AU2017332789B2 - Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes - Google Patents

Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes Download PDF

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Publication number
AU2017332789B2
AU2017332789B2 AU2017332789A AU2017332789A AU2017332789B2 AU 2017332789 B2 AU2017332789 B2 AU 2017332789B2 AU 2017332789 A AU2017332789 A AU 2017332789A AU 2017332789 A AU2017332789 A AU 2017332789A AU 2017332789 B2 AU2017332789 B2 AU 2017332789B2
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rsv
leu
ile
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asn
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AU2017332789A
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AU2017332789A1 (en
Inventor
Ursula J. Buchholz
Peter L. Collins
Cyril LENOUEN
Steffen Mueller
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Codagenix Inc
US Department of Health and Human Services
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Usa As Represented By Secretary
Codagenix Inc
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Priority to AU2021218112A priority Critical patent/AU2021218112B2/en
Priority to AU2022256195A priority patent/AU2022256195B2/en
Priority to AU2024203948A priority patent/AU2024203948A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/00061—Methods of inactivation or attenuation
    • C12N2760/00062—Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2017332789A 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes Active AU2017332789B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2021218112A AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662399133P 2016-09-23 2016-09-23
US62/399,133 2016-09-23
US201662400476P 2016-09-27 2016-09-27
US62/400,476 2016-09-27
PCT/US2017/053047 WO2018057950A1 (en) 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021218112A Division AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Publications (2)

Publication Number Publication Date
AU2017332789A1 AU2017332789A1 (en) 2019-05-09
AU2017332789B2 true AU2017332789B2 (en) 2021-05-27

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Family Applications (4)

Application Number Title Priority Date Filing Date
AU2017332789A Active AU2017332789B2 (en) 2016-09-23 2017-09-22 Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes
AU2021218112A Active AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A Active AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A Pending AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2021218112A Active AU2021218112B2 (en) 2016-09-23 2021-08-19 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2022256195A Active AU2022256195B2 (en) 2016-09-23 2022-10-21 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes
AU2024203948A Pending AU2024203948A1 (en) 2016-09-23 2024-06-11 Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes

Country Status (5)

Country Link
US (4) US10808012B2 (enExample)
EP (1) EP3515930A1 (enExample)
JP (3) JP7198759B2 (enExample)
AU (4) AU2017332789B2 (enExample)
WO (1) WO2018057950A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4190895A1 (en) 2013-02-08 2023-06-07 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
US10808012B2 (en) 2016-09-23 2020-10-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Vaccine candidates for human respiratory syncytial virus (RSV) having attenuated phenotypes
RU2020124143A (ru) 2017-12-22 2022-01-24 Кодадженикс Инк. Рекомбинантный вирус с областью деоптимизированной пары кодонов и его применение для лечения рака
CA3091508A1 (en) 2018-03-08 2019-09-12 Codagenix Inc. Attenuated flaviviruses
AU2021271702A1 (en) 2020-05-13 2023-01-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services RSV vaccine bearing one or more P gene mutations
EP4181956A4 (en) * 2020-07-16 2024-08-07 Griffith University VACCINE AGAINST A LIVE ATTENUATED VIRUS
CN117693360A (zh) * 2021-04-08 2024-03-12 科达金尼克斯有限公司 引发针对呼吸道合胞病毒的免疫应答的方法
WO2025054424A1 (en) * 2023-09-06 2025-03-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human parainfluenza virus immunogenic molecules
WO2025128971A1 (en) * 2023-12-14 2025-06-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rsv vaccine bearing a polynucleotide which is de-optimised and de-attenuated

Citations (1)

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Publication number Priority date Publication date Assignee Title
US20150368622A1 (en) * 2013-02-08 2015-12-24 The United Of America, As Represented By Secretary, Department Of Health And Human Services Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization

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DE3224404A1 (de) 1982-06-30 1984-01-05 LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl Reibungskupplung sowie verfahren zu deren montage
WO1997012032A1 (en) 1995-09-27 1997-04-03 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Production of infectious respiratory syncytial virus from cloned nucleotide sequences
EP0912724B1 (en) 1996-07-15 2009-12-09 The Government of The United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
DE69842165D1 (de) 1997-05-23 2011-04-21 Us Of America As Represented By The Secretary Of The Dept Of Health And Human Services Herstellung attenuierter parainfluenza-virus impfstoffe aus klonierten nukleotidsequenzen
AU4065500A (en) 1999-04-13 2000-11-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
WO2002042326A1 (en) 2000-11-22 2002-05-30 Biota Scientific Management Pty Ltd A method of expression and agents identified thereby
WO2006085987A2 (en) 2004-07-09 2006-08-17 University Of Iowa Research Foundation Rna interference in respiratory epitheial cells
CA2587084C (en) 2004-10-08 2019-07-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Modulation of replicative fitness by using less frequently used synonym ous codons
KR101621100B1 (ko) 2007-03-30 2016-05-13 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 백신에 유용한 약독화 바이러스
MX2011004719A (es) 2008-11-05 2011-05-31 Merck Sharp & Dohme Virus sincitial respiratorio vivo atenuado.
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Non-Patent Citations (1)

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C. LE NOUEN ET AL, "Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, US, (2014-08-25), vol. 111, no. 36, pages 13169 - 13174 *

Also Published As

Publication number Publication date
AU2021218112A1 (en) 2021-09-09
AU2022256195A1 (en) 2023-02-02
JP7573001B2 (ja) 2024-10-24
AU2021218112B2 (en) 2022-07-21
US11390651B2 (en) 2022-07-19
EP3515930A1 (en) 2019-07-31
JP7198759B2 (ja) 2023-01-04
AU2017332789A1 (en) 2019-05-09
JP2025020142A (ja) 2025-02-12
AU2022256195B2 (en) 2024-03-14
US20240417431A1 (en) 2024-12-19
US20220340619A1 (en) 2022-10-27
JP2019534709A (ja) 2019-12-05
US20210188920A1 (en) 2021-06-24
AU2024203948A1 (en) 2024-07-04
WO2018057950A1 (en) 2018-03-29
US12054519B2 (en) 2024-08-06
US20190233476A1 (en) 2019-08-01
US10808012B2 (en) 2020-10-20
JP2022188047A (ja) 2022-12-20

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