AU2017324655B2 - New use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection - Google Patents
New use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection Download PDFInfo
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- AU2017324655B2 AU2017324655B2 AU2017324655A AU2017324655A AU2017324655B2 AU 2017324655 B2 AU2017324655 B2 AU 2017324655B2 AU 2017324655 A AU2017324655 A AU 2017324655A AU 2017324655 A AU2017324655 A AU 2017324655A AU 2017324655 B2 AU2017324655 B2 AU 2017324655B2
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- Prior art keywords
- triazolo
- pyrimidine derivative
- pyrimidin
- difluorophenyl
- propylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16188201.4 | 2016-09-09 | ||
| EP16188201.4A EP3292867B1 (en) | 2016-09-09 | 2016-09-09 | Triazolo(4,5-d)pyrimidine derivatives for use in the prevention and treatment of bacterial infection |
| PCT/EP2017/068811 WO2018046174A1 (en) | 2016-09-09 | 2017-07-25 | New use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection |
Publications (2)
| Publication Number | Publication Date |
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| AU2017324655A1 AU2017324655A1 (en) | 2019-03-07 |
| AU2017324655B2 true AU2017324655B2 (en) | 2021-04-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017324655A Active AU2017324655B2 (en) | 2016-09-09 | 2017-07-25 | New use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection |
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| Country | Link |
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| US (1) | US20190194213A1 (ja) |
| EP (2) | EP3292867B1 (ja) |
| JP (1) | JP7075667B2 (ja) |
| KR (1) | KR102401152B1 (ja) |
| CN (1) | CN109689061B (ja) |
| AU (1) | AU2017324655B2 (ja) |
| BR (1) | BR112019003661A2 (ja) |
| CA (1) | CA3035686C (ja) |
| DK (2) | DK3292867T3 (ja) |
| ES (2) | ES2731658T3 (ja) |
| WO (1) | WO2018046174A1 (ja) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3527571A1 (en) | 2018-02-14 | 2019-08-21 | Université de Liège | Pyrimidine derivatives for prevention and treatment of bacterial infection |
| JP2022529052A (ja) * | 2019-04-18 | 2022-06-16 | ユニベルシテ・ド・リエージュ | グラム陰性細菌の感染、汚染、及びファウリングを予防及び治療するための新規ピリミジン誘導体 |
| GB201910656D0 (en) * | 2019-07-25 | 2019-09-11 | Univ Liege | New use of triazolo(4,5-d)Pyrimidine deerivatives |
| JP2024510363A (ja) | 2021-02-26 | 2024-03-07 | ユニベルシテ・ド・リエージュ | 新規の抗菌かつ抗血栓性の医療機器 |
| CN117003756A (zh) * | 2022-05-04 | 2023-11-07 | 华东师范大学 | 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂 |
| EP4289435A1 (en) | 2022-06-07 | 2023-12-13 | Université de Liège | N-alkyl-2-substituted atp analogues for use as antibacterial agent |
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| WO2000034283A1 (en) * | 1998-12-04 | 2000-06-15 | Astrazeneca Ab | Novel triazolo(4,5-d)pyrimidine compounds |
| US6251910B1 (en) * | 1997-07-22 | 2001-06-26 | Astrazeneca Uk Limited | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists |
| US7265124B2 (en) * | 2000-06-02 | 2007-09-04 | Astrazeneca Ab | Cristalline and amorphous form of a triazolo (4,5-D) pyridimine compound |
| WO2013092900A1 (en) * | 2011-12-23 | 2013-06-27 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
| WO2014000719A1 (en) * | 2012-06-29 | 2014-01-03 | Zentiva, K.S. | Novel pharmaceutical solid forms of (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4difluorophenyl)cyclopropylamino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-diol |
| US8802850B2 (en) * | 2009-07-27 | 2014-08-12 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of P2Y12 receptor |
| US8883802B2 (en) * | 2009-12-03 | 2014-11-11 | Astrazeneca Ab | Co-crystals of a triazolo [4,5-D] pyrimide platelet aggregation inhibitor |
| WO2015014089A1 (zh) * | 2013-08-02 | 2015-02-05 | 上海京新生物医药有限公司 | 替格瑞洛的一水合物及其制备方法与在制药中的应用 |
| US9101642B2 (en) * | 2011-06-01 | 2015-08-11 | Astrazeneca Ab | Ticagrelor co-crystal |
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| WO2016116942A1 (en) * | 2015-01-20 | 2016-07-28 | Anlon Chemical Research Organization | Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
-
2016
- 2016-09-09 ES ES16188201T patent/ES2731658T3/es active Active
- 2016-09-09 DK DK16188201.4T patent/DK3292867T3/da active
- 2016-09-09 EP EP16188201.4A patent/EP3292867B1/en not_active Not-in-force
-
2017
- 2017-07-25 JP JP2019513341A patent/JP7075667B2/ja active Active
- 2017-07-25 WO PCT/EP2017/068811 patent/WO2018046174A1/en unknown
- 2017-07-25 AU AU2017324655A patent/AU2017324655B2/en active Active
- 2017-07-25 BR BR112019003661-0A patent/BR112019003661A2/pt active Search and Examination
- 2017-07-25 ES ES17743050T patent/ES2841742T3/es active Active
- 2017-07-25 CN CN201780054753.2A patent/CN109689061B/zh active Active
- 2017-07-25 KR KR1020197008453A patent/KR102401152B1/ko active IP Right Grant
- 2017-07-25 EP EP17743050.1A patent/EP3509598B1/en active Active
- 2017-07-25 DK DK17743050.1T patent/DK3509598T3/da active
- 2017-07-25 US US16/331,920 patent/US20190194213A1/en not_active Abandoned
- 2017-07-25 CA CA3035686A patent/CA3035686C/en active Active
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| US6251910B1 (en) * | 1997-07-22 | 2001-06-26 | Astrazeneca Uk Limited | 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists |
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| US7265124B2 (en) * | 2000-06-02 | 2007-09-04 | Astrazeneca Ab | Cristalline and amorphous form of a triazolo (4,5-D) pyridimine compound |
| US8802850B2 (en) * | 2009-07-27 | 2014-08-12 | Auspex Pharmaceuticals, Inc. | Cyclopropyl modulators of P2Y12 receptor |
| US8883802B2 (en) * | 2009-12-03 | 2014-11-11 | Astrazeneca Ab | Co-crystals of a triazolo [4,5-D] pyrimide platelet aggregation inhibitor |
| US9101642B2 (en) * | 2011-06-01 | 2015-08-11 | Astrazeneca Ab | Ticagrelor co-crystal |
| WO2013092900A1 (en) * | 2011-12-23 | 2013-06-27 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
| US9233966B2 (en) * | 2012-04-05 | 2016-01-12 | Dr. Reddy's Laboratories Limited | Preparation of ticagrelor |
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| WO2015014089A1 (zh) * | 2013-08-02 | 2015-02-05 | 上海京新生物医药有限公司 | 替格瑞洛的一水合物及其制备方法与在制药中的应用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| NZ751185A (en) | 2023-10-27 |
| JP7075667B2 (ja) | 2022-05-26 |
| KR20190045237A (ko) | 2019-05-02 |
| ES2731658T3 (es) | 2019-11-18 |
| EP3292867B1 (en) | 2019-05-15 |
| CN109689061A (zh) | 2019-04-26 |
| US20190194213A1 (en) | 2019-06-27 |
| KR102401152B1 (ko) | 2022-05-24 |
| BR112019003661A2 (pt) | 2019-05-21 |
| AU2017324655A1 (en) | 2019-03-07 |
| DK3509598T3 (da) | 2020-12-21 |
| EP3509598B1 (en) | 2020-10-07 |
| CA3035686C (en) | 2023-07-25 |
| ES2841742T3 (es) | 2021-07-09 |
| CA3035686A1 (en) | 2018-03-15 |
| CN109689061B (zh) | 2023-03-31 |
| DK3292867T3 (da) | 2019-07-22 |
| EP3509598A1 (en) | 2019-07-17 |
| EP3292867A1 (en) | 2018-03-14 |
| WO2018046174A1 (en) | 2018-03-15 |
| JP2019529398A (ja) | 2019-10-17 |
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