AU2017285813B2 - Method for producing diphenylmethane derivative - Google Patents

Method for producing diphenylmethane derivative Download PDF

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Publication number
AU2017285813B2
AU2017285813B2 AU2017285813A AU2017285813A AU2017285813B2 AU 2017285813 B2 AU2017285813 B2 AU 2017285813B2 AU 2017285813 A AU2017285813 A AU 2017285813A AU 2017285813 A AU2017285813 A AU 2017285813A AU 2017285813 B2 AU2017285813 B2 AU 2017285813B2
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Australia
Prior art keywords
formula
compound
following formula
reaction
alkyl
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AU2017285813A
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AU2017285813A1 (en
Inventor
Soongyu Choi
Min Ju Kim
Younggyu Kong
Eun-Jung Park
Se-Hwan Park
So Ok PARK
Hee Jeong Seo
Kwang-Seop Song
Hee-Kyoon Yoon
Ji-Sung Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daewoong Pharmaceutical Co Ltd
GC Biopharma Corp
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Green Cross Corp Korea
Daewoong Pharmaceutical Co Ltd
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Application filed by Green Cross Corp Korea, Daewoong Pharmaceutical Co Ltd filed Critical Green Cross Corp Korea
Publication of AU2017285813A1 publication Critical patent/AU2017285813A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B51/00—Introduction of protecting groups or activating groups, not provided for in the preceding groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017285813A 2016-06-17 2017-06-15 Method for producing diphenylmethane derivative Active AU2017285813B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2016-0075910 2016-06-17
KR20160075910 2016-06-17
PCT/KR2017/006271 WO2017217792A1 (ko) 2016-06-17 2017-06-15 다이페닐메탄 유도체의 제조방법

Publications (2)

Publication Number Publication Date
AU2017285813A1 AU2017285813A1 (en) 2019-01-17
AU2017285813B2 true AU2017285813B2 (en) 2020-02-06

Family

ID=60664449

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Application Number Title Priority Date Filing Date
AU2017285813A Active AU2017285813B2 (en) 2016-06-17 2017-06-15 Method for producing diphenylmethane derivative

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US (2) US10640496B2 (enExample)
EP (2) EP3663292B1 (enExample)
JP (4) JP6763978B2 (enExample)
KR (2) KR102233229B1 (enExample)
CN (2) CN113651803B (enExample)
AU (1) AU2017285813B2 (enExample)
CA (2) CA3026756C (enExample)
CL (1) CL2018003645A1 (enExample)
CO (1) CO2018014018A2 (enExample)
DK (2) DK3663292T3 (enExample)
DO (1) DOP2018000287A (enExample)
EC (1) ECSP19000185A (enExample)
ES (2) ES2891825T3 (enExample)
HR (1) HRP20211670T8 (enExample)
HU (1) HUE056428T2 (enExample)
MA (2) MA50774B1 (enExample)
MX (2) MX392177B (enExample)
MY (1) MY203941A (enExample)
NZ (1) NZ749398A (enExample)
PE (2) PE20190467A1 (enExample)
PH (1) PH12018550206A1 (enExample)
PL (2) PL3473621T3 (enExample)
PT (2) PT3473621T (enExample)
RS (1) RS62550B1 (enExample)
SA (2) SA521422474B1 (enExample)
SG (2) SG11201811154QA (enExample)
SI (1) SI3663292T1 (enExample)
TN (1) TN2018000437A1 (enExample)
WO (1) WO2017217792A1 (enExample)

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DE102011054773A1 (de) 2011-10-25 2013-04-25 Vb Autobatterie Gmbh & Co. Kgaa Anschlusspol für einen Akkumulator, Akkumulatorgehäuse und Maschine zur Herstellung eines Anschlusspols
PE20211206A1 (es) * 2018-08-13 2021-07-05 Dae Woong Pharma Preparacion de intermedio util para la sintesis de inhibidor de sglt
CN112341416A (zh) * 2019-08-09 2021-02-09 天津津艺医药科技发展有限责任公司 一种制备苯并含氧脂杂环衍生物的方法
WO2021172955A1 (ko) * 2020-02-27 2021-09-02 주식회사 대웅제약 Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법
US12448360B2 (en) * 2020-09-10 2025-10-21 Daewoong Pharmaceutical Co., Ltd. Synthesis method for preparing SGLT inhibitor intermediate
CN112094253B (zh) * 2020-09-10 2023-01-10 株式会社大熊制药 用于制备sglt抑制剂中间体的合成方法
CN113200860B (zh) * 2021-04-29 2024-07-30 爱斯特（成都）生物制药股份有限公司 一种sglt2抑制剂中间体的制备方法
KR20230046784A (ko) * 2021-09-30 2023-04-06 주식회사 대웅제약 이나보글리플로진을 포함하는 약학 조성물
CN113801010A (zh) * 2021-11-18 2021-12-17 山东诚创蓝海医药科技有限公司 一种5-溴-2-氯苯甲酸的制备方法
CN113912487B (zh) * 2021-11-23 2024-05-28 山东研峰新材料科技有限公司 一种2,5-双卤代苯甲酸的合成方法
KR20230110001A (ko) * 2022-01-14 2023-07-21 주식회사 대웅제약 Ssglt 저해제의 합성에 유용한 중간체의 제조 방법
KR20240044190A (ko) 2022-09-28 2024-04-04 주식회사 대웅제약 이나보글리플로진의 신규한 결정형 및 이의 제조방법
KR20240044194A (ko) 2022-09-28 2024-04-04 주식회사 대웅제약 이나보글리플로진의 신규한 공결정
CN119968202A (zh) 2022-09-29 2025-05-09 株式会社大熊制药 用于预防或治疗心血管衰老疾病的包含依那格列净的药物组合物
KR20240047952A (ko) 2022-10-05 2024-04-12 주식회사 대웅제약 이나보글리플로진을 포함하는 신장애 및/또는 당뇨병 예방 또는 치료용 약학 조성물
EP4631498A1 (en) 2022-12-21 2025-10-15 Daewoong Therapeutics Inc. Eye drop-type pharmaceutical composition containing envogliflozin
KR20240107660A (ko) 2022-12-30 2024-07-09 주식회사 대웅제약 이나보글리플로진 및 메트포르민을 포함하는 약학 조성물
KR102853437B1 (ko) * 2024-11-13 2025-09-04 대웅바이오(주) 연속반응 공정을 이용한 이나보글리플로진 합성방법
KR102837948B1 (ko) * 2024-11-13 2025-07-25 대웅바이오(주) 분배 투입법을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법
KR102837941B1 (ko) * 2024-11-13 2025-07-25 대웅바이오(주) Inline quenching 공정을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법

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PE20190467A1 (es) 2019-04-04
KR20170142904A (ko) 2017-12-28
CN113651803A (zh) 2021-11-16
MX2021008988A (es) 2022-05-05
US20190382390A1 (en) 2019-12-19
SG10201911782RA (en) 2020-02-27
EP3663292B1 (en) 2021-09-01
US10889574B2 (en) 2021-01-12
PT3473621T (pt) 2021-10-04
ES2898336T3 (es) 2022-03-07
SA518400666B1 (ar) 2021-11-30
JP2021152054A (ja) 2021-09-30
JP6763978B2 (ja) 2020-09-30
CN113651803B (zh) 2022-10-28
EP3473621B1 (en) 2021-08-04
PT3663292T (pt) 2021-11-08
HUE056428T2 (hu) 2022-02-28
DK3473621T3 (da) 2021-09-06
US20190169174A1 (en) 2019-06-06
CO2018014018A2 (es) 2019-03-08
RU2021129636A (ru) 2021-11-22
AU2017285813A1 (en) 2019-01-17
HRP20211670T8 (hr) 2022-03-18
EP3473621A4 (en) 2020-03-11
NZ749398A (en) 2020-01-31
KR20210036892A (ko) 2021-04-05
WO2017217792A1 (ko) 2017-12-21
PL3473621T3 (pl) 2022-01-10
PH12018550206A1 (en) 2019-09-30
MX2018015647A (es) 2019-04-11
ES2891825T3 (es) 2022-01-31
MA44545B2 (fr) 2020-11-30
JP7669206B2 (ja) 2025-04-28
EP3663292A1 (en) 2020-06-10
JP7773506B2 (ja) 2025-11-19
MY203941A (en) 2024-07-25
PE20240590A1 (es) 2024-03-21
CN109311861B (zh) 2021-08-24
JP2020117528A (ja) 2020-08-06
JP2019521985A (ja) 2019-08-08
CA3081033C (en) 2022-04-12
SG11201811154QA (en) 2019-01-30
BR112018076243A2 (pt) 2019-03-26
MA44545B1 (fr) 2020-05-29
TN2018000437A1 (en) 2020-06-15
MA44545A1 (fr) 2019-10-31
ECSP19000185A (es) 2019-01-31
CA3026756C (en) 2021-03-02
KR102379584B1 (ko) 2022-03-29
DK3663292T3 (da) 2021-10-25
CN109311861A (zh) 2019-02-05
DOP2018000287A (es) 2019-03-31
EP3473621A1 (en) 2019-04-24
MX392177B (es) 2025-03-19
RU2019101056A (ru) 2020-07-17
CA3026756A1 (en) 2017-12-21
JP7352509B2 (ja) 2023-09-28
SA521422474B1 (ar) 2023-11-02
HRP20211670T1 (hr) 2022-02-18
CL2018003645A1 (es) 2019-03-22
RS62550B1 (sr) 2021-12-31
PL3663292T3 (pl) 2022-01-17
RU2019101056A3 (enExample) 2020-07-17
MA50774A1 (fr) 2021-03-31
SI3663292T1 (sl) 2022-01-31
MX385640B (es) 2025-03-18
MA50774B1 (fr) 2022-02-28
KR102233229B1 (ko) 2021-03-29
CA3081033A1 (en) 2017-12-21
JP2023145481A (ja) 2023-10-11
US10640496B2 (en) 2020-05-05

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Name of requester: DAEWOONG PHARMACEUTICAL CO., LTD.