AU2018383712B2 - Cpf1-related methods and compositions for gene editing - Google Patents

Cpf1-related methods and compositions for gene editing

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Publication number
AU2018383712B2
AU2018383712B2 AU2018383712A AU2018383712A AU2018383712B2 AU 2018383712 B2 AU2018383712 B2 AU 2018383712B2 AU 2018383712 A AU2018383712 A AU 2018383712A AU 2018383712 A AU2018383712 A AU 2018383712A AU 2018383712 B2 AU2018383712 B2 AU 2018383712B2
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Australia
Prior art keywords
ascpf1
bcl11a
trac
ciita
sequence
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AU2018383712A
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AU2018383712A1 (en
Inventor
Jennifer GORI
Hariharan JAYARAM
John Zuris
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Editas Medicine Inc
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Editas Medicine Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • C12N5/0634—Cells from the blood or the immune system
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    • C12N9/14—Hydrolases (3)
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K2121/00—Preparations for use in therapy
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2018383712A 2017-12-11 2018-12-11 Cpf1-related methods and compositions for gene editing Active AU2018383712B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762597118P 2017-12-11 2017-12-11
US62/597,118 2017-12-11
US201862623501P 2018-01-29 2018-01-29
US62/623,501 2018-01-29
US201862664905P 2018-04-30 2018-04-30
US62/664,905 2018-04-30
US201862746494P 2018-10-16 2018-10-16
US62/746,494 2018-10-16
PCT/US2018/065032 WO2019118516A1 (en) 2017-12-11 2018-12-11 Cpf1-related methods and compositions for gene editing

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AU2025275210 Division 2018-12-11

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AU2018383712A1 AU2018383712A1 (en) 2020-07-02
AU2018383712B2 true AU2018383712B2 (en) 2025-09-04

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US (1) US20200299661A1 (enExample)
EP (1) EP3724326A1 (enExample)
JP (2) JP2021505187A (enExample)
KR (1) KR20200097760A (enExample)
CN (1) CN111712569A (enExample)
AU (1) AU2018383712B2 (enExample)
CA (1) CA3085338A1 (enExample)
MX (1) MX2020006072A (enExample)
WO (1) WO2019118516A1 (enExample)

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