AU2019101120A4 - Anti microbial/probiotics/functional/medicinal soft chew and lozenges plant-based gum - Google Patents

Anti microbial/probiotics/functional/medicinal soft chew and lozenges plant-based gum Download PDF

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Publication number
AU2019101120A4
AU2019101120A4 AU2019101120A AU2019101120A AU2019101120A4 AU 2019101120 A4 AU2019101120 A4 AU 2019101120A4 AU 2019101120 A AU2019101120 A AU 2019101120A AU 2019101120 A AU2019101120 A AU 2019101120A AU 2019101120 A4 AU2019101120 A4 AU 2019101120A4
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Prior art keywords
lozenges
soft chew
essential oil
natural
gum
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AU2019101120A
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Mohammad Sharif Sharifi
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Australian Food And Pharmaceutical Industries
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Australian Food And Pharmaceutical Ind
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Priority claimed from AU2019902106A external-priority patent/AU2019902106A0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oncology (AREA)

Abstract

Disclosed herein is the antimicrobial effect of the gum isolated from various specieis of the genus Pistacia. The gum may be incorporated into oral dosage forms, such as lozenges, soft-chews, and chewing gums, and used to deliver other actives such as vitamins and/or probiotics. Alternatively, the gum may be incorporated into hygiene products, such as mouth washes or shampoos.

Description

ANTI MICROBIAL/PROBIOTICS/FUNCTIONAL /MEDICINAL SOFT CHEW AND LOZENGES PLANT BASED GUM
The invention is described in the following statement
2019101120 26 Sep 2019
MICROBIAL/PROBIOTICS/FUNCTIONAL/MEDICINAL SOFT CHEW AND LOZENGES PLANT BASED GUM
Mastic gum from various species of the genus Pistacia contains an unusually high molecular weight polymer which, based on our research and studies, possesses antimicrobial activities. The molecular weight of this polymer has a significant impact on both the antimicrobial activities and the elasticity texture of the gum. Measures must therefore be taken to maintain the molecular weight within a range that optimises both properties for use. For the production of the soft chew and lozenges the gum is harvested at the latest stage, allowing the naturally occurring free radical polymerisation within the resin, which increases the molecular weight of the polymer fraction which heightens antimicrobial activity but compromises elasticity which is not needed for this purpose.
As the molecular weight of the polymer has significant impact on the antimicrobial activities, it is therefore necessary that the mastic gum used for probiotic chewing gum has a low molecular weight so as not to kill the probiotics but allowing to lose elasticity. Like the mastic we use for encapsulation.
The essential oil of the composite resin is extracted for use by an innovative and unique cold method, which prevents any negative impact on the polymerisation of the resin. The essential oil is also stored at low temperature as free radicals in the essential oil may initiate free radical polymerisation of Myrcene.
The remining resin has three major fractions: the weak acidic fractions, the strong acidic fractions and the neutral fractions. Each possesses different biological activities and impact on the gum's elasticity and taste in different ways. In order to have a suitable and a pleasant texture, it is important to reach a suitable ratio of these fractions.
2019101120 26 Sep 2019
The gum base by itself cannot serve as a soft chew or lozenges, therefore, other ingredients are added. These additional ingredients might or might not be essential and are comparable to those used in conventional soft chew and lozenges. The final base might or might not be blended in a sigma mixer with sugar and glucose or Xylitol, Maltitol, flavouring and artificial sweeteners for sugarless products. The remaining processes which roll, form, and coat the products are carried out via conventional methods.
Our product is distinctively unique as it is made from plant-based gums from a variety of trees, including — but not limited to — genus Pistacia. It is an environmentally friendly product that is biodegradable and offers health benefits of traditional medicine which have the support of evidence-based research and scientific papers.
These products can be produced with sugar or a sweetener. The preference is to use the sweetener, xylitol/isomalt which is diabetic-friendly — the latter also possessing purported dental hygiene benefits. These products can also be non-flavoured or flavoured with a broad variety of flavours such as natural essential oils. Vitamins D, E, A, K or a multi vitamin, hemp products, cannabinoids, calcium, analgesics, sildenafil and other functional compounds can be incorporated into the base or its coating to produce medicinal/ supplement natural soft chew and lozenges. It can also be incorporated with Nitroglycerin to relieve angina as Nitroglycerin is released slowly while the products are taken. After the gum base is made, the functional compounds are mixed into the gum itself, the coating or both.
Modified/non-antimicrobial plant base gum can also be incorporated with probiotics:
• Lactococcus lactis ssp. lactis;
• Lactococcus lactis ssp. cremoris;
2019101120 26 Sep 2019 • Lactococcus lactis spp. lactis biovar diacetylactis;
• Lactobacilluys brevis;
• Leuconostoc spp.;
• the yeast Saccharomyces cerevisiae • Blis M18 and K12
In summary soft chew and lozenges can deliver vast majority of the orally taken medication, probiotics and supplements.

Claims (14)

  1. CLAIMS MADE
    1. The soft chew and lozenges are made from natural resin.
  2. 2. The said soft chew and lozenges are therapeutic and possesses antimicrobial, antiviral, antitumor and cholesterol levelling properties.
  3. 3. The said soft chew and lozenges have gut health benefits, namely antihelicobacter, beneficial to Inflammatory Bowel Diseases (IBS), including but not limited to Crohn's disease, reflux heartburn and periodontal disease — gingivitis.
  4. 4. The said soft chew and lozenges are distinctively unique as it is made from plant-based gums from a variety of trees, including — but not limited to — genus Pistacia.
  5. 5. The said soft chew and lozenges are environmentally friendly product that is biodegradable and offers health benefits of traditional medicine which have the support of evidence-based research, clinical trials and scientific papers.
  6. 6. The said soft chew and lozenges are incorporated with functional/medicinal groups.
  7. 7. The modified gum base is incorporated with prebiotic/probiotics.
  8. 8. The natural resin by itself cannot serve as soft chew and lozenges, therefore, other ingredients are added. These additional ingredients might or might not be essential and are comparable to those used in conventional chewing gum.
  9. 9. The natural resin might or might not be blended in a sigma mixer with Xylitol, Maltitol, flavouring and artificial sweeteners.
    2019101120 26 Sep 2019
  10. 10. This natural resin can be blended with sugar or a sweetener. The preference is to use the sweetener, xylitol/isomalt which is diabetic-friendly — the latter also possessing purported dental hygiene benefits.
  11. 11. The essential oil of the natural resin is extracted for use by an innovative and unique cold method (vacuum followed by chilling process), which prevents any negative impact on the polymerisation of the resin. The essential oil is also stored at low temperature as remnant of free radicals in the essential oil may initiate free radical polymerisation of Myrcene.
  12. 12. The said essential oil is used as an antiseptic and healing remedy in the wound healing bandage.
  13. 13. The said essential oil is also used in natural mouth wash, natural lice shampoo, and natural insecticide.
  14. 14. The said essential oil is used in a remedy to dissolve kidney/bladder stones.
AU2019101120A 2019-06-18 2019-09-26 Anti microbial/probiotics/functional/medicinal soft chew and lozenges plant-based gum Active AU2019101120A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2019902106A AU2019902106A0 (en) 2019-06-18 ANTI MICROBIAL PLANT BASED CHEWING GUM. Our product is made from plant based gums from a variety of trees which exhibit antimicrobial activity. It is an environmentally friendly product that is biodegradable and offers health benefits. The said gum base is obtained from trunk exudates (gums) from various trees including the Dipterocarpaceae family of trees, mainly those of the genera Shorea, Balanocarpus or Hopea, and trees of the genus Pistachia. The trunk exudates of the aforementioned trees are mainly composed of triterpenes and triterpenoids with well-known antimicrobial activities.
AU2019902106 2019-06-18

Publications (1)

Publication Number Publication Date
AU2019101120A4 true AU2019101120A4 (en) 2019-10-31

Family

ID=68341981

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AU2019101120A Active AU2019101120A4 (en) 2019-06-18 2019-09-26 Anti microbial/probiotics/functional/medicinal soft chew and lozenges plant-based gum

Country Status (1)

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AU (1) AU2019101120A4 (en)

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