AU2019306532A1 - Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis - Google Patents
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis Download PDFInfo
- Publication number
- AU2019306532A1 AU2019306532A1 AU2019306532A AU2019306532A AU2019306532A1 AU 2019306532 A1 AU2019306532 A1 AU 2019306532A1 AU 2019306532 A AU2019306532 A AU 2019306532A AU 2019306532 A AU2019306532 A AU 2019306532A AU 2019306532 A1 AU2019306532 A1 AU 2019306532A1
- Authority
- AU
- Australia
- Prior art keywords
- oxazepane
- carboxamide
- ethyl
- cyano
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000005777 Lupus Nephritis Diseases 0.000 title claims abstract description 34
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Landscapes
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- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
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| WO2020018547A1 (en) | 2018-07-17 | 2020-01-23 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis |
| US20240150335A1 (en) * | 2021-02-05 | 2024-05-09 | Medshine Discovery Inc. | Fused ring derivatives containing 1,4-oxazepane |
| EP4538271A4 (en) * | 2022-06-07 | 2025-10-08 | Reistone Biopharma Company Ltd | POLYMORPH OF BENZO[C]CHROMANE COMPOUND, ITS PREPARATION METHOD AND ITS USE |
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| PL1916994T3 (pl) | 2004-06-29 | 2014-05-30 | Takeda Pharma As | Wytwarzanie kompozycji farmaceutycznej o szybkim uwalnianiu leków nierozpuszczalnych w wodzie i kompozycje farmaceutyczne otrzymywane sposobem według wynalazku |
| CN103251953A (zh) | 2004-07-19 | 2013-08-21 | 约翰·霍普金斯大学 | 供免疫抑制的flt3抑制剂 |
| KR20070114753A (ko) | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| WO2007005668A2 (en) | 2005-06-30 | 2007-01-11 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
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-
2019
- 2019-07-16 WO PCT/US2019/042021 patent/WO2020018547A1/en not_active Ceased
- 2019-07-16 JP JP2021502574A patent/JP2021530525A/ja active Pending
- 2019-07-16 CA CA3106269A patent/CA3106269A1/en active Pending
- 2019-07-16 KR KR1020217004073A patent/KR20210032431A/ko not_active Ceased
- 2019-07-16 US US17/260,606 patent/US11998553B2/en active Active
- 2019-07-16 EP EP19837016.5A patent/EP3823627A4/en not_active Withdrawn
- 2019-07-16 AU AU2019306532A patent/AU2019306532A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3823627A1 (en) | 2021-05-26 |
| KR20210032431A (ko) | 2021-03-24 |
| US20210322438A1 (en) | 2021-10-21 |
| JP2021530525A (ja) | 2021-11-11 |
| WO2020018547A1 (en) | 2020-01-23 |
| US11998553B2 (en) | 2024-06-04 |
| CA3106269A1 (en) | 2020-01-23 |
| EP3823627A4 (en) | 2022-04-20 |
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