AU2020205042B2 - An A3 adenosine receptor ligand for use for achieving a fat loss effect - Google Patents

An A3 adenosine receptor ligand for use for achieving a fat loss effect Download PDF

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Publication number
AU2020205042B2
AU2020205042B2 AU2020205042A AU2020205042A AU2020205042B2 AU 2020205042 B2 AU2020205042 B2 AU 2020205042B2 AU 2020205042 A AU2020205042 A AU 2020205042A AU 2020205042 A AU2020205042 A AU 2020205042A AU 2020205042 B2 AU2020205042 B2 AU 2020205042B2
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AU
Australia
Prior art keywords
ligand
subject
a3ar
amine
quinolin
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Active
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AU2020205042A
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English (en)
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AU2020205042A1 (en
Inventor
Shira Cohen
Motti FARBSTEIN
Pnina Fishman
Inbal ITZHAK
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Can Fite Biopharma Ltd
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Can Fite Biopharma Ltd
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Publication of AU2020205042A1 publication Critical patent/AU2020205042A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2020205042A 2019-01-06 2020-01-05 An A3 adenosine receptor ligand for use for achieving a fat loss effect Active AU2020205042B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL264112A IL264112A (en) 2019-01-06 2019-01-06 An a3 adenosine receptor ligand for use for reducing level of adipocytes
IL264112 2019-01-06
PCT/IL2020/050011 WO2020141535A1 (en) 2019-01-06 2020-01-05 An a3 adenosine receptor ligand for use for achieving a fat loss effect

Publications (2)

Publication Number Publication Date
AU2020205042A1 AU2020205042A1 (en) 2021-07-15
AU2020205042B2 true AU2020205042B2 (en) 2024-10-10

Family

ID=65656120

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020205042A Active AU2020205042B2 (en) 2019-01-06 2020-01-05 An A3 adenosine receptor ligand for use for achieving a fat loss effect

Country Status (11)

Country Link
US (1) US12213990B2 (enExample)
EP (1) EP3906034A1 (enExample)
JP (3) JP2022517753A (enExample)
KR (1) KR20210113279A (enExample)
CN (1) CN113543790A (enExample)
AU (1) AU2020205042B2 (enExample)
BR (1) BR112021013084A2 (enExample)
CA (1) CA3126002A1 (enExample)
IL (2) IL264112A (enExample)
MX (1) MX2021008172A (enExample)
WO (1) WO2020141535A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202300014340A1 (it) * 2023-07-10 2025-01-10 Consiglio Nazionale Ricerche Trattamento di malattie associate alla disfunzione del gene ocrl.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017090036A1 (en) * 2015-11-23 2017-06-01 Can-Fite Biopharma Ltd. An a3 adenosine receptor ligand for use in treating ectopic fat accumulation
KR101881441B1 (ko) * 2017-01-20 2018-07-24 서울대학교산학협력단 다중 약리단 특성에 기반한 비정상적 아디포넥틴 관련 질환 치료용 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443836A (en) 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5688774A (en) 1993-07-13 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
US5773423A (en) 1993-07-13 1998-06-30 The United States Of America As Represented By The Department Of Health And Human Services A3 adenosine receptor agonists
AU1399297A (en) 1996-01-24 1997-08-20 Sumitomo Chemical Company, Limited Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production
CA2296485A1 (en) 1997-07-29 1999-02-11 Medco Research, Inc. N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators
US6048865A (en) 1997-07-29 2000-04-11 Medco Research, Inc. N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator
AU1363699A (en) 1997-10-23 1999-05-10 National Institute Of Health Methods for reducing ischemic injury of the heart via the sequential administ ration of monophosphoryl lipid a and adenosine receptor agents
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
DK1983990T3 (da) 2006-01-26 2011-07-11 Us Gov Health & Human Serv Allosteriske A3-adenosin-receptormodulatorer
WO2012027695A1 (en) * 2010-08-26 2012-03-01 Northeastern University Methods and compositions for preventing or treating obesity
WO2013111132A1 (en) 2012-01-23 2013-08-01 Can-Fite Biopharma Ltd. Treatment of liver conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017090036A1 (en) * 2015-11-23 2017-06-01 Can-Fite Biopharma Ltd. An a3 adenosine receptor ligand for use in treating ectopic fat accumulation
KR101881441B1 (ko) * 2017-01-20 2018-07-24 서울대학교산학협력단 다중 약리단 특성에 기반한 비정상적 아디포넥틴 관련 질환 치료용 조성물

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KR 101881441 B1 (Machine translation reviewed) *

Also Published As

Publication number Publication date
EP3906034A1 (en) 2021-11-10
JP2022517753A (ja) 2022-03-10
JP2025098147A (ja) 2025-07-01
IL264112A (en) 2020-07-30
JP2023100928A (ja) 2023-07-19
US20220079968A1 (en) 2022-03-17
AU2020205042A1 (en) 2021-07-15
CN113543790A (zh) 2021-10-22
WO2020141535A1 (en) 2020-07-09
BR112021013084A2 (pt) 2021-09-21
US12213990B2 (en) 2025-02-04
MX2021008172A (es) 2021-08-11
IL284463A (en) 2021-08-31
KR20210113279A (ko) 2021-09-15
CA3126002A1 (en) 2020-07-09
JP7894175B2 (ja) 2026-07-23
IL284463B1 (en) 2026-04-01
IL284463B2 (en) 2026-08-01

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