AU2019365102A1 - Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions - Google Patents

Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions Download PDF

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Publication number
AU2019365102A1
AU2019365102A1 AU2019365102A AU2019365102A AU2019365102A1 AU 2019365102 A1 AU2019365102 A1 AU 2019365102A1 AU 2019365102 A AU2019365102 A AU 2019365102A AU 2019365102 A AU2019365102 A AU 2019365102A AU 2019365102 A1 AU2019365102 A1 AU 2019365102A1
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biopharmaceutical
analytical measurement
query point
biopharmaceutical process
observation
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Abandoned
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AU2019365102A
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English (en)
Inventor
Aditya TULSYAN
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Amgen Inc
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Amgen Inc
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Publication of AU2019365102A1 publication Critical patent/AU2019365102A1/en
Priority to AU2025205401A priority Critical patent/AU2025205401A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N2021/8411—Application to online plant, process monitoring
    • G01N2021/8416—Application to online plant, process monitoring and process controlling, not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/129—Using chemometrical methods

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Software Systems (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Data Mining & Analysis (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Computing Systems (AREA)
  • Mathematical Physics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Computational Linguistics (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
AU2019365102A 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions Abandoned AU2019365102A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025205401A AU2025205401A1 (en) 2018-10-23 2025-07-11 Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862749359P 2018-10-23 2018-10-23
US62/749,359 2018-10-23
US201962833044P 2019-04-12 2019-04-12
US62/833,044 2019-04-12
US201962864565P 2019-06-21 2019-06-21
US62/864,565 2019-06-21
PCT/US2019/057513 WO2020086635A1 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of raman spectroscopic models for real-time predictions

Related Child Applications (1)

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AU2025205401A Division AU2025205401A1 (en) 2018-10-23 2025-07-11 Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions

Publications (1)

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AU2019365102A1 true AU2019365102A1 (en) 2021-04-29

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AU2019365102A Abandoned AU2019365102A1 (en) 2018-10-23 2019-10-23 Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions
AU2025205401A Pending AU2025205401A1 (en) 2018-10-23 2025-07-11 Automatic calibration and automatic maintenance of Raman spectroscopic models for real-time predictions

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US (1) US20220128474A1 (https=)
EP (1) EP3870957B1 (https=)
JP (1) JP7601760B2 (https=)
KR (1) KR20210078531A (https=)
CN (1) CN112912716B (https=)
AU (2) AU2019365102A1 (https=)
CA (1) CA3115296A1 (https=)
CL (1) CL2021001024A1 (https=)
DK (1) DK3870957T3 (https=)
ES (1) ES3041713T3 (https=)
FI (1) FI3870957T3 (https=)
HU (1) HUE072452T2 (https=)
IL (1) IL281977B2 (https=)
LT (1) LT3870957T (https=)
MX (1) MX2021004510A (https=)
PL (1) PL3870957T3 (https=)
PT (1) PT3870957T (https=)
SG (1) SG11202103232WA (https=)
SI (1) SI3870957T1 (https=)
TW (1) TWI844570B (https=)
WO (1) WO2020086635A1 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN114207593B (zh) * 2019-06-10 2025-10-21 沃特世科技爱尔兰有限公司 用于分析仪器性能诊断的技术
WO2021108453A1 (en) * 2019-11-26 2021-06-03 Thermo Finnigan Llc Remote monitoring, troubleshooting and service scheduling of analytical apparatuses
CN116457453A (zh) * 2020-10-01 2023-07-18 美国安进公司 细胞培养的预测建模和控制
US20220138557A1 (en) * 2020-11-04 2022-05-05 Adobe Inc. Deep Hybrid Graph-Based Forecasting Systems
US20210117841A1 (en) * 2020-12-23 2021-04-22 Intel Corporation Methods, apparatus, and articles of manufacture to improve automated machine learning
DE102021100531B3 (de) * 2021-01-13 2022-03-31 BioThera Institut GmbH Apparatur zum Steuern eines Prozesses sowie zugehöriges Steuerungsverfahren
JP2024525133A (ja) * 2021-06-09 2024-07-10 アムジエン・インコーポレーテツド 細胞培養物の血中血球容積の評価
WO2022269464A1 (en) * 2021-06-20 2022-12-29 The State Of Israel, Ministry Of Agriculture & Rural Development Agricultural Research Organization (Aro) Raman spectroscopy method and system for monitoring invasive species in algal bioreactors
EP4390379A4 (en) * 2021-09-30 2025-01-01 FUJIFILM Corporation LEARNING DATA ACQUISITION METHOD, LEARNING DATA ACQUISITION SYSTEM, SOFT SENSOR CONSTRUCTION METHOD, SOFT SENSOR, AND LEARNING DATA
JP2025500732A (ja) 2021-10-27 2025-01-15 アムジエン・インコーポレーテツド 分光法を使用して薬剤を監視するための深層学習ベースの予測
JPWO2023090015A1 (https=) * 2021-11-22 2023-05-25
JP7783091B2 (ja) * 2022-02-25 2025-12-09 株式会社日立製作所 評価システム及び評価方法
TW202346567A (zh) * 2022-03-01 2023-12-01 美商安進公司 用於控制細胞培養之混合預測建模
CN115308102B (zh) * 2022-05-19 2025-07-01 芬欧汇川(中国)有限公司 纸张透气度测量方法以及纸张透气度测量系统
US20240044801A1 (en) * 2022-07-26 2024-02-08 Thermo Scientific Portable Analytical Instruments Inc. Autochemometric scientific instrument support systems
CA3265250A1 (en) * 2022-08-29 2024-03-07 Amgen Inc. PREDICTIVE MODEL FOR EVALUATING PROCESSING TIME IMPACTS
EP4581349A1 (en) * 2022-08-29 2025-07-09 Büchi Labortechnik AG Methods for providing a predictive model for spectroscopy and calibrating a spectroscopic device
CA3265356A1 (en) 2022-09-14 2024-03-21 Amgen Inc. JUST-IN-TIME LEARNING WITH VARIATIONAL AUTOCODER FOR MONITORING AND/OR CONTROL OF CELL CULTURE PROCESSES
JP2026502096A (ja) * 2022-12-12 2026-01-21 ジェネンテック， インコーポレイテッド 限外濾過／透析濾過（ｕｆ／ｄｆ）コンディショニングおよび希釈プロセスのリアルタイム自動モニタリングと制御
WO2024188962A1 (en) * 2023-03-14 2024-09-19 Katholieke Universiteit Leuven Spectrum prediction methods for chemical processes
WO2024202620A1 (ja) 2023-03-31 2024-10-03 富士フイルム株式会社 品質監視装置、品質監視装置の作動方法、および品質監視装置の作動プログラム
KR20250023079A (ko) 2023-08-09 2025-02-18 주식회사 엘지화학 발효공정의 생성량 예측 시스템 및 방법
CN117571684A (zh) * 2023-11-20 2024-02-20 无锡药明生物技术股份有限公司 细胞培养液代谢物浓度确定方法、装置、设备和介质
WO2025114830A1 (en) * 2023-11-27 2025-06-05 Avant Meats Company Limited Control system and method for a perpetual automated bioprocessing system
WO2025132566A1 (en) 2023-12-21 2025-06-26 Boehringer Ingelheim International Gmbh Measuring arrangement and method for analyzing a fluidic sample
CN118819056B (zh) * 2024-09-19 2024-12-31 天津医学高等专科学校(天津市护士学校) 一种黄芩细胞悬浮培养优化控制系统
CN118820281B (zh) * 2024-09-19 2024-12-31 之江实验室 光谱数据库查询模型构建方法以及光谱数据库查询方法
EP4715492A1 (en) * 2024-09-20 2026-03-25 Sartorius Stedim Data Analytics AB Monitoring and/or controlling a chemical and/or biological process
CN119223939B (zh) * 2024-11-28 2025-04-01 合肥金星智控科技股份有限公司 基于libs的物料检测模型的自适应校准方法及装置

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319494B1 (en) 1990-12-14 2001-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5862060A (en) * 1996-11-22 1999-01-19 Uop Llc Maintenance of process control by statistical analysis of product optical spectrum
US7112324B1 (en) 1998-04-21 2006-09-26 Micromet Ag CD 19×CD3 specific polypeptides and uses thereof
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
EP1558374A2 (en) * 2002-10-28 2005-08-03 BP Corporation North America Inc. Process and method for chemical manufacturing using transformation of on-line instrumentation data
BR0317538A (pt) 2002-12-20 2005-11-29 Amgen Inc Agente ligante, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, composição farmacêutica, e, métodos de inibir a atividade de miostatina, de aumentar a massa muscular magra e a razão de massa muscular magra para gordura, de tratar uma doença de emaciação muscular e um distúrbio metabólico relacionado com miostatina em um indivìduo, de detectar e medir miostatina em uma amostra, e, de diagnosticar um distúrbio relacionado com miostatina em um indivìduo
US8688384B2 (en) * 2003-05-12 2014-04-01 River Diagnostics B.V. Automated characterization and classification of microorganisms
MXPA06004035A (es) 2003-10-16 2006-08-31 Micromet Ag Aglutinantes cd3 de-inmunizados multi-especificos.
EP1902356A4 (en) 2005-06-09 2009-08-19 Chemimage Corp CRIMINOLOGICAL INTEGRATED SEARCH TECHNOLOGY
NZ554258A (en) 2007-03-29 2009-01-31 Khipu Systems Ltd Predictive model implementation system and methodology
RS53008B2 (sr) 2007-04-03 2022-12-30 Amgen Res Munich Gmbh Interspecijski specifičan cd3-epsilon vezujući domen
US7961312B2 (en) * 2007-08-13 2011-06-14 C8 Medisensors Inc. Calibrated analyte concentration measurements in mixtures
US8311955B2 (en) 2007-10-30 2012-11-13 Exxonmobil Research And Engineering Company Bootstrap method for oil property prediction
EP2215455B1 (en) 2007-11-02 2014-03-05 Ceres, Inc. A method for formulating an NIR model used in biomass processing
US8725667B2 (en) * 2008-03-08 2014-05-13 Tokyo Electron Limited Method and system for detection of tool performance degradation and mismatch
GB2466442A (en) * 2008-12-18 2010-06-23 Dublin Inst Of Technology A system to analyze a sample on a slide using Raman spectroscopy on an identified area of interest
CN101825567A (zh) * 2010-04-02 2010-09-08 南开大学 一种近红外光谱和拉曼光谱波长的筛选方法
MX353382B (es) 2012-03-01 2018-01-10 Amgen Res Munich Gmbh Moleculas de union polipeptido de larga duracion.
EP2648133A1 (fr) 2012-04-04 2013-10-09 Biomerieux Identification de microorganismes par spectrometrie et classification structurée
US20130311136A1 (en) 2012-05-18 2013-11-21 Mustard Tree Instruments, Llc Rule-Based Sample Verification and Chemical Monitoring Methodology
GB2513343A (en) * 2013-04-23 2014-10-29 Univ Singapore Methods related to instrument-independent measurements for quantitative analysis of fiber-optic Raman spectroscopy
US20140114676A1 (en) * 2012-10-23 2014-04-24 Theranos, Inc. Drug Monitoring and Regulation Systems and Methods
US11634502B2 (en) 2013-03-15 2023-04-25 Amgen Inc. Heterodimeric bispecific antibodies
PL2970449T3 (pl) 2013-03-15 2020-04-30 Amgen Research (Munich) Gmbh Jednołańcuchowe cząsteczki wiążące zawierające N-końcowy ABP
US20140302037A1 (en) 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
US20140308285A1 (en) 2013-03-15 2014-10-16 Amgen Inc. Heterodimeric bispecific antibodies
CN104215623B (zh) * 2013-05-31 2018-09-25 欧普图斯(苏州)光学纳米科技有限公司 面向多行业检测的激光拉曼光谱智能化辨识方法及系统
US20160257748A1 (en) 2013-09-25 2016-09-08 Amgen Inc. V-c-fc-v-c antibody
EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
EP3303561A2 (en) * 2015-05-29 2018-04-11 Biogen MA Inc. Cell culture methods and systems
WO2017015568A1 (en) * 2015-07-22 2017-01-26 Vinogradova Ekaterina Lable-free detection of sialic acid using surface-enhanced raman scattering microscopy
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
US20170127983A1 (en) * 2015-11-10 2017-05-11 Massachusetts Institute Of Technology Systems and methods for sampling calibration of non-invasive analyte measurements
DK3291038T3 (da) 2016-08-31 2021-10-18 Sartorius Stedim Biotech Gmbh Kontrol og overvågning af en proces til fremstilling af et kemisk, farmaceutisk eller bioteknologisk produkt
AU2018350890B2 (en) * 2017-10-16 2024-07-04 Regeneron Pharmaceuticals, Inc. In situ Raman spectroscopy systems and methods for controlling process variables in cell cultures
US10810408B2 (en) * 2018-01-26 2020-10-20 Viavi Solutions Inc. Reduced false positive identification for spectroscopic classification

Also Published As

Publication number Publication date
HUE072452T2 (hu) 2025-11-28
IL281977B1 (en) 2024-11-01
US20220128474A1 (en) 2022-04-28
WO2020086635A1 (en) 2020-04-30
CN112912716A (zh) 2021-06-04
SG11202103232WA (en) 2021-05-28
KR20210078531A (ko) 2021-06-28
EP3870957B1 (en) 2025-07-16
IL281977B2 (en) 2025-03-01
LT3870957T (lt) 2025-10-10
ES3041713T3 (en) 2025-11-13
IL281977A (en) 2021-05-31
JP2022512775A (ja) 2022-02-07
PL3870957T3 (pl) 2025-11-17
AU2025205401A1 (en) 2025-07-31
TWI844570B (zh) 2024-06-11
BR112021007611A2 (pt) 2021-07-27
TW202033949A (zh) 2020-09-16
CL2021001024A1 (es) 2021-09-24
PT3870957T (pt) 2025-09-01
CN112912716B (zh) 2025-04-11
SI3870957T1 (sl) 2025-10-30
DK3870957T3 (da) 2025-09-29
JP7601760B2 (ja) 2024-12-17
MX2021004510A (es) 2021-06-08
FI3870957T3 (fi) 2025-09-30
CA3115296A1 (en) 2020-04-30
EP3870957A1 (en) 2021-09-01

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