AU2019270091A1 - Compounds for treatment of pancreatic cancer - Google Patents
Compounds for treatment of pancreatic cancer Download PDFInfo
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- AU2019270091A1 AU2019270091A1 AU2019270091A AU2019270091A AU2019270091A1 AU 2019270091 A1 AU2019270091 A1 AU 2019270091A1 AU 2019270091 A AU2019270091 A AU 2019270091A AU 2019270091 A AU2019270091 A AU 2019270091A AU 2019270091 A1 AU2019270091 A1 AU 2019270091A1
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- Prior art keywords
- compound
- another embodiment
- alkyl
- formula
- haloalkyl
- Prior art date
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- 206010061902 Pancreatic neoplasm Diseases 0.000 title claims abstract description 140
- 201000002528 pancreatic cancer Diseases 0.000 title claims abstract description 140
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title claims abstract description 136
- 208000008443 pancreatic carcinoma Diseases 0.000 title claims abstract description 136
- 238000011282 treatment Methods 0.000 title description 36
- 238000000034 method Methods 0.000 claims abstract description 72
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- 125000004103 aminoalkyl group Chemical group 0.000 claims description 68
- 150000003839 salts Chemical class 0.000 claims description 63
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- 229910052731 fluorine Inorganic materials 0.000 claims description 60
- 239000001257 hydrogen Substances 0.000 claims description 57
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- 125000003282 alkyl amino group Chemical group 0.000 claims description 46
- 229920006395 saturated elastomer Polymers 0.000 claims description 31
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 26
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Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862671833P | 2018-05-15 | 2018-05-15 | |
| US62/671,833 | 2018-05-15 | ||
| PCT/US2019/032476 WO2019222392A1 (en) | 2018-05-15 | 2019-05-15 | Compounds for treatment of pancreatic cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019270091A1 true AU2019270091A1 (en) | 2020-12-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019270091A Abandoned AU2019270091A1 (en) | 2018-05-15 | 2019-05-15 | Compounds for treatment of pancreatic cancer |
Country Status (9)
| Country | Link |
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| US (1) | US20190374512A1 (https=) |
| EP (1) | EP3793548A4 (https=) |
| JP (1) | JP2021523915A (https=) |
| KR (1) | KR20210021982A (https=) |
| CN (1) | CN112437664A (https=) |
| AU (1) | AU2019270091A1 (https=) |
| CA (1) | CA3099922A1 (https=) |
| MX (1) | MX2020012292A (https=) |
| WO (1) | WO2019222392A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20230413A1 (es) * | 2020-04-03 | 2023-03-07 | Veru Inc | Metodos de tratamiento del coronavirus |
| CA3215936A1 (en) * | 2021-04-05 | 2022-10-13 | Veru Inc. | Methods of treating inflammation |
| CN119212696A (zh) * | 2022-04-28 | 2024-12-27 | 维鲁公司 | [2-(1h-吲哚-3-基)-1h-咪唑-4-基](3,4,5-三甲氧基)甲酮和其盐的多晶型物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029408B2 (en) * | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US8822513B2 (en) * | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) * | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| MX2010014066A (es) * | 2008-06-16 | 2011-06-01 | Univ Tennessee Res Foundation | Compuestos para el tratamiento del cancer. |
| JP5879273B2 (ja) * | 2010-03-01 | 2016-03-08 | ジーティーエックス・インコーポレイテッド | 癌を処置するための化合物 |
| JP5997156B2 (ja) * | 2010-08-24 | 2016-09-28 | ジーティーエックス・インコーポレイテッド | 癌の治療のための化合物 |
| CN105163584B (zh) * | 2013-03-05 | 2019-06-04 | 田纳西大学研究基金会 | 用于治疗癌症的化合物 |
-
2019
- 2019-05-15 KR KR1020207035812A patent/KR20210021982A/ko not_active Withdrawn
- 2019-05-15 MX MX2020012292A patent/MX2020012292A/es unknown
- 2019-05-15 US US16/413,222 patent/US20190374512A1/en not_active Abandoned
- 2019-05-15 AU AU2019270091A patent/AU2019270091A1/en not_active Abandoned
- 2019-05-15 CN CN201980046672.7A patent/CN112437664A/zh active Pending
- 2019-05-15 CA CA3099922A patent/CA3099922A1/en active Pending
- 2019-05-15 JP JP2020564201A patent/JP2021523915A/ja active Pending
- 2019-05-15 EP EP19802725.2A patent/EP3793548A4/en not_active Withdrawn
- 2019-05-15 WO PCT/US2019/032476 patent/WO2019222392A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3793548A4 (en) | 2022-03-09 |
| WO2019222392A1 (en) | 2019-11-21 |
| EP3793548A1 (en) | 2021-03-24 |
| KR20210021982A (ko) | 2021-03-02 |
| CN112437664A (zh) | 2021-03-02 |
| JP2021523915A (ja) | 2021-09-09 |
| CA3099922A1 (en) | 2019-11-21 |
| US20190374512A1 (en) | 2019-12-12 |
| MX2020012292A (es) | 2021-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |