AU2018244442A1 - Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same - Google Patents

Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same Download PDF

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Publication number
AU2018244442A1
AU2018244442A1 AU2018244442A AU2018244442A AU2018244442A1 AU 2018244442 A1 AU2018244442 A1 AU 2018244442A1 AU 2018244442 A AU2018244442 A AU 2018244442A AU 2018244442 A AU2018244442 A AU 2018244442A AU 2018244442 A1 AU2018244442 A1 AU 2018244442A1
Authority
AU
Australia
Prior art keywords
indirubin
solvent
dihydro
derivative
benzazepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2018244442A
Other languages
English (en)
Inventor
Paul Boucher
Bin Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytodigm Inc
Original Assignee
Cytodigm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytodigm Inc filed Critical Cytodigm Inc
Publication of AU2018244442A1 publication Critical patent/AU2018244442A1/en
Assigned to CYTODIGM, INC. reassignment CYTODIGM, INC. Request for Assignment Assignors: PHOSPHOREX, INC.
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018244442A 2017-03-29 2018-03-29 Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same Abandoned AU2018244442A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478317P 2017-03-29 2017-03-29
US62/478,317 2017-03-29
PCT/US2018/025075 WO2018183631A1 (en) 2017-03-29 2018-03-29 Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same

Publications (1)

Publication Number Publication Date
AU2018244442A1 true AU2018244442A1 (en) 2019-10-24

Family

ID=63676834

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018244442A Abandoned AU2018244442A1 (en) 2017-03-29 2018-03-29 Novel pharmaceutical formulations containing indirubin and derivatives thereof and methods of making and using the same

Country Status (7)

Country Link
US (3) US20200016087A1 (https=)
EP (1) EP3600259A4 (https=)
JP (2) JP2020515598A (https=)
CN (2) CN115969814A (https=)
AU (1) AU2018244442A1 (https=)
CA (1) CA3058407A1 (https=)
WO (1) WO2018183631A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101855423B1 (ko) * 2017-04-18 2018-05-09 주식회사 씨케이바이오텍 인디루빈 유도체를 유효성분으로 포함하는 약학 조성물
MX2021012548A (es) * 2019-04-17 2023-01-05 Azora Therapeutics Inc Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.
US12303490B2 (en) 2019-11-04 2025-05-20 Ck Regeon Inc. Compositions and methods for suppressing and/or treating neurodegenerative diseases and/or a clinical condition thereof
CN115175673A (zh) * 2020-02-26 2022-10-11 上海科技大学 双硫仑在抗冠状病毒中的应用
WO2022229985A1 (en) * 2021-04-29 2022-11-03 Jawaharlal Nehru Centre For Advanced Scientific Research Soluble analogues of 6bio thereof and implementation thereof
CN118317948A (zh) 2021-10-08 2024-07-09 阿佐拉治疗股份有限公司 芳烃受体激动剂的衍生物
CN114668744A (zh) * 2022-03-23 2022-06-28 成都大学 一种靛玉红固体脂质纳米粒及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1686988A1 (en) * 2003-10-28 2006-08-09 The Rockefeller University Indirubin-type compounds, compositions, and methods for their use
WO2012012616A1 (en) * 2010-07-21 2012-01-26 Patty-Fu Giles Photoactive vitamin nanoparticles for the treatment of chronic wounds
WO2012135813A1 (en) * 2011-03-31 2012-10-04 University Of Rochester Methods and compositions for mesenchymal stem cell proliferation
US9707186B2 (en) * 2012-02-21 2017-07-18 Amrita Vishwa Vidyapeetham Core-shell particle formulation for delivering multiple therapeutic agents
WO2013124867A1 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University Polymer - polymer or polymer - protein core - shell nano medicine loaded with multiple drug molecules
ES2685743T3 (es) * 2012-02-29 2018-10-11 Merck Patent Gmbh Procedimiento para la fabricación de nanopartículas cargadas con principio activo
EP2863897B1 (en) * 2012-06-21 2019-06-19 Phosphorex Inc. Nanoparticles of indirubin, derivatives thereof and methods of making and using same
WO2014152451A2 (en) * 2013-03-14 2014-09-25 University Of Rochester Compositions and methods for controlled localized delivery of bone forming therapeutic agents
CN103550206B (zh) * 2013-10-23 2015-11-25 重庆市中药研究院 一种白藜芦醇靛玉红组合药物、缓释微囊剂及其应用
EP2878312A1 (en) * 2013-12-02 2015-06-03 Albert-Ludwigs-Universität Freiburg Reversible PEGylation of nanocarriers
JP2017500343A (ja) * 2013-12-20 2017-01-05 フォスフォレックス,インコーポレーテッド インジルビン固体分散体組成物
WO2016197262A1 (en) * 2015-06-12 2016-12-15 Bayer Pharma Aktiengesellschaft Process for the preparation of porous microparticles
JP2018523702A (ja) * 2015-08-17 2018-08-23 フォスフォレックス,インコーポレイテッド 分解性ポリマーの極小ナノ粒子

Also Published As

Publication number Publication date
CN110709066A (zh) 2020-01-17
WO2018183631A1 (en) 2018-10-04
JP2020515598A (ja) 2020-05-28
CA3058407A1 (en) 2018-10-04
US20230100193A1 (en) 2023-03-30
US20200016087A1 (en) 2020-01-16
WO2018183631A8 (en) 2019-08-15
EP3600259A4 (en) 2020-11-25
US20200383931A1 (en) 2020-12-10
EP3600259A1 (en) 2020-02-05
JP2023040147A (ja) 2023-03-22
CN115969814A (zh) 2023-04-18

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: CYTODIGM, INC.

Free format text: FORMER APPLICANT(S): PHOSPHOREX, INC.

MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application