AU2018243796B8 - Injectable and biodegradable polymer formulations for controlled release of bioactive agents - Google Patents

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Publication number

AU2018243796B8

AU2018243796B8 AU2018243796A AU2018243796A AU2018243796B8 AU 2018243796 B8 AU2018243796 B8 AU 2018243796B8 AU 2018243796 A AU2018243796 A AU 2018243796A AU 2018243796 A AU2018243796 A AU 2018243796A AU 2018243796 B8 AU2018243796 B8 AU 2018243796B8

Authority

AU

Australia

Prior art keywords

injection

tmc

formulation

pla

receptor

Prior art date

2017-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 239000012867 bioactive agent Substances 0.000 title claims abstract description 78
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• 239000004621 biodegradable polymer Substances 0.000 title abstract description 11
• 238000013270 controlled release Methods 0.000 title description 9
• YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims abstract description 214
• 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 131
• 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 107
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• 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 16
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• URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 48
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• DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 9
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