AU2020213695A1 - A microfluidic device and a method for provision of double emulsion droplets - Google Patents

A microfluidic device and a method for provision of double emulsion droplets Download PDF

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Publication number
AU2020213695A1
AU2020213695A1 AU2020213695A AU2020213695A AU2020213695A1 AU 2020213695 A1 AU2020213695 A1 AU 2020213695A1 AU 2020213695 A AU2020213695 A AU 2020213695A AU 2020213695 A AU2020213695 A AU 2020213695A AU 2020213695 A1 AU2020213695 A1 AU 2020213695A1
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AU
Australia
Prior art keywords
conduit
fluid
microfluidic
container
microfluidic device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2020213695A
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English (en)
Inventor
Solène CHERRE
Thomas Kvist
Esben Bjørn MADSEN
Marie Just Mikkelsen
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Samplix ApS
Original Assignee
Samplix ApS
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Filing date
Publication date
Application filed by Samplix ApS filed Critical Samplix ApS
Publication of AU2020213695A1 publication Critical patent/AU2020213695A1/en
Pending legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/813—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles mixing simultaneously in two or more mixing receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
AU2020213695A 2019-01-31 2020-01-31 A microfluidic device and a method for provision of double emulsion droplets Pending AU2020213695A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19154948 2019-01-31
EP19154948.4 2019-01-31
EP19168733 2019-04-11
EP19168733.4 2019-04-11
PCT/EP2020/052400 WO2020157262A1 (en) 2019-01-31 2020-01-31 A microfluidic device and a method for provision of double emulsion droplets

Publications (1)

Publication Number Publication Date
AU2020213695A1 true AU2020213695A1 (en) 2021-07-29

Family

ID=69190813

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020213695A Pending AU2020213695A1 (en) 2019-01-31 2020-01-31 A microfluidic device and a method for provision of double emulsion droplets

Country Status (7)

Country Link
US (1) US20220105516A1 (de)
EP (1) EP3917654A1 (de)
JP (1) JP7231748B2 (de)
CN (1) CN113710352B (de)
AU (1) AU2020213695A1 (de)
CA (1) CA3127163A1 (de)
WO (1) WO2020157262A1 (de)

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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EP1447127B1 (de) 2001-02-23 2007-07-04 Japan Science and Technology Agency Vorrichtung zum Erzeugen von Emulsionen
JP4306243B2 (ja) * 2002-12-17 2009-07-29 東ソー株式会社 粒子製造方法
US20050064209A1 (en) * 2004-02-17 2005-03-24 Daniel Haines Low-fluorescent, chemically durable hydrophobic patterned substrates for the attachment of biomolecules
US20060057209A1 (en) * 2004-09-16 2006-03-16 Predicant Biosciences, Inc. Methods, compositions and devices, including microfluidic devices, comprising coated hydrophobic surfaces
EP2248578B1 (de) * 2005-03-04 2012-06-06 President and Fellows of Harvard College Verfahren zur Bildung mehrerer Emulsionen
EP2271581A4 (de) * 2008-03-28 2014-09-03 Harvard College Mikrofluidkanäle enthaltende flächen mit gesteuerten benetzungseigenschaften
US9492797B2 (en) * 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
GB2477053B (en) * 2008-09-23 2013-11-13 Quantalife Inc Droplet-based assay system
WO2011120024A1 (en) * 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
DE102009024048B3 (de) * 2009-05-08 2010-08-19 Institut für Bioprozess- und Analysenmesstechnik e.V. Montier- und demontierbares Mikrofluidiksystem und Verfahren zur Flutung des Systems
IN2012DN01972A (de) * 2009-09-02 2015-08-21 Harvard College
CN102574078B (zh) * 2009-09-02 2016-05-18 哈佛学院院长等 使用喷射和其它技术产生的多重乳液
WO2011106315A1 (en) * 2010-02-23 2011-09-01 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
WO2012008497A1 (ja) * 2010-07-13 2012-01-19 国立大学法人東京工業大学 微小液滴の製造装置
WO2012047802A2 (en) * 2010-10-01 2012-04-12 The Johns Hopkins University Systems and methods for high-throughput microfluidic bead production
JP5922139B2 (ja) * 2010-11-01 2016-05-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド エマルジョンを形成するためのシステム
JP6122843B2 (ja) 2011-05-23 2017-04-26 プレジデント アンド フェローズ オブ ハーバード カレッジ 多重エマルジョンを含むエマルジョンの制御
WO2014145760A1 (en) * 2013-03-15 2014-09-18 Bio-Rad Laboratories, Inc. Droplet generator with collection tube
JP6127344B2 (ja) * 2013-03-28 2017-05-17 パナソニックＩｐマネジメント株式会社 信号生成回路
CN114534806B (zh) * 2014-04-10 2024-03-29 10X基因组学有限公司 用于封装和分割试剂的流体装置、系统和方法及其应用
WO2015160919A1 (en) * 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
JP6829202B2 (ja) * 2015-02-04 2021-02-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多重エマルジョン核酸増幅
EP3429750A1 (de) * 2016-03-15 2019-01-23 Evonik Röhm GmbH Mikrofluidvorrichtungen mit einem mikrokanal mit hydrophiler beschichtung
KR102371209B1 (ko) * 2017-03-24 2022-03-07 (주)아모레퍼시픽 순간 유화 화장품 제조 장치 및 제조 방법
BR112019019347A2 (pt) * 2017-03-29 2020-04-14 Univ Cornell dispositivos, processos e sistemas para determinação da sequência de ácido nucleico, expressão, número de cópias ou mudanças de metilação usando reações combinadas de nuclease, ligase, polimerase e sequenciamento
EP3391958B1 (de) * 2017-04-19 2020-08-12 The Procter & Gamble Company Verfahren zur herstellung von oberflächenbeschichteten wasserabsorbierenden polymerpartikeln in einer mikrofluidischen vorrichtung
CN108545692B (zh) * 2018-03-27 2020-12-08 浙江大学 一种通道内壁涂覆聚对二甲苯的微流控芯片制作方法

Also Published As

Publication number Publication date
US20220105516A1 (en) 2022-04-07
WO2020157262A1 (en) 2020-08-06
CA3127163A1 (en) 2020-08-06
CN113710352A (zh) 2021-11-26
JP7231748B2 (ja) 2023-03-01
CN113710352B (zh) 2024-03-26
JP2022519200A (ja) 2022-03-22
EP3917654A1 (de) 2021-12-08

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