AU2017383100B2 - Methods for enhancing vascular density - Google Patents

Methods for enhancing vascular density Download PDF

Info

Publication number
AU2017383100B2
AU2017383100B2 AU2017383100A AU2017383100A AU2017383100B2 AU 2017383100 B2 AU2017383100 B2 AU 2017383100B2 AU 2017383100 A AU2017383100 A AU 2017383100A AU 2017383100 A AU2017383100 A AU 2017383100A AU 2017383100 B2 AU2017383100 B2 AU 2017383100B2
Authority
AU
Australia
Prior art keywords
subject
sirt1
nad
mice
exercise
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017383100A
Other languages
English (en)
Other versions
AU2017383100A1 (en
Inventor
Abhirup Das
David Andrew Sinclair
Lindsay Edward WU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metro International Biotech LLC
Original Assignee
Metro International Biotech LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016905310A external-priority patent/AU2016905310A0/en
Application filed by Metro International Biotech LLC filed Critical Metro International Biotech LLC
Publication of AU2017383100A1 publication Critical patent/AU2017383100A1/en
Application granted granted Critical
Publication of AU2017383100B2 publication Critical patent/AU2017383100B2/en
Assigned to METRO INTERNATIONAL BIOTECH, LLC reassignment METRO INTERNATIONAL BIOTECH, LLC Request for Assignment Assignors: NEWSOUTH INNOVATIONS PTY LIMITED
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2017383100A 2016-12-21 2017-12-21 Methods for enhancing vascular density Active AU2017383100B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016905310A AU2016905310A0 (en) 2016-12-21 Methods for enhancing vascular density
AU2016905310 2016-12-21
PCT/AU2017/051435 WO2018112541A1 (en) 2016-12-21 2017-12-21 Methods for enhancing vascular density

Publications (2)

Publication Number Publication Date
AU2017383100A1 AU2017383100A1 (en) 2019-07-18
AU2017383100B2 true AU2017383100B2 (en) 2023-04-06

Family

ID=62624132

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017383100A Active AU2017383100B2 (en) 2016-12-21 2017-12-21 Methods for enhancing vascular density

Country Status (8)

Country Link
US (2) US20190328761A1 (cg-RX-API-DMAC7.html)
EP (1) EP3558312A4 (cg-RX-API-DMAC7.html)
JP (1) JP2020504722A (cg-RX-API-DMAC7.html)
KR (1) KR20190110547A (cg-RX-API-DMAC7.html)
CN (2) CN116509885A (cg-RX-API-DMAC7.html)
AU (1) AU2017383100B2 (cg-RX-API-DMAC7.html)
CA (1) CA3047437A1 (cg-RX-API-DMAC7.html)
WO (1) WO2018112541A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3331894B1 (en) 2015-08-05 2021-02-17 Metro International Biotech, LLC Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
CN109674808A (zh) * 2019-01-30 2019-04-26 四川大学 β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途
CN110638826A (zh) * 2019-10-09 2020-01-03 泓博元生命科技（深圳）有限公司 Nadh和/或nmn在制备肌肉增强或抑制肌肉量下降的药物或保健品中的应用
CN110734950A (zh) * 2019-11-14 2020-01-31 南方医科大学珠江医院 一种nmn治疗与改善cmva的相关性的体外实验法
CN110974781A (zh) * 2020-01-02 2020-04-10 崔立峰 一种用于皮肤创面修复的凝胶
IL296262A (en) * 2020-03-11 2022-11-01 Massachusetts Eye & Ear Infirmary Gene therapy for nmnat1-related retinal degeneration
EP4070799A1 (en) * 2021-04-08 2022-10-12 Nuvamid SA Compositions for the improvement of sport performance
WO2023159601A1 (en) * 2022-02-28 2023-08-31 Shenzhen University Use of agent deacetylating klf4 to promote transcriptional activity thereof, method for maintaining functions of pulmonary artery endothelial cells, and method for treating pulmonary arterial hypertension
CN115227712A (zh) * 2022-07-26 2022-10-25 上海市第五人民医院 NaHS在制备治疗骨质疏松药物中的应用
CN121152567A (zh) 2023-05-12 2025-12-16 明治控股股份有限公司 用于促进儿童的发育的组合物
AU2023457472A1 (en) * 2023-06-29 2025-03-13 Racehorse Incorporated Nutrient composition for animals
CN117771375A (zh) * 2024-01-31 2024-03-29 中山大学附属第三医院 SIRT1/PGC-1α通路激活剂的新用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002914A1 (en) * 2004-06-04 2006-01-05 Jeffrey Milbrandt Methods and compositions for treating neuropathies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1853590A1 (en) * 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US7855289B2 (en) * 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CN102985553B (zh) * 2010-04-15 2015-11-25 西特里斯药业公司 沉默调节蛋白活化剂和活化测定
US20140065099A1 (en) * 2011-02-15 2014-03-06 Ecole Polytechnique Federale De Lausanne (Epfl) Methods of Treating Mitochondrial Dysfunction
WO2013002879A1 (en) * 2011-06-29 2013-01-03 President And Fellows Of Harvard College Small molecule cd38 inhibitors and methods of using same
US9877981B2 (en) * 2012-10-09 2018-01-30 President And Fellows Of Harvard College NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
US20170087180A1 (en) * 2014-06-03 2017-03-30 Sulfagenix, Inc. Methods and compositions for treating nitric oxide deficiency disorders and related conditions
WO2016086088A2 (en) * 2014-11-25 2016-06-02 Northwestern University Wound healing through sirt1 overexpression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060002914A1 (en) * 2004-06-04 2006-01-05 Jeffrey Milbrandt Methods and compositions for treating neuropathies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. VINCIGUERRA, M. FULCO, A. LADURNER, V. SARTORELLI, N. ROSENTHAL: "SirT1 in muscle physiology and disease: lessons from mouse models", DISEASE MODELS & MECHANISMS, THE COMPANY OF BIOLOGISTS LTD., GB, vol. 3, no. 5-6, 1 May 2010 (2010-05-01), GB , pages 298 - 303, XP055757329, ISSN: 1754-8403, DOI: 10.1242/dmm.004655 *

Also Published As

Publication number Publication date
EP3558312A4 (en) 2021-01-13
KR20190110547A (ko) 2019-09-30
CN116509885A (zh) 2023-08-01
US20190328761A1 (en) 2019-10-31
CN110325190A (zh) 2019-10-11
AU2017383100A1 (en) 2019-07-18
EP3558312A1 (en) 2019-10-30
WO2018112541A1 (en) 2018-06-28
JP2020504722A (ja) 2020-02-13
US20230149437A1 (en) 2023-05-18
CA3047437A1 (en) 2018-06-28

Similar Documents

Publication Publication Date Title
US20230149437A1 (en) Methods for enhancing vascular density
Das et al. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
Yang et al. IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: role of epigenetic regulation
Huang et al. Downregulation of microRNA‐155 stimulates sevoflurane‐mediated cardioprotection against myocardial ischemia/reperfusion injury by binding to SIRT1 in mice
Li et al. Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction
Li et al. Overexpression of microRNA-99a attenuates cardiac hypertrophy
EP2976094B1 (en) Methods of treating metabolic disorders
Song et al. STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia
CN106062194A (zh) 用于调整肌腱愈合的材料和方法
JP6978774B2 (ja) 心不全の予防又は治療のための医薬組成物
Wang et al. Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability: Fgf13 knockout attenuates cardiac fibrosis
Yeh Cellular senescence and aging.
Pan et al. miR‐199a‐3p mitigates simulated microgravity‐induced cardiac remodeling by targeting MEF2C
Zhang et al. The role of NADPH oxidases in cardiovascular disease
Johnson et al. AAV9 gene therapy restores lifespan and treats pathological and behavioral abnormalities in a mouse model of CLN8-Batten disease
CN119770660B (zh) Papss1激动剂、内源性蛋白质硫酸化修饰上调剂在制备及筛选治疗缺血性疾病药物中的应用
CN115851902B (zh) Rp11-544d21.2的制药用途、在制备抗心衰药物方面的用途及药物与制备方法
Te Enabling skeletal muscle repair and functional recovery following denervation-induced injury using ultrasound mediated gene delivery (UMGD)
Mee-inta et al. Enhancement of meningeal lymphatic structure and function through running exercise mitigates amyloidosis in an Alzheimer’s disease mouse model
Tassinari Development of an innovative strategy to enhance the efficacy of gene therapy for CDKL5 deficiency disorder
Villa et al. Treatment with ROS detoxifying gold clusters alleviates the progressive functional decline in a mouse model of Friedreich’s Ataxia
TWI585204B (zh) 用以治療癌症之短干擾核糖核酸分子
Djalalvandi Antagonising microRNAs that target the mitochondria shaping protein Opa1 ameliorates denervation-induced muscle atrophy.
JP2025500063A (ja) ｍｉＲ－４９９－５ｐ活性化剤を含むデュシェンヌ型筋ジストロフィーの予防用または治療用の組成物
KR20250139695A (ko) RhoB, 또는 이의 발현 촉진제 또는 활성화제를 유효성분으로 포함하는 발기 부전 예방 또는 치료용 약학적 조성물

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: METRO INTERNATIONAL BIOTECH, LLC

Free format text: FORMER OWNER(S): NEWSOUTH INNOVATIONS PTY LIMITED