結合したｃａｒ ｔ細胞の養子移入およびその使用
JP7330994B2 (ja) 治療用ナノ生物学的組成物による訓練免疫の促進
BR112021001858A2 (pt) uso de partículas negativamente carregadas em combinação com uma terapia de câncer para o tratamento de câncer ou de uma doença proliferativa
CN110769898A (zh) 使用嵌合抗原受体工程化自然杀伤细胞作为化学治疗药物运载体的联合癌症疗法
WO2018187259A1 (en) Methods and compositions for stimulating the immune system
US20230399404A1 (en) Sustained antibody and immunotherapeutic delivery to cervical lymph nodes
RU2794261C2 (ru) Иммуномодифицирующие частицы для лечения рака
Makkouk Biodegradable microparticles for in situ immunization against cancer
HK40015392A (en) Combination cancer therapy using chimeric antigen receptor engineered natural killer cells as chemotherapeutic drug carriers

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)