AU2020271280B2 - Method for continuously producing an active ingredient granulate - Google Patents

Method for continuously producing an active ingredient granulate

Info

Publication number
AU2020271280B2
AU2020271280B2 AU2020271280A AU2020271280A AU2020271280B2 AU 2020271280 B2 AU2020271280 B2 AU 2020271280B2 AU 2020271280 A AU2020271280 A AU 2020271280A AU 2020271280 A AU2020271280 A AU 2020271280A AU 2020271280 B2 AU2020271280 B2 AU 2020271280B2
Authority
AU
Australia
Prior art keywords
particles
active
thethe
active ingredient
ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020271280A
Other languages
English (en)
Other versions
AU2020271280A1 (en
Inventor
Annette Grave
Michael Jacob
Reinhard Nowak
Norbert Pöllinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADD Advanced Drug Delivery Technologies AG
Original Assignee
ADD Advanced Drug Delivery Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADD Advanced Drug Delivery Technologies AG filed Critical ADD Advanced Drug Delivery Technologies AG
Publication of AU2020271280A1 publication Critical patent/AU2020271280A1/en
Application granted granted Critical
Publication of AU2020271280B2 publication Critical patent/AU2020271280B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
AU2020271280A 2019-04-11 2020-04-09 Method for continuously producing an active ingredient granulate Active AU2020271280B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168685.6 2019-04-11
EP19168685.6A EP3721871A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
PCT/EP2020/060278 WO2020208202A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (2)

Publication Number Publication Date
AU2020271280A1 AU2020271280A1 (en) 2021-12-09
AU2020271280B2 true AU2020271280B2 (en) 2025-07-24

Family

ID=66105207

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020271280A Active AU2020271280B2 (en) 2019-04-11 2020-04-09 Method for continuously producing an active ingredient granulate

Country Status (13)

Country Link
US (1) US12551443B2 (enExample)
EP (2) EP3721871A1 (enExample)
JP (1) JP7602483B2 (enExample)
CN (2) CN114302711A (enExample)
AU (1) AU2020271280B2 (enExample)
BR (1) BR112021020282A2 (enExample)
CA (1) CA3144742A1 (enExample)
DK (1) DK3952844T3 (enExample)
ES (1) ES3053040T3 (enExample)
IL (1) IL287121B2 (enExample)
PL (1) PL3952844T3 (enExample)
PT (1) PT3952844T (enExample)
WO (1) WO2020208202A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102024107710A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Verfahren zur Herstellung von Tabletten
DE102024107712A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Vorrichtung zur Herstellung von Tabletten

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159252A (en) * 1995-04-21 2000-12-12 Degussa-Hus Aktiengesellschaft Process and device for producing granulates by fluidized bed spray granulation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1088357C (zh) 1994-01-14 2002-07-31 埃迪克埃迪法姆药品实验室 5－硝基咪唑衍生物微粒
CN1114647C (zh) * 1998-07-21 2003-07-16 范蒂科股份公司 松散的颗粒材料
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
EP1345968A2 (en) * 2000-12-28 2003-09-24 Altus Biologics Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
KR100592512B1 (ko) * 2002-11-22 2006-07-03 서울약품공업(주) 탐술로신 또는 약제학적으로 허용되는 이의 염을활성성분으로 하는 서방성 배뇨장애 치료제
DE10322062A1 (de) * 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
US8231938B2 (en) 2003-06-11 2012-07-31 Glatt Ingenieurtechnik Gmbh Method for production of enzyme granules and enzyme granules produced thus
DE102005037630A1 (de) * 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung
DE102007012105A1 (de) * 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
EP2735307A1 (de) 2008-12-08 2014-05-28 Ratiopharm GmbH Kompaktiertes Moxifloxacin
WO2010106555A2 (en) 2009-03-17 2010-09-23 Shantilal, Doshi, Bimalkumar Directly compressible pre-granulated cellulose ether polymer and process for preparing the same
JP5922310B2 (ja) * 2013-07-25 2016-05-24 株式会社三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
EP3721870A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159252A (en) * 1995-04-21 2000-12-12 Degussa-Hus Aktiengesellschaft Process and device for producing granulates by fluidized bed spray granulation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRISTOPH NEUGEBAUER ET AL: "Influence of Thermal Conditions on Particle Properties in Fluidized Bed Layering Granulation", PROCESSES, vol. 6, no. 12, 22 November 2018 (2018-11-22), pages 235, XP055621782, DOI: 10.3390/pr6120235 *
HEINRICH S ET AL: "Analysis of the start-up process in continuous fluidized bed spray granulation by population balance modelling", CHEM ENG SCI, vol. 57 (20), 2002-10-01, pages 4369 - 4390, DOI: 10.1016/S0009-2509(02)00352-4 *

Also Published As

Publication number Publication date
IL287121B2 (en) 2026-05-01
BR112021020282A2 (pt) 2021-12-14
JP2022528783A (ja) 2022-06-15
WO2020208202A1 (de) 2020-10-15
US12551443B2 (en) 2026-02-17
DK3952844T3 (da) 2025-11-17
EP3952844A1 (de) 2022-02-16
US20220280432A1 (en) 2022-09-08
CA3144742A1 (en) 2020-10-15
ES3053040T3 (en) 2026-01-16
EP3952844B1 (de) 2025-08-27
IL287121A (en) 2022-01-01
CN114302711A (zh) 2022-04-08
AU2020271280A1 (en) 2021-12-09
CN118649138A (zh) 2024-09-17
IL287121B1 (en) 2026-01-01
JP7602483B2 (ja) 2024-12-18
PT3952844T (pt) 2025-11-21
PL3952844T3 (pl) 2026-01-19
EP3721871A1 (de) 2020-10-14

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