AU2018246310B2 - Carrier composition for bone substitute materials - Google Patents
Carrier composition for bone substitute materials Download PDFInfo
- Publication number
- AU2018246310B2 AU2018246310B2 AU2018246310A AU2018246310A AU2018246310B2 AU 2018246310 B2 AU2018246310 B2 AU 2018246310B2 AU 2018246310 A AU2018246310 A AU 2018246310A AU 2018246310 A AU2018246310 A AU 2018246310A AU 2018246310 B2 AU2018246310 B2 AU 2018246310B2
- Authority
- AU
- Australia
- Prior art keywords
- carrier composition
- osteoconductive
- osteoinductive
- bone substitute
- silica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 91
- 239000000463 material Substances 0.000 title claims abstract description 62
- 239000000316 bone substitute Substances 0.000 title claims abstract description 56
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 111
- 239000000017 hydrogel Substances 0.000 claims abstract description 71
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 57
- 239000002245 particle Substances 0.000 claims abstract description 46
- 239000008187 granular material Substances 0.000 claims abstract description 45
- 230000002138 osteoinductive effect Effects 0.000 claims abstract description 45
- 230000000278 osteoconductive effect Effects 0.000 claims abstract description 44
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000002105 nanoparticle Substances 0.000 claims abstract description 36
- 229920001400 block copolymer Polymers 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 14
- 230000008569 process Effects 0.000 claims abstract description 7
- 229920001992 poloxamer 407 Polymers 0.000 claims description 29
- 238000009826 distribution Methods 0.000 claims description 21
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 17
- 210000000988 bone and bone Anatomy 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 11
- 229940044476 poloxamer 407 Drugs 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
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- 229910002027 silica gel Inorganic materials 0.000 claims description 6
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- 230000002776 aggregation Effects 0.000 claims description 4
- 238000004220 aggregation Methods 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 3
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- 238000002360 preparation method Methods 0.000 claims description 2
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- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 18
- 239000012876 carrier material Substances 0.000 description 18
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- 241001465754 Metazoa Species 0.000 description 3
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- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
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- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
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- LCSKNASZPVZHEG-UHFFFAOYSA-N 3,6-dimethyl-1,4-dioxane-2,5-dione;1,4-dioxane-2,5-dione Chemical group O=C1COC(=O)CO1.CC1OC(=O)C(C)OC1=O LCSKNASZPVZHEG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
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- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B28B—SHAPING CLAY OR OTHER CERAMIC COMPOSITIONS; SHAPING SLAG; SHAPING MIXTURES CONTAINING CEMENTITIOUS MATERIAL, e.g. PLASTER
- B28B3/00—Producing shaped articles from the material by using presses; Presses specially adapted therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- C08L71/02—Polyalkylene oxides
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
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- Transplantation (AREA)
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- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Dispersion Chemistry (AREA)
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- General Physics & Mathematics (AREA)
- Ceramic Engineering (AREA)
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- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
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EP17163687.1A EP3381479A1 (de) | 2017-03-29 | 2017-03-29 | Trägerzusammensetzung für knochenersatzmaterialien |
EP17163687.1 | 2017-03-29 | ||
PCT/EP2018/058132 WO2018178266A1 (de) | 2017-03-29 | 2018-03-29 | Trägerzusammensetzung für knochenersatzmaterialien |
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AU2018246310A1 AU2018246310A1 (en) | 2019-10-24 |
AU2018246310B2 true AU2018246310B2 (en) | 2023-07-20 |
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AU2018246310A Active AU2018246310B2 (en) | 2017-03-29 | 2018-03-29 | Carrier composition for bone substitute materials |
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EP (2) | EP3381479A1 (es) |
JP (1) | JP7118132B2 (es) |
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CN (1) | CN110650754B (es) |
AU (1) | AU2018246310B2 (es) |
CA (1) | CA3058253A1 (es) |
ES (1) | ES2917406T3 (es) |
MX (1) | MX2019011659A (es) |
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EP3381479A1 (de) * | 2017-03-29 | 2018-10-03 | ARTOSS GmbH | Trägerzusammensetzung für knochenersatzmaterialien |
US11560509B2 (en) | 2020-11-18 | 2023-01-24 | Saudi Arabian Oil Company | Reversible mechanically triggered nanosilica gels |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140105884A1 (en) * | 2010-01-20 | 2014-04-17 | Theracoat Ltd. | Material and method for treating internal cavities |
WO2016037249A1 (pt) * | 2014-09-11 | 2016-03-17 | Universidade Estadual De Campinas - Unicamp | Processo de obtencão de um sistema híbrido, sistema híbrido e seu uso |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314991A (en) * | 1980-07-25 | 1982-02-09 | Johnson & Johnson Products Inc. | Sulfonated polyamino acids as dental plaque barriers |
CA1167382A (en) * | 1980-07-25 | 1984-05-15 | Tibor Sipos | Zinc salts of sulfonated poly (arylene ether sulfone) polymers as highly substantive dental plaque barriers |
US6787342B2 (en) * | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
EP1344538A1 (en) * | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
EP1433489A1 (en) * | 2002-12-23 | 2004-06-30 | Degradable Solutions AG | Biodegradable porous bone implant with a barrier membrane sealed thereto |
US20060140904A1 (en) | 2003-02-12 | 2006-06-29 | Tadeusz Wellisz | Random alkylene oxide copolymers for medical and surgical utilities |
RU2354408C2 (ru) * | 2003-05-22 | 2009-05-10 | Артосс Гмбх | Неорганический резорбируемый материал для замены костей |
KR20060085682A (ko) * | 2003-10-10 | 2006-07-27 | 라이프사이클 파마 에이/에스 | 피브레이트 및 스타틴을 함유하는 고형 제제 |
DE102005040848A1 (de) * | 2005-08-29 | 2007-03-01 | Artoss Gmbh | Osteoinduktives Material und Verfahren zur Herstellung desselben |
ATE482690T1 (de) * | 2005-12-14 | 2010-10-15 | Hoffmann La Roche | Hcv-prodrug-formulierung |
WO2008017203A1 (en) * | 2006-08-01 | 2008-02-14 | Unilever Plc | Biomaterials, their preparation and use |
WO2011137231A1 (en) * | 2010-04-29 | 2011-11-03 | Warsaw Orthopedic, Inc. | Flowable ceramic putty |
FR2962046B1 (fr) * | 2010-07-02 | 2012-08-17 | Commissariat Energie Atomique | Gel de decontamination biologique et procede de decontamination de surfaces utilisant ce gel. |
KR20140009449A (ko) | 2011-03-03 | 2014-01-22 | 스파인아트 에스. 에이. | 제품 |
TW201247225A (en) * | 2011-05-17 | 2012-12-01 | Univ Nat Chiao Tung | Drug carrier with thermal sensitivity, manufacturing method thereof, and use of the same as NMR contrast agent |
CN102380334A (zh) * | 2011-07-25 | 2012-03-21 | 重庆文理学院 | 一种具三维孔道结构的介孔高分子或碳/氧化硅纳米复合材料及其制备方法 |
US20140005306A1 (en) * | 2012-06-21 | 2014-01-02 | Polytechnic Institute Of New York University | Hyaluronic Acid-Gelatin Crosslinked Thermoreversible Pluronic Hydrogels |
DE102012223416A1 (de) | 2012-12-17 | 2014-07-03 | Polymaterials Ag | Kettenverlängerte Poloxamere, daraus gebildete thermoreversible Hydrogele mit biologischen Materialien, und medizinische Anwendungen derselben |
EP2934394A4 (en) | 2012-12-18 | 2016-07-27 | Novabone Products Llc | BIOACTIVE GLASS WITH PROPYLENE OXIDE AND ETHYLENE OXIDE BLOCK COPOLYMERS |
JP2016514030A (ja) * | 2013-03-14 | 2016-05-19 | ジェンザイム・コーポレーション | 感熱性骨成長組成物 |
KR101443814B1 (ko) | 2013-03-28 | 2014-09-30 | 주식회사 바이오알파 | 골 이식재 조성물 및 이의 제조방법 |
EP2813213A1 (en) * | 2013-06-12 | 2014-12-17 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Injectable hydrogel composition, method for the preparation and uses thereof |
CN103830184A (zh) * | 2014-02-18 | 2014-06-04 | 北京大学 | 非布索坦的固体分散系统及其制备方法和制药应用 |
EP3152250A4 (en) * | 2014-06-04 | 2018-01-03 | Klox Technologies Inc. | Biophotonic hydrogels |
US9883279B2 (en) * | 2014-07-31 | 2018-01-30 | Khyber Technologies Corporation | Wireless headset system |
CN104147633B (zh) * | 2014-08-08 | 2016-08-31 | 华东理工大学 | 一种具有抗菌性能的介孔止血颗粒及其制备方法和应用 |
US9567514B2 (en) * | 2015-05-13 | 2017-02-14 | Pacific Light Technologies Corp. | Composition of, and method for forming, a semiconductor structure with multiple insulator coatings |
US20180179357A1 (en) * | 2016-12-27 | 2018-06-28 | Board Of Trustees Of Michigan State University | Energy dissipative composition including a hydrogel reinforced with nanoporous particles |
EP3381479A1 (de) * | 2017-03-29 | 2018-10-03 | ARTOSS GmbH | Trägerzusammensetzung für knochenersatzmaterialien |
-
2017
- 2017-03-29 EP EP17163687.1A patent/EP3381479A1/de not_active Withdrawn
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2018
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- 2018-03-29 EP EP18712926.7A patent/EP3600464B1/de active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140105884A1 (en) * | 2010-01-20 | 2014-04-17 | Theracoat Ltd. | Material and method for treating internal cavities |
WO2016037249A1 (pt) * | 2014-09-11 | 2016-03-17 | Universidade Estadual De Campinas - Unicamp | Processo de obtencão de um sistema híbrido, sistema híbrido e seu uso |
Non-Patent Citations (1)
Title |
---|
MUNOZ A. et al., 'Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats', Life Sci. (2017), Vol 171, pages 60 - 67. * |
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MX2019011659A (es) | 2022-04-04 |
RU2019132821A3 (es) | 2021-06-21 |
JP7118132B2 (ja) | 2022-08-15 |
US11324859B2 (en) | 2022-05-10 |
JP2020512175A (ja) | 2020-04-23 |
BR112019020029A2 (pt) | 2020-04-28 |
KR20200021447A (ko) | 2020-02-28 |
EP3600464B1 (de) | 2022-05-04 |
ES2917406T3 (es) | 2022-07-08 |
RU2019132821A (ru) | 2021-04-29 |
RU2768695C2 (ru) | 2022-03-24 |
US20210093752A1 (en) | 2021-04-01 |
WO2018178266A1 (de) | 2018-10-04 |
EP3600464A1 (de) | 2020-02-05 |
CN110650754B (zh) | 2022-07-22 |
CA3058253A1 (en) | 2018-10-04 |
AU2018246310A1 (en) | 2019-10-24 |
KR102523981B1 (ko) | 2023-04-20 |
EP3381479A1 (de) | 2018-10-03 |
CN110650754A (zh) | 2020-01-03 |
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