AU2018351649B2 - Methods for treating hepatitis B infection - Google Patents

Methods for treating hepatitis B infection Download PDF

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Publication number
AU2018351649B2
AU2018351649B2 AU2018351649A AU2018351649A AU2018351649B2 AU 2018351649 B2 AU2018351649 B2 AU 2018351649B2 AU 2018351649 A AU2018351649 A AU 2018351649A AU 2018351649 A AU2018351649 A AU 2018351649A AU 2018351649 B2 AU2018351649 B2 AU 2018351649B2
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Australia
Prior art keywords
oligonucleotide
nucleotides
hbv
positions
antisense strand
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AU2018351649A
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AU2018351649A1 (en
Inventor
Marc Abrams
Martin KOSER
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Dicerna Pharmaceuticals Inc
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Dicerna Pharmaceuticals Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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AU2018351649A 2017-10-20 2018-10-19 Methods for treating hepatitis B infection Active AU2018351649B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762575358P 2017-10-20 2017-10-20
US62/575,358 2017-10-20
PCT/US2018/056801 WO2019079781A2 (en) 2017-10-20 2018-10-19 METHODS OF TREATING HEPATITIS B TYPE INFECTIONS

Publications (2)

Publication Number Publication Date
AU2018351649A1 AU2018351649A1 (en) 2020-04-23
AU2018351649B2 true AU2018351649B2 (en) 2025-04-24

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AU2018351649A Active AU2018351649B2 (en) 2017-10-20 2018-10-19 Methods for treating hepatitis B infection

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US (5) US10799524B2 (enExample)
EP (2) EP3684377B1 (enExample)
JP (2) JP7353276B2 (enExample)
KR (1) KR102783206B1 (enExample)
CN (2) CN118185936A (enExample)
AU (1) AU2018351649B2 (enExample)
BR (1) BR112020007476A2 (enExample)
CA (1) CA3078960A1 (enExample)
CL (1) CL2020001061A1 (enExample)
CO (1) CO2020005135A2 (enExample)
CR (1) CR20200163A (enExample)
DK (1) DK3684377T3 (enExample)
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IL282881B2 (en) 2017-10-20 2024-10-01 Dicerna Pharmaceuticals Inc Methods for treating hepatitis b infection
AU2019300324A1 (en) 2018-07-13 2021-01-21 F. Hoffmann-La Roche Ag Oligonucleotides for modulating RTEL1 expression
AU2020358016A1 (en) * 2019-10-02 2022-04-21 Dicerna Pharmaceuticals, Inc. Chemical modifications of small interfering RNA with minimal fluorine content
EP4077671A1 (en) * 2019-12-19 2022-10-26 F. Hoffmann-La Roche AG Use of saraf inhibitors for treating hepatitis b virus infection
WO2021130266A1 (en) * 2019-12-24 2021-07-01 F. Hoffmann-La Roche Ag Pharmaceutical combination of a therapeutic oligonucleotide targeting hbv and a tlr7 agonist for treatment of hbv
EP4081217A1 (en) * 2019-12-24 2022-11-02 F. Hoffmann-La Roche AG Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
US20220056451A1 (en) * 2020-07-27 2022-02-24 Aligos Therapeutics, Inc. Hbv binding oligonucleotides and methods of use
CA3190794A1 (en) * 2020-08-05 2022-02-10 Soren Ottosen Oligonucleotide treatment of hepatitis b patients
WO2022131883A1 (ko) * 2020-12-18 2022-06-23 올릭스 주식회사 HBV 발현을 억제하는 RNAi 제제 및 이의 용도
CN114853829A (zh) * 2021-02-05 2022-08-05 上海拓界生物医药科技有限公司 一种核酸配体、其缀合物、制备方法及用途
CN114940991B (zh) * 2021-04-13 2023-02-03 厦门甘宝利生物医药有限公司 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用
CA3213775A1 (en) 2021-04-19 2022-10-27 Utsav SAXENA Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression
AU2022384619A1 (en) 2021-11-11 2024-04-11 F. Hoffmann-La Roche Ag Pharmaceutical combinations for treatment of hbv
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