AU2017306158B2 - Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof - Google Patents

Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof Download PDF

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Publication number
AU2017306158B2
AU2017306158B2 AU2017306158A AU2017306158A AU2017306158B2 AU 2017306158 B2 AU2017306158 B2 AU 2017306158B2 AU 2017306158 A AU2017306158 A AU 2017306158A AU 2017306158 A AU2017306158 A AU 2017306158A AU 2017306158 B2 AU2017306158 B2 AU 2017306158B2
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compound
group
nmdar
phenyl
hydrogen
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AU2017306158A1 (en
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Amin M. Khan
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Aptinyx Inc
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Aptinyx Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2017306158A 2016-08-01 2017-08-01 Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof Ceased AU2017306158B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369534P 2016-08-01 2016-08-01
US62/369,534 2016-08-01
PCT/US2017/044861 WO2018026792A1 (en) 2016-08-01 2017-08-01 Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof

Publications (2)

Publication Number Publication Date
AU2017306158A1 AU2017306158A1 (en) 2019-01-31
AU2017306158B2 true AU2017306158B2 (en) 2021-10-14

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AU2017306158A Ceased AU2017306158B2 (en) 2016-08-01 2017-08-01 Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof

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US (2) US11028095B2 (enExample)
EP (1) EP3490994B8 (enExample)
JP (1) JP2019527235A (enExample)
KR (1) KR102462288B1 (enExample)
CN (1) CN109661398B (enExample)
AU (1) AU2017306158B2 (enExample)
BR (1) BR112019001926A2 (enExample)
CL (1) CL2019000249A1 (enExample)
CO (1) CO2019000944A2 (enExample)
EA (1) EA201990425A1 (enExample)
ES (1) ES2979128T3 (enExample)
IL (1) IL264496B (enExample)
MX (1) MX383292B (enExample)
PE (1) PE20190502A1 (enExample)
SG (1) SG11201900546UA (enExample)
WO (1) WO2018026792A1 (enExample)

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CN109661398B (zh) 2016-08-01 2022-07-05 阿普廷伊克斯股份有限公司 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途
CA3031539C (en) 2016-08-01 2023-11-28 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
AU2017306152A1 (en) 2016-08-01 2019-01-31 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
MX388786B (es) 2016-08-01 2025-03-20 Aptinyx Inc Moduladores nmda espiro-lactam y métodos de uso de los mismos.
CN109906218B (zh) 2016-08-01 2023-01-17 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
US10416340B2 (en) 2017-05-27 2019-09-17 ADANI Systems, Inc. Autonomous container-transportable system for vehicle scanning
CN112204031B (zh) 2018-01-31 2024-05-24 元羿生物科技(香港)有限公司 螺-内酰胺nmda受体调节剂及其用途
WO2019152681A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

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US20200181159A1 (en) 2020-06-11
EP3490994A1 (en) 2019-06-05
CN109661398B (zh) 2022-07-05
EP3490994B8 (en) 2024-03-13
WO2018026792A1 (en) 2018-02-08
IL264496A (enExample) 2019-03-31
SG11201900546UA (en) 2019-02-27
CO2019000944A2 (es) 2019-02-08
CN109661398A (zh) 2019-04-19
MX2019001322A (es) 2019-09-11
US20220098211A1 (en) 2022-03-31
CL2019000249A1 (es) 2019-06-21
MX383292B (es) 2025-03-13
BR112019001926A2 (pt) 2019-08-06
PE20190502A1 (es) 2019-04-10
IL264496B (en) 2022-09-01
EA201990425A1 (ru) 2019-08-30
KR102462288B1 (ko) 2022-11-01
CA3031562A1 (en) 2018-02-08
AU2017306158A1 (en) 2019-01-31
EP3490994C0 (en) 2024-02-07
ES2979128T3 (es) 2024-09-24
US11028095B2 (en) 2021-06-08
JP2019527235A (ja) 2019-09-26
KR20190037276A (ko) 2019-04-05
EP3490994B1 (en) 2024-02-07

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