AU2017349462B2 - Cancer-killing cells - Google Patents

Cancer-killing cells Download PDF

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Publication number
AU2017349462B2
AU2017349462B2 AU2017349462A AU2017349462A AU2017349462B2 AU 2017349462 B2 AU2017349462 B2 AU 2017349462B2 AU 2017349462 A AU2017349462 A AU 2017349462A AU 2017349462 A AU2017349462 A AU 2017349462A AU 2017349462 B2 AU2017349462 B2 AU 2017349462B2
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cancer
cell
cells
granulocyte
haematopoietic
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AU2017349462A
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AU2017349462A1 (en
Inventor
Alex BLYTH
Nico BRUYNIKS
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Lift Biosciences Ltd
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Lift Biosciences Ltd
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Priority to AU2022200843A priority Critical patent/AU2022200843C1/en
Priority to AU2024278621A priority patent/AU2024278621A1/en
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    • AHUMAN NECESSITIES
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/365Lactones
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    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
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AU2017349462A 2016-10-26 2017-10-25 Cancer-killing cells Active AU2017349462B2 (en)

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AU2022200843A AU2022200843C1 (en) 2016-10-26 2022-02-09 Cancer-killing cells
AU2024278621A AU2024278621A1 (en) 2016-10-26 2024-12-19 Cancer-killing cells

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GB1618106.7 2016-10-26
GBGB1618106.7A GB201618106D0 (en) 2016-10-26 2016-10-26 Cancer-killing cells
PCT/GB2017/053222 WO2018078367A1 (en) 2016-10-26 2017-10-25 Cancer-killing cells

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AU2017349462A1 AU2017349462A1 (en) 2019-04-04
AU2017349462B2 true AU2017349462B2 (en) 2021-11-11

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AU2017349462A Active AU2017349462B2 (en) 2016-10-26 2017-10-25 Cancer-killing cells
AU2018356921A Active AU2018356921B2 (en) 2016-10-26 2018-04-24 Cancer-killing cells
AU2022200843A Active AU2022200843C1 (en) 2016-10-26 2022-02-09 Cancer-killing cells
AU2024278621A Pending AU2024278621A1 (en) 2016-10-26 2024-12-19 Cancer-killing cells
AU2025205633A Pending AU2025205633A1 (en) 2016-10-26 2025-07-21 Cancer-killing cells

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201618106D0 (en) * 2016-10-26 2016-12-07 Lift Biosciences Ltd Cancer-killing cells
CN115094112A (zh) * 2022-06-06 2022-09-23 同济大学 一种抗癌效率、癌症进展与预后的标志物及方法
JP2026508019A (ja) * 2023-03-10 2026-03-09 リフト バイオサイエンシズ リミテッド 治療用組成物
WO2026062399A1 (en) 2024-09-19 2026-03-26 Lift Biosciences Ltd Granulocytes and granulocyte precursors

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ241855A (en) 1991-03-07 1994-04-27 Gen Hospital Corp Use of therapeutic cells to obtain cellular response to infection, tumours or autoimmune-generated cells, cells with chimaeric receptors (with binding component and destruction signal), dna encoding the receptor, vectors and antibodies to receptor
CA2109729A1 (en) 1992-03-23 1993-09-30 James G. Bender In vitro-derived human neutrophil precursor cells
WO1993025710A1 (en) * 1992-06-08 1993-12-23 Gen-Probe Incorporated Preparation of nucleic acid from mononuclear cells
US5846529A (en) 1993-08-23 1998-12-08 Nexell Therapeutics, Inc. Infusion of neutrophil precursors for treatment of neutropenia
WO1995010291A1 (en) 1993-10-08 1995-04-20 Cellpro Ii Methods for collection and cryopreservation of human granulocytes
US5599705A (en) 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
US5733541A (en) 1995-04-21 1998-03-31 The Regent Of The University Of Michigan Hematopoietic cells: compositions and methods
AU2002225959A1 (en) 2000-11-09 2002-05-21 Mayo Foundation For Medical Education And Research Absolute lymphocyte recovery and cancer survival
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2002951082A0 (en) 2002-08-30 2002-09-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic cellular agents
EP1680080A4 (en) 2003-10-31 2007-10-31 3M Innovative Properties Co NEUTROPHILIC ACTIVATION THROUGH COMPOUNDS TO MODIFY THE IMMUNE RESPONSE
CN105168250B (zh) * 2004-10-25 2019-02-05 塞勒兰特治疗公司 增殖骨髓细胞群体的方法及其应用
US7811815B2 (en) 2004-11-15 2010-10-12 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic uses of allogeneic myeloid progenitor cells
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
US20080089875A1 (en) * 2006-10-13 2008-04-17 Zheng Cui Methods and compositions for the treatment of cancer
RU2548741C2 (ru) 2009-03-05 2015-04-20 Макрокьюэ, Лтд. Активированная лейкоцитарная композиция
US9199028B2 (en) 2010-01-15 2015-12-01 Memorial Sloan-Kettering Cancer Center Use of entrained neutrophils to treat metastatic and micrometastatic disease in at risk patients
US9862928B2 (en) 2010-12-03 2018-01-09 Regents Of The University Of Minnesota Generation of natural killer cells and lymphoid tissue inducer-like (LTi-like) NK-22 cells
CN103215340A (zh) 2012-01-19 2013-07-24 江苏粒福特生物科技有限公司 一种新颖的粒细胞制备及其抗癌活性检测方法
RU2603079C2 (ru) 2015-03-16 2016-11-20 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) Способ активации цитотоксических лимфоцитов человека
WO2017161001A1 (en) 2016-03-15 2017-09-21 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
GB201618106D0 (en) 2016-10-26 2016-12-07 Lift Biosciences Ltd Cancer-killing cells
WO2019147187A1 (en) 2018-01-26 2019-08-01 Agency For Science, Technology And Research Neutrophil subtypes
CN110755449A (zh) 2019-10-15 2020-02-07 南方科技大学 一种光调控嗜中性粒细胞在治疗癌症的药物中的应用
GB201918341D0 (en) 2019-12-12 2020-01-29 Lift Biosciences Ltd Cells for treating infections
GB201918313D0 (en) 2019-12-12 2020-01-29 Lift Biosciences Ltd Cells for treating cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TIMMINS, N.E., et al., "Clinical Scale Ex Vivo Manufacture of Neutrophils From Hematopoietic Progenitor Cells", 2009, Biotechnology and Bioengineering, Vol. 104, No. 4, pages 832-840 *

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