AU2018260183B2 - Bi- or multi-differentiated organoid - Google Patents

Bi- or multi-differentiated organoid Download PDF

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AU2018260183B2
AU2018260183B2 AU2018260183A AU2018260183A AU2018260183B2 AU 2018260183 B2 AU2018260183 B2 AU 2018260183B2 AU 2018260183 A AU2018260183 A AU 2018260183A AU 2018260183 A AU2018260183 A AU 2018260183A AU 2018260183 B2 AU2018260183 B2 AU 2018260183B2
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tissue
ventral
neuronal tissue
gfp
differentiation
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AU2018260183A1 (en
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Joshua A. BAGLEY
Jürgen KNOBLICH
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IMBA Institut fur Molekulare Biotechonologie GmbH
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IMBA Institut fur Molekulare Biotechonologie GmbH
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2510/00—Genetically modified cells
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    • C12N2513/00—3D culture
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2018260183A 2017-04-25 2018-04-25 Bi- or multi-differentiated organoid Active AU2018260183B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17168051.5A EP3395942A1 (en) 2017-04-25 2017-04-25 Bi- or multi-differentiated organoid
EP17168051.5 2017-04-25
PCT/EP2018/060559 WO2018197544A1 (en) 2017-04-25 2018-04-25 Bi- or multi-differentiated organoid

Publications (2)

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AU2018260183A1 AU2018260183A1 (en) 2019-10-31
AU2018260183B2 true AU2018260183B2 (en) 2024-09-19

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US (1) US20210095260A1 (OSRAM)
EP (2) EP3395942A1 (OSRAM)
JP (1) JP7248590B2 (OSRAM)
KR (1) KR102692498B1 (OSRAM)
CN (2) CN119101651A (OSRAM)
AU (1) AU2018260183B2 (OSRAM)
CA (1) CA3061412A1 (OSRAM)
SG (1) SG11201909470TA (OSRAM)
WO (1) WO2018197544A1 (OSRAM)

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US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
WO2019023693A1 (en) * 2017-07-28 2019-01-31 Memorial Sloan-Kettering Cancer Center ESTABLISHING A TOPOGRAPHIC ORGANIZATION IN A THREE DIMENSIONAL FABRIC CULTURE
JP2020536529A (ja) 2017-10-10 2020-12-17 チルドレンズ ホスピタル メディカル センター 食道組織および／または臓器組成物およびそれを作製する方法
AU2018379993A1 (en) * 2017-12-04 2020-07-02 Axosim, Inc. Cell systems using spheroids and methods of making and using the same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CA3106634A1 (en) * 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
JP7610533B2 (ja) 2019-05-31 2025-01-08 チルドレンズ ホスピタル メディカル センター 造血幹細胞の生成および拡大方法
EP4176062A4 (en) * 2020-07-06 2024-10-16 President and Fellows of Harvard College PROGRAMMABLE ORGANOIDS AND THEIR PRODUCTION METHODS BY ORTHOGONAL DIFFERENTIATION AND BIOPRINTING
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DE102021132190A1 (de) * 2021-12-07 2023-06-22 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Biokompatible Strukturen zur Verbindung und Kultivierung von biologischem Material
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EP4286513A1 (en) 2022-06-03 2023-12-06 IMBA-Institut für Molekulare Biotechnologie GmbH Triple tissue culture fusion
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CN118530833B (zh) * 2024-04-02 2024-11-29 武汉大学 一种同步共分化的多组织或多类器官模型及其构建方法

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WO2018197544A1 (en) 2018-11-01
JP2020517283A (ja) 2020-06-18
EP3395942A1 (en) 2018-10-31
CN110573609A (zh) 2019-12-13
SG11201909470TA (en) 2019-11-28
KR20190141231A (ko) 2019-12-23
EP3615661A1 (en) 2020-03-04
JP7248590B2 (ja) 2023-03-29
AU2018260183A1 (en) 2019-10-31
US20210095260A1 (en) 2021-04-01
KR102692498B1 (ko) 2024-08-05
CN119101651A (zh) 2024-12-10
CA3061412A1 (en) 2018-11-01

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