AU2018269304B2 - Preparation of biologically active complexes - Google Patents

Preparation of biologically active complexes Download PDF

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Publication number
AU2018269304B2
AU2018269304B2 AU2018269304A AU2018269304A AU2018269304B2 AU 2018269304 B2 AU2018269304 B2 AU 2018269304B2 AU 2018269304 A AU2018269304 A AU 2018269304A AU 2018269304 A AU2018269304 A AU 2018269304A AU 2018269304 B2 AU2018269304 B2 AU 2018269304B2
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AU
Australia
Prior art keywords
oleate
peptide
alpha
lactalbumin
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2018269304A
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English (en)
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AU2018269304A1 (en
Inventor
Chin Shing HO
Aftab NADEEM
Catharina Svanborg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamlet Pharma AB
Original Assignee
Hamlet Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hamlet Pharma AB filed Critical Hamlet Pharma AB
Publication of AU2018269304A1 publication Critical patent/AU2018269304A1/en
Application granted granted Critical
Publication of AU2018269304B2 publication Critical patent/AU2018269304B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Water Supply & Treatment (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2018269304A 2017-05-14 2018-05-14 Preparation of biologically active complexes Active AU2018269304B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1707715.7A GB201707715D0 (en) 2017-05-14 2017-05-14 Preperation of biologically active complexes
GB1707715.7 2017-05-14
PCT/EP2018/062396 WO2018210759A1 (en) 2017-05-14 2018-05-14 Preparation of biologically active complexes

Publications (2)

Publication Number Publication Date
AU2018269304A1 AU2018269304A1 (en) 2019-11-21
AU2018269304B2 true AU2018269304B2 (en) 2025-02-27

Family

ID=59201543

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018269304A Active AU2018269304B2 (en) 2017-05-14 2018-05-14 Preparation of biologically active complexes

Country Status (13)

Country Link
US (2) US20200140481A1 (enExample)
EP (2) EP3618848B1 (enExample)
JP (2) JP7672122B2 (enExample)
KR (1) KR20200015557A (enExample)
CN (2) CN119700935A (enExample)
AU (1) AU2018269304B2 (enExample)
CA (1) CA3063285A1 (enExample)
DK (2) DK3618848T3 (enExample)
ES (2) ES2973290T3 (enExample)
FI (1) FI3811967T3 (enExample)
GB (1) GB201707715D0 (enExample)
PL (2) PL3618848T3 (enExample)
WO (1) WO2018210759A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201621752D0 (en) * 2016-12-20 2017-02-01 Hamlet Pharma Ab Therapeutically active complexes
GB201707715D0 (en) 2017-05-14 2017-06-28 Hamlet Pharma Ab Preperation of biologically active complexes
GB2574845A (en) * 2018-06-20 2019-12-25 Hamlet Pharma Ab Therapeutically active complexes
WO2019243547A1 (en) * 2018-06-20 2019-12-26 Hamlet Pharma Ab Therapeutically active complexes
US20220323391A1 (en) * 2019-08-20 2022-10-13 Hamlet Pharma Ab Combination of a chemotherapeutic agent and alpha-lactoglubulin-oleic acid complex for cancer therapy
GB202015836D0 (en) * 2020-10-06 2020-11-18 Hamlet Pharma Ab Compositions
AU2023357946A1 (en) 2022-10-03 2025-04-24 Linnane Pharma Ab A complex comprising a alpha-lactalbumin and a fatty acid or lipid for use in the treatment or prevention of cancer
GB202303177D0 (en) 2023-03-03 2023-04-19 Linnane Pharma Ab Method of predicting response to treatment
WO2025186107A1 (en) 2024-03-04 2025-09-12 Linnane Pharma Ab Therapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069836A2 (en) * 2010-11-24 2012-05-31 Hamlet Pharma Ab Biologically active complex and its preparation
WO2014023976A1 (en) * 2012-08-09 2014-02-13 Hamlet Pharma Ab Prophylactic and nutraceutical therapy
WO2018116165A2 (en) * 2016-12-20 2018-06-28 Hamlet Pharma Ab Therapeutically active complexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503838A (ja) * 2003-09-05 2007-03-01 ジーティーシー バイオセラピューティクス， インコーポレイティド トランスジェニック動物の乳汁中での融合タンパク質の産生方法
JP5679992B2 (ja) * 2009-01-09 2015-03-04 ハムレット・ファルマ・アーベー 複合体および生産方法
WO2010131237A1 (en) 2009-05-13 2010-11-18 Agriculture And Food Development Authority (Teagasc) A process for producing a biologically active globular protein complex
GB0908279D0 (en) 2009-05-14 2009-06-24 Enovate Systems Ltd Subsea winch
GB201707715D0 (en) * 2017-05-14 2017-06-28 Hamlet Pharma Ab Preperation of biologically active complexes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012069836A2 (en) * 2010-11-24 2012-05-31 Hamlet Pharma Ab Biologically active complex and its preparation
WO2014023976A1 (en) * 2012-08-09 2014-02-13 Hamlet Pharma Ab Prophylactic and nutraceutical therapy
WO2018116165A2 (en) * 2016-12-20 2018-06-28 Hamlet Pharma Ab Therapeutically active complexes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Svensson, M., Håkansson, A., Mossberg, A.K., Linse, S. and Svanborg, C., 2000. Conversion of α-lactalbumin to a protein inducing apoptosis. Proceedings of the National Academy of Sciences, 97(8), pp.4221-4226. *
VUKOJEVIC ET AL: "Lipoprotein complex of equine lysozyme with oleic acid (ELOA) interactions with the plasma membrane of live cells", vol. 26, no. 18, 2010-01-01, pp 14782 - 14787, Internet URL: http://pubs.acs.org/doi/abs/10.1021/la1026416 *

Also Published As

Publication number Publication date
CN110650746A (zh) 2020-01-03
EP3618848B1 (en) 2020-11-25
KR20200015557A (ko) 2020-02-12
DK3618848T3 (da) 2021-03-01
ES2861252T3 (es) 2021-10-06
CN119700935A (zh) 2025-03-28
US20200140481A1 (en) 2020-05-07
AU2018269304A1 (en) 2019-11-21
EP3618848A1 (en) 2020-03-11
FI3811967T3 (fi) 2023-12-28
JP7672122B2 (ja) 2025-05-07
GB201707715D0 (en) 2017-06-28
JP7705160B2 (ja) 2025-07-09
US12331073B2 (en) 2025-06-17
CN110650746B (zh) 2024-12-31
JP2023075290A (ja) 2023-05-30
DK3811967T3 (da) 2024-01-08
PL3618848T3 (pl) 2021-06-14
JP2020519673A (ja) 2020-07-02
DK3811967T5 (da) 2024-08-19
EP3811967B1 (en) 2023-12-20
CA3063285A1 (en) 2018-11-22
PL3811967T3 (pl) 2024-03-18
US20210130394A1 (en) 2021-05-06
ES2973290T3 (es) 2024-06-19
EP3811967A1 (en) 2021-04-28
WO2018210759A1 (en) 2018-11-22

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ NADEEM, AFTAB; SVANBORG, CATHARINA AND HO, CHIN SHING

FGA Letters patent sealed or granted (standard patent)