AU2018269304B2 - Preparation of biologically active complexes - Google Patents

Preparation of biologically active complexes Download PDF

Info

Publication number
AU2018269304B2
AU2018269304B2 AU2018269304A AU2018269304A AU2018269304B2 AU 2018269304 B2 AU2018269304 B2 AU 2018269304B2 AU 2018269304 A AU2018269304 A AU 2018269304A AU 2018269304 A AU2018269304 A AU 2018269304A AU 2018269304 B2 AU2018269304 B2 AU 2018269304B2
Authority
AU
Australia
Prior art keywords
oleate
peptide
alpha
lactalbumin
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018269304A
Other languages
English (en)
Other versions
AU2018269304A1 (en
Inventor
Chin Shing HO
Aftab NADEEM
Catharina Svanborg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamlet Pharma AB
Original Assignee
Hamlet Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamlet Pharma AB filed Critical Hamlet Pharma AB
Publication of AU2018269304A1 publication Critical patent/AU2018269304A1/en
Application granted granted Critical
Publication of AU2018269304B2 publication Critical patent/AU2018269304B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Inorganic Chemistry (AREA)
AU2018269304A 2017-05-14 2018-05-14 Preparation of biologically active complexes Active AU2018269304B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1707715.7 2017-05-14
GBGB1707715.7A GB201707715D0 (en) 2017-05-14 2017-05-14 Preperation of biologically active complexes
PCT/EP2018/062396 WO2018210759A1 (en) 2017-05-14 2018-05-14 Preparation of biologically active complexes

Publications (2)

Publication Number Publication Date
AU2018269304A1 AU2018269304A1 (en) 2019-11-21
AU2018269304B2 true AU2018269304B2 (en) 2025-02-27

Family

ID=59201543

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018269304A Active AU2018269304B2 (en) 2017-05-14 2018-05-14 Preparation of biologically active complexes

Country Status (13)

Country Link
US (3) US20200140481A1 (https=)
EP (2) EP3811967B1 (https=)
JP (2) JP7672122B2 (https=)
KR (2) KR20200015557A (https=)
CN (2) CN119700935A (https=)
AU (1) AU2018269304B2 (https=)
CA (1) CA3063285A1 (https=)
DK (2) DK3618848T3 (https=)
ES (2) ES2861252T3 (https=)
FI (1) FI3811967T3 (https=)
GB (1) GB201707715D0 (https=)
PL (2) PL3618848T3 (https=)
WO (1) WO2018210759A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201621752D0 (en) * 2016-12-20 2017-02-01 Hamlet Pharma Ab Therapeutically active complexes
GB201707715D0 (en) * 2017-05-14 2017-06-28 Hamlet Pharma Ab Preperation of biologically active complexes
GB2574845A (en) * 2018-06-20 2019-12-25 Hamlet Pharma Ab Therapeutically active complexes
WO2019243547A1 (en) * 2018-06-20 2019-12-26 Hamlet Pharma Ab Therapeutically active complexes
WO2021032807A1 (en) * 2019-08-20 2021-02-25 Hamlet Pharma Ab Combination of a chemotherapeutic agent and alpha-lactoglubulin-oleic acid complex for cancer therapy
GB202015836D0 (en) * 2020-10-06 2020-11-18 Hamlet Pharma Ab Compositions
US20260108588A1 (en) 2022-10-03 2026-04-23 Linnane Pharma Ab A complex comprising a alpha-lactalbumin and a fatty acid or lipid for use in the treatment or prevention of cancer
GB202303177D0 (en) 2023-03-03 2023-04-19 Linnane Pharma Ab Method of predicting response to treatment
WO2025186107A1 (en) 2024-03-04 2025-09-12 Linnane Pharma Ab Therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069836A2 (en) * 2010-11-24 2012-05-31 Hamlet Pharma Ab Biologically active complex and its preparation
WO2014023976A1 (en) * 2012-08-09 2014-02-13 Hamlet Pharma Ab Prophylactic and nutraceutical therapy
WO2018116165A2 (en) * 2016-12-20 2018-06-28 Hamlet Pharma Ab Therapeutically active complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1871252A (zh) * 2003-09-05 2006-11-29 Gtc生物治疗学公司 在转基因哺乳动物奶中生产融合蛋白的方法
US8796218B2 (en) 2009-01-09 2014-08-05 Hamlet Pharma Ab Complex and production process
WO2010131237A1 (en) 2009-05-13 2010-11-18 Agriculture And Food Development Authority (Teagasc) A process for producing a biologically active globular protein complex
GB0908279D0 (en) 2009-05-14 2009-06-24 Enovate Systems Ltd Subsea winch
GB201707715D0 (en) * 2017-05-14 2017-06-28 Hamlet Pharma Ab Preperation of biologically active complexes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069836A2 (en) * 2010-11-24 2012-05-31 Hamlet Pharma Ab Biologically active complex and its preparation
WO2014023976A1 (en) * 2012-08-09 2014-02-13 Hamlet Pharma Ab Prophylactic and nutraceutical therapy
WO2018116165A2 (en) * 2016-12-20 2018-06-28 Hamlet Pharma Ab Therapeutically active complexes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Svensson, M., Håkansson, A., Mossberg, A.K., Linse, S. and Svanborg, C., 2000. Conversion of α-lactalbumin to a protein inducing apoptosis. Proceedings of the National Academy of Sciences, 97(8), pp.4221-4226. *
VUKOJEVIC ET AL: "Lipoprotein complex of equine lysozyme with oleic acid (ELOA) interactions with the plasma membrane of live cells", vol. 26, no. 18, 2010-01-01, pp 14782 - 14787, Internet URL: http://pubs.acs.org/doi/abs/10.1021/la1026416 *

Also Published As

Publication number Publication date
ES2973290T3 (es) 2024-06-19
AU2018269304A1 (en) 2019-11-21
DK3811967T5 (da) 2024-08-19
EP3811967A1 (en) 2021-04-28
US12331073B2 (en) 2025-06-17
CN119700935A (zh) 2025-03-28
KR20260021814A (ko) 2026-02-13
PL3811967T3 (pl) 2024-03-18
EP3618848B1 (en) 2020-11-25
DK3618848T3 (da) 2021-03-01
KR20200015557A (ko) 2020-02-12
GB201707715D0 (en) 2017-06-28
JP7672122B2 (ja) 2025-05-07
CA3063285A1 (en) 2018-11-22
EP3811967B1 (en) 2023-12-20
JP2023075290A (ja) 2023-05-30
US20260085088A1 (en) 2026-03-26
JP7705160B2 (ja) 2025-07-09
ES2861252T3 (es) 2021-10-06
JP2020519673A (ja) 2020-07-02
US20200140481A1 (en) 2020-05-07
CN110650746A (zh) 2020-01-03
CN110650746B (zh) 2024-12-31
WO2018210759A1 (en) 2018-11-22
US20210130394A1 (en) 2021-05-06
PL3618848T3 (pl) 2021-06-14
FI3811967T3 (fi) 2023-12-28
DK3811967T3 (da) 2024-01-08
EP3618848A1 (en) 2020-03-11

Similar Documents

Publication Publication Date Title
AU2018269304B2 (en) Preparation of biologically active complexes
JP2016540739A (ja) 神経保護ペプチド
KR102050621B1 (ko) Rtrail 변이체 및 이의 모노메틸 오리스타틴 e 접합체
US20230372450A1 (en) Method for preparing a composition comprising an unfolded protein
HK1251001A1 (zh) Il-37变体
TWI579299B (zh) 去整合蛋白變異體及其醫藥用途
JP2003516931A (ja) ペプチド作成の方法
CN102205114A (zh) 促红细胞生成素来源肽在制备治疗神经系统自身免疫性疾病的药物中的应用
US20220153781A1 (en) Tumor Targeting Polypeptide and Method of Use Thereof
HK40050699A (en) Preparation of biologically active complexes
HK40050699B (en) Preparation of biologically active complexes
CN115666522B (zh) 包含il-2蛋白和cd80蛋白的融合蛋白制剂
HK40025666B (en) Biologically active complexes and therapeutic uses thereof
HK40025666A (en) Biologically active complexes and therapeutic uses thereof
JP2003522116A (ja) 細胞内信号伝達を攪乱させる合成ペプチド
WO2011025050A1 (ja) アポトーシス誘導剤
GB2574845A (en) Therapeutically active complexes

Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ NADEEM, AFTAB; SVANBORG, CATHARINA AND HO, CHIN SHING

FGA Letters patent sealed or granted (standard patent)